Neoplasms of the skin and subcutaneous tissues in dogs and cats

Bostock, D. E.

doi:10.1016/0007-1935(86)90002-3

Cited by 187 publications

(190 citation statements)

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“…Skin tumors corresponded to 36.1% (n=968). Hair follicle neoplasms represented 3.1% (n=82) of all neoplasms (n=2678) and 8.5% of all skin neoplasms, corroborating with the results obtained by Bostock (1986), Walder and Gross (1992), and Goorman and Dobson (1995). Trichoblastoma was the most common neoplasia, affecting 32 animals, followed by benign trichoepithelioma (n=30), benign pilomatricoma (n=7), malignant trichoepithelioma (n=6), infundibular keratinizing acanthoma (n=5), and tricholemmoma (n=2).…”

Section: Resultssupporting

confidence: 87%

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Association of nucleolar organizing regions and Ki-67 expression with recurrence rate of hair follicle tumor in dogs

Souza

Ocarino²,

Tavares³

et al. 2008

Arq. Bras. Med. Vet. Zootec.

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Mitotic index, nuclear diameter, number of nucleolar organizing regions, and Ki-67 expression, in hair follicle tumors of 82 dogs were evaluated. Tissue specimens were used to prepare sections for histological staining for number of nucleolar organizing region and immunohistochemical staining for Ki-67. Tumors were classified as trichoblastoma (n=32), benign trichoepithelioma (n=30), pilomatricoma (n=7), malignant trichoepithelioma (n=6), infundibular keratinizing acanthoma (n=5), and tricholemmoma (n=2). Head, dorsum, and limbs were the most affected sites. Malignant trichoepithelioma presented significantly higher mitotic index, number of nucleolar organizing regions and Ki-67 expression. Regarding benign neoplasms, trichoblastoma presented significantly higher mitotic index and number of nucleolar organizing regions. Ki-67 expression did not differ among hair follicle benign neoplasms. Recurrence was only observed in two cases, with one benign trichoepithelioma and one malignant trichoepithelioma. In the two cases, nodules have not been removed with clean surgical margin. It was concluded that in benign neoplasms of hair follicles, the number of nucleolar organizing regions and Ki-67 expression were significantly smaller than in malignant neoplasm. Clean surgical margins are suggested to be more responsible to tumor recurrences than the number of nucleolar organizing regions, expression of Ki-67, and the mitotic index.Keywords: dog, neoplasm, AgNOR, hair follicle, Ki-67 RESUMO O objetivo deste trabalho foi avaliar o índice mitótico, o diâmetro nuclear, o número de regiões organizadoras de nucléolos e a expressão do Ki-67 em 82 tumores de folículo piloso de cães, entre 2000 e 2006. Os tumores foram classificados como tricoblastoma (n=32), tricoepitelioma benigno (n=30), tricoepitelioma maligno (n=6), pilomatricoma (n=7), acantoma infundibular ceratinizante (n=5) e tricolemoma (n=2). A cabeça, o dorso e os membros foram os locais mais frequentemente acometidos. O tricoepitelioma maligno apresentou índice mitótico, número de regiões organizadoras de nucléolos e expressão do

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Section: Resultssupporting

confidence: 87%

“…Skin neoplasms and hair follicle tumors represent, respectively, about 30% and 5% from the total of neoplasms diagnosed in dogs (Bostock, 1986;Walder and Gross, 1992;Goorman and Dobson, 1995).…”

Section: Introductionmentioning

confidence: 99%

Association of nucleolar organizing regions and Ki-67 expression with recurrence rate of hair follicle tumor in dogs

Souza

Ocarino²,

Tavares³

et al. 2008

Arq. Bras. Med. Vet. Zootec.

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“…In this study 50 spontaneously arising, subcutaneous canine mast cell tumours were graded and the histological grade compared with the mean AgNOR count. For well differentiated neoplasms the mean count was 1.4 per cell compared with 6 Cutaneous mast cell tumours are the most common histologically confirmed skin neoplasms of dogs in many parts of the world (Bostock, 1986) and are usually amenable to surgical ablation when first presented. It has been shown that, for animals with no clinical evidence of residual tumour immediately following removal, behaviour is closely related to histological grade.…”

mentioning

confidence: 99%

“…Cutaneous mast cell tumours are the most common histologically confirmed skin neoplasms of dogs in many parts of the world (Bostock, 1986) and are usually amenable to surgical ablation when first presented. It has been shown that, for animals with no clinical evidence of residual tumour immediately following removal, behaviour is closely related to histological grade.…”

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confidence: 99%

Nucleolar organiser regions as indicators of post-surgical prognosis in canine spontaneous mast cell tumours

Bostock

Crocker²,

Harris³

et al. 1989

Br J Cancer

117

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Summary The average number of nucleolar organiser regions per cell has previously been shown to correlate well with histological grading techniques for a variety of neoplasms in man, and may thus be of value as an aid to post-surgical prognosis. In this study 50 spontaneously arising, subcutaneous canine mast cell tumours were graded and the histological grade compared with the mean AgNOR count. For well differentiated neoplasms the mean count was 1.4 per cell compared with 6 Cutaneous mast cell tumours are the most common histologically confirmed skin neoplasms of dogs in many parts of the world (Bostock, 1986) and are usually amenable to surgical ablation when first presented. It has been shown that, for animals with no clinical evidence of residual tumour immediately following removal, behaviour is closely related to histological grade. Thus, well differentiated tumours carry a favourable prognosis and poorly differentiated lesions a very guarded prognosis (Bostock, 1973;Patnaik et al., 1984). Many tumours, however, fall into an intermediate category in which the prognosis is more difficult to predict, with estimates of tumour related deaths varying between 20 and 50% (Bostock, 1986). Furthermore, the grading of mast cell tumours, particularly those of intermediate differentiation, is somewhat subjective, and there is marked discrepancy in the proportions of the various grades between series from different authors (Table I).Nucleolar organiser regions are present in the nucleus of all cells, where they act as the sites for transcription of rRNA. They can be visualised readily in either impression smears or formalin fixed, routinely processed paraffin sections because of their close association with proteins containing a large number of disulphide bonds, which bind to silver ions . They are, therefore, usually referred to as AgNORs when stained in this way.Crocker and his colleagues have shown that the average number of AgNORs per nucleus correlates well with histological grading methods for a variety of human neoplasms, including lymphomas (Crocker & Nar, 1987), mammary tumours and melanomas (Crocker & Skilbeck, 1987) while others (Derenzini et al., 1988) have similarly demonstrated an increased number in intestinal adenocarcinomas compared with hyperplastic polyps.In view of these correlations we considered that the number of AgNORs might be of value as a prospective indicator of prognosis in canine mast cell tumours, particularly in view of their ease of demonstration and objectivity of measurement.In dogs, most mast cell tumours which are destined to kill their host do so within 6 months of initial excision as a result either of inoperable local recurrence in the scar, or lymphatic metastasis (Bostock, 1973) which follow-up studies in excess of 5 years are normally required. Materials and methodsSpontaneously arising subcutaneous mast cell tumours were excised by veterinary surgeons in general practice, fixed in formal saline and submitted for histological examination. Data supplied at the time of submis...

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“…Mast cell tumors (MCTs) are highly invasive and metastatic and are the most frequent round cell tumors in dogs, comprising 16-21% of all cutaneous tumors diagnosed (Brodey, 1970;Bostock, 1986;Rothwell et al, 1987;Misdorp, 2004). It is unclear whether multiple MCTs represent metastatic spread or new neoplasms (Kiupel et al, 2005;Mullins et al, 2006;Murphy et al, 2006;Preziosi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Mackowiak

Gentile

Chaible

et al. 2012

The Veterinary Journal

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Neoplasms of the skin and subcutaneous tissues in dogs and cats

Cited by 187 publications

References 16 publications

Association of nucleolar organizing regions and Ki-67 expression with recurrence rate of hair follicle tumor in dogs

Association of nucleolar organizing regions and Ki-67 expression with recurrence rate of hair follicle tumor in dogs

Nucleolar organiser regions as indicators of post-surgical prognosis in canine spontaneous mast cell tumours

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

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