Neoplasms of Bone and Fibro-Osseous Lesions of the Craniofacial Skeleton

Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach

“…However, no apparent difference in clinical behavior has been documented. 13 Although classically associated with Gardner syndrome, syndromic features were not associated with any of the reports reviewed within our systematic analysis, likely owing to the predilection for mandibular angle rather than paranasal sinus osteomas in the multiple osteoma disorder. There was significant associated history of prior trauma or paranasal surgery with the osteoma group when compared to the osteoblastoma group-which relates to 1 of 3 (developmental, traumatic, or infectious) controversial proposed etiologies of this disease.…”

“…Its expansile nature leads to the destruction of the surrounding cortical bone and associated periostitis radiographically. 13 Pathologically, these tumors have been found with a "haphazard" arrangement of osseous trabeculae set in vascularized connective tissue stroma; osteoblasts or osteoclasts may predominate the immature bone leading to progressive mineralization of the entire bony tumor. 13 Osteoid osteomas closely resemble osteoblastomas histologically and therefore are oftentimes classified by size less than 2 cm.…”

“…13 Pathologically, these tumors have been found with a "haphazard" arrangement of osseous trabeculae set in vascularized connective tissue stroma; osteoblasts or osteoclasts may predominate the immature bone leading to progressive mineralization of the entire bony tumor. 13 Osteoid osteomas closely resemble osteoblastomas histologically and therefore are oftentimes classified by size less than 2 cm. The treatment of osteoid osteomas and osteoblastomas is total, en bloc, surgical excision, as they have local recurrence rates of greater than 20% with curettage and a rare possibility of malignant transformation.…”