Neoplasms in monkeys (Macaca mulatta): Spontaneous and irradiation induced

Kent, Sidney P.; Pickering, John E.

doi:10.1002/1097-0142(195801/02)11:1<138::aid-cncr2820110125>3.0.co;2-p

Cited by 89 publications

(23 citation statements)

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“…36 Since then, the development of brain tumors and other malignancies after irradiation in primates has primarily been observed in animals that underwent whole body irradiation. Dalrymple and colleagues 37 reported on a large series of Rhesus monkeys that were treated with whole body surface irradiation using non-fractionated schedules and lower doses (ionizing energies that would simulate the space radiation spectrum) than were used in this study.…”

Section: Discussionmentioning

confidence: 99%

Interspecies Comparative Genomic Hybridization (I-CGH): A New Twist to Study Animal Tumor Models

et al. 2007

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Animal models of human diseases are widely used to address questions of tumor development. Selection of a particular animal model depends upon a variety of factors, among them: animal cost, species lifespan and hardiness; availability of biomolecular and genetic tools for that species; and evolutionary distance from humans. In spite of the growth in genomic data in the past several years, many animal models cannot yet be studied extensively due to gaps in genetic mapping, sequencing and functional analyses. Thus, alternative molecular genetic approaches are needed.We have designed an interspecies comparative genomic hybridization approach to analyze genetic changes in radiation-induced brain tumors in the non-human primate, Macaca mulatta. Using homologies between the primate and human genomes, we adapted widely-available CGH techniques to generate cytogenetic profiles of malignant gliomas in four monkey tumors. Losses and gains were projected onto the corresponding homologous chromosomal regions in the human genome, thus directly translating the status of the monkey gliomas into human gene content. This represents a novel method of comparative interspecies cytogenetic mapping that permits simultaneous analysis of genomic imbalances of unknown sequences in disparate species and correlation with potential or known human disease-related genes.

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Section: Discussionmentioning

confidence: 99%

Interspecies Comparative Genomic Hybridization (I-CGH): A New Twist to Study Animal Tumor Models

et al. 2007

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“…These reports include a tumor of the anterior pituitary in a Macaca mulatta [ 5 ] , a tumor of the infundibular portion in a Cebus capucinus [ 11, and a chromophobe adenoma in a Macaca arctoides [8].…”

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A Sparsely Granulated, Nonsecreting Adenoma of the Pars Intermedia Associated with Galactorrhea in a Male Rhesus Monkey (Macaca mulatta)

1983

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Abstract. A pituitary mass was found at necropsy ofa maleMacma muluttu. Hematoxylin and eosin-stained sections were consistent with a chromophobe adenoma. Ultrastructural examination revealed the tumor to be comprised predominantly of sparsely granulated cells. The tumor cells were negative for prolactin, somatotropin, adrenocorticotropin, luteinizing hormone, and thyrotropin by the peroxidase anti-peroxidase method. Other major lesions were gynecomastia and galactorrhea, testicular atrophy, ankylosing spondylitis, and amyloid deposition in the liver, spleen, adrenal, and intestinal tract. This report describes the microscopic, ultrastructural, and immunohistochemical features of a nonsecreting, sparsely granulated chromophobe adenoma associated with galactorrhea in a Macaca mulatta. Case HistoryA male Mucuca mulutta (90-68) was received at the New England Regional Primate Research Center from another institution in January, 1968. In September, 1974, he was dehydrated and emaciated and had abdominal pain. A colon resection was done and approximately 15 cm of colon were removed. Chronic ulcerative colitis was diagnosed; recovery was complete. In December, 1979, a needle biopsy of liver was done as part of a study, and it was normal.In October, 1981, the monkey was sacrificed in poor condition. A complete blood count and serum chemistries were done about two weeks before death. The serum calcium was low (8.5 mg/dl), albumin was low (2.1 gm/dl), the globulin high (4.5 gm/dl), and the albumin/globulin ratio was reversed (0.5). The alkaline phosphatase and lactic dehydrogenase were elevated, 268 mU/ml and 342 mU/ml respectively All other values were normal. Hematology results were normal except for a mild anemia (hemoglobin: 10.0 gm/dl; hematocrit: 36.1 %).

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“…Naturally occurring fibromas or fibrosarcomas in the Rhesus monkey are rare. KENT and PICKERING [5] found a fibroma in the adrenal gland, and CHAPMAN [2] described a subcutaneous fibroma. Two examples of irradiation-induced, non-metastasizing fibrosarcomas in the Rhesus monkey have been reported [5], but ours is the first report of a naturally occurring fibrosarcoma with metastasis in this species.…”

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confidence: 99%