Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations

Kaplan, Ilana; Hodak, Emmilia; Ackerman, Lehavit; Mimouni, Daniel; Anhalt, Grant J.; Calderon, Shlomo

doi:10.1016/j.oraloncology.2003.09.020

Cited by 204 publications

(161 citation statements)

References 78 publications

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“…5,10,[24][25][26][27] Furthermore, hyaline vascular Castleman disease is well known to be associated with paraneoplastic pemphigus, a syndrome typically occurring in tumor patients. [28][29][30] It appears that hyaline vascular Castleman disease shares some neoplastic features.…”

Section: Discussionmentioning

confidence: 99%

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

et al. 2014

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Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor a (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia. We also assessed for immunoglobulin gene and T-cell receptor gene rearrangements, and conventional cytogenetic analysis was performed in three cases of hyaline vascular Castleman disease. In cases with informative results, conventional and methylation-specific human androgen receptor a gene analyses yielded a monoclonal pattern in 10 of 19 (53%) and 17 of 23 (74%) cases of hyaline vascular Castleman disease, respectively. A monoclonal pattern was also detected in three cases of plasma cell Castleman disease but not in cases of lymphoid hyperplasia. The frequency of monoclonality was higher for lesions 45 cm in size (100%) and for the stromal-rich variant (91%). Cytogenetic abnormalities in stromal cells were revealed in two cases of hyaline vascular Castleman disease and no cases showed monoclonal immunoglobulin or T-cell receptor gene rearrangements. Follow-up data showed persistent disease in 4 of 23 (17%) patients. We conclude that hyaline vascular Castleman disease is often a monoclonal proliferation, most likely of lymph node stromal cells.

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Section: Discussionmentioning

confidence: 99%

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

et al. 2014

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“…The condition is generally associated with a variety of hematologic and neoplastic disorders, such as Castleman's disease, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and epithelial cell carcinoma [2]. Suprabasal acantholysis and clefts with scattered necrotic keratinocytes are the typical histopathological cutaneous features.…”

Section: Discussionmentioning

confidence: 99%

“…A variety of associations of Castleman's disease, dendritic cell neoplasm and paraneoplastic pemphigus has been described [1,2,7]. But the simultaneous occurrence of these three rare diseases is exceptional.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic pemphigus associated with dendritic cell neoplasm and Castleman’s disease: report of a new case and review of the literature

et al. 2013

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“…97 Other less common associations include thymoma (6%), Waldenström's macroglobulinemia (WM) (1%), HL (,1%) and monoclonal gammopathy of uncertain origin (,1%). It is extremely resistant to therapy and portends a poor prognosis.…”

Section: Dermatologic Paraneoplastic Phenomenamentioning

confidence: 99%

Paraneoplastic Manifestations of Lymphoproliferative Neoplasms

2016

Lymphoma and Chronic Lymphocytic Leukemias

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Paraneoplastic syndromes, although rare, have been associated with lymphoproliferative disorders. Hodgkin's lymphoma (HL) is the most common lymphoid neoplasm known to cause paraneoplastic syndromes. These syndromes can often be the earliest manifestation of the underlying malignancy, and treating the underlying lymphoma can cure the paraneoplastic disease. Paraneoplastic diseases reported in lymphoid malignancies can be broadly classified into hematological, neurological, and dermatological syndromes based on the organ systems that are predominantly involved. In addition, renal and hepatobiliary involvement has also been reported. The pathogenesis of the hematological paraneoplastic conditions primarily involves the production of autoantibodies by the neoplastic lymphocytes, which then subsequently leads to cytopenias. Cytoses are a result of cytokine produced by the neoplasms. The administration of corticosteroids along with chemotherapy for the underlying malignancy is the treatment of choice. Neurological paraneoplastic phenomena have been reported in both HL and non-Hodgkin's lymphoma (NHL). They are thought to be secondary to an immune-related process that is triggered by the underlying process. Both the central and the peripheral nervous systems can be affected. Often, treatment of the underlying malignancy with chemotherapy can result in reversal of the paraneoplastic syndrome. In peripheral neuropathies, muscle relaxants and analgesics are often used for symptomatic relief. Dermatological manifestations, pemphigus vulgaris in particular, often precedes the malignancy. Renal and hepatobiliary manifestations, although rare, are also associated with lymphomas.

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Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations

Cited by 204 publications

References 78 publications

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

Paraneoplastic pemphigus associated with dendritic cell neoplasm and Castleman’s disease: report of a new case and review of the literature

Paraneoplastic Manifestations of Lymphoproliferative Neoplasms

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