Neoplasms of the lungs, airways, and pleura

Hansell, David M.; Lynch, David A.; McAdams, H. Page; Bankier, Alexander A.

doi:10.1016/b978-0-7234-3496-2.00018-x

Cited by 13 publications

(11 citation statements)

References 755 publications

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“…As mentioned earlier, secondary malignancies in the tracheobronchial tree may occur as a result of hematogenous spread or direct invasion by a malignancy of the lung, larynx, esophagus, thyroid gland, or mediastinum (Fig 7), with direct invasion being far more common (20). In most cases, the extramural source of an airway tumor is apparent at CT. Hematogenous metastases usually originate from renal cell carcinoma (Fig 8), breast cancer, colon cancer, hepatocellular carcinoma, or melanoma (20).…”

Section: Secondary Malignant Tumorsmentioning

confidence: 94%

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Tumors in the Tracheobronchial Tree: CT and FDG PET Features

Park

Goo²,

Lee³

et al. 2009

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A variety of tumors, including primary malignant tumors, secondary malignant tumors, and benign tumors, can occur in the tracheobronchial tree. Primary malignant tumors commonly originate from the surface epithelium or the salivary glands, whereas most benign tumors arise from the mesenchymal tissue. At computed tomography (CT), primary malignant tumors manifest as a polypoid lesion, a focal sessile lesion, eccentric narrowing of the airway lumen, or circumferential wall thickening. At fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET), most squamous cell carcinomas show high uptake, whereas adenoid cystic carcinoma and mucoepidermoid carcinoma show variable uptake depending on the grade of differentiation. High-grade malignancies tend to show high and homogeneous uptake. Carcinoid tumors commonly show intense enhancement at contrast material-enhanced CT, which can be helpful in making the diagnosis, and usually have lower uptake at FDG PET than would be expected for a malignant tumor. Secondary malignant tumors occur as a result of either hematogenous metastasis or direct invasion by a malignancy from an adjacent structure. Their CT manifestations are similar to those of primary malignant tumors, with uptake at FDG PET depending primarily on the metabolic activity and degree of differentiation of the primary tumor. Among the benign tumors, hamartoma and lipoma can show characteristic CT findings such as "popcorn" calcification or internal fat. However, CT findings in most benign tumors are nonspecific. At FDG PET, benign tumors usually show little or no uptake and can be differentiated from malignant tumors. Knowledge of the characteristic CT and FDG PET findings of tracheobronchial tumors can aid in diagnosis and treatment planning.

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Section: Secondary Malignant Tumorsmentioning

confidence: 94%

“…Carcinoma.-SCC is the most common primary tracheobronchial malignancy and develops mainly in the 6th and 7th decades of life (20). This tumor is strongly associated with habitual cigarette smoking, affecting men two to four times more frequently than women (1).…”

Section: Squamous Cellmentioning

confidence: 99%

Tumors in the Tracheobronchial Tree: CT and FDG PET Features

Park

Goo²,

Lee³

et al. 2009

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“…O fator de risco mais importante associado ao câncer pulmonar é o tabagismo (8). Em nossa casuística, 44% (35/80) dos pacientes eram tabagistas.…”

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“…Em nossa casuística, 44% (35/80) dos pacientes eram tabagistas. Outros fatores incluem: exposição ao amianto, à radiação, a fatores ambientais e alimentares; infecção pelo vírus da imunodeficiência adquirida (HIV); fatores genéticos e fibrose pulmonar (8). Infecções que mimetizam o câncer são incomuns (7,20) Os métodos invasivos utilizados para o diagnóstico na literatura e em nossa casuística foram de 95% e 36%, respectivamente, sobretudo nos pacientes com suspeita de câncer pulmonar.…”

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Infecções Que Mimetizam Câncer: Avaliação Retrospectiva E Prospectiva De Micoses E Actinomicetoses

Bello¹,

Severo²,

Hochhegger³

et al. 2014

Rev Patol Trop

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e 5. RESUMOAs infecções que mimetizam neoplasia são incomuns. Por meio de um estudo retrospectivo, reunimos todos os casos de histoplasmose, criptococose por Cryptococcus gattii, actinomicose e nocardiose que mimetizaram neoplasia. A casuística foi constituída por 80 casos extraídos de uma população de 1.365 no período de 1981 a 2012. Revisamos criticamente os casos relatados na literatura (n=67). As manifestações clínico-radiológicas das lesões pulmonares nas doenças infecciosas (especialmente granulomatosas) e neoplasias não permitem realizar, com segurança, o diagnóstico diferencial. DESCRITORES: Infecções; neoplasia; micoses; actinomicoses. ABSTRACT Infection mimicking cancer: retrospective and prospective evaluation of mycosis and actinomycetousInfections that simulate neoplasia are uncommon. In a retrospective study we included all cases of histoplasmosis, cryptococcosis due to Cryptococcus gattii, actinomycosis and nocardiosis mimicking malignancy. The sample consisted of 80 cases extracted from a population of 1,365 during the period 1981-2012. We review critically the cases reported at literature (n=67). Clinical

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“…In case 1, the patient underwent the growth rate test, excluding neoplastic disease. This was based on the observation that benign lesions usually have doubling times of fewer than 30 days or greater than 450 days, and malignant lesions have doubling times between these values 16 . Nocardia spp.…”

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confidence: 99%