Neoplasm or not? General principles of morphologic analysis of dry bone specimens

Ragsdale, Bruce D.; Campbell, Roselyn A.; Kirkpatrick, Casey L.

doi:10.1016/j.ijpp.2017.02.002

Cited by 54 publications

(48 citation statements)

References 27 publications

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“…Thus, there probably was an invasion into the medullar cavity. The pattern of margins can be described as invisible; the bone is encased by necrotic mass with increased density (Ragsdale, Campbell, & Kirkpatrick, In press). The type of periosteal reaction can be characterised as continuous with a destruction of underlying cortex (lobulated or ridge shell type; Ragsdale et al, in press).…”

Section: Resultsmentioning

confidence: 99%

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

Kufterin

Дубова

Nikiforovsky

2018

Intl J of Osteoarchaeology

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The article describes tumour‐like lesions in a Bronze Age skeleton from Southern Turkmenistan. The combination of pathological manifestations observed in the skeleton does not permit making exact conclusions. Based on the skeletal lesions, malignant bone tumour (chondrosarcoma or parosteal osteosarcoma) seems to be the most feasible diagnosis. If this diagnosis is correct, the skeleton represents one of the earliest cases of primary malignant tumours known to date.

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Section: Resultsmentioning

confidence: 99%

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

Kufterin

Дубова

Nikiforovsky

2018

Intl J of Osteoarchaeology

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“…; Bisseret et al., ; Ragsdale et al. ). In the study of dry bone sections of two osteosarcomas, De Boer & Maat () observed a combination of cortical and cancellous bone defects and periosteal depositions of the woven type.…”

Section: Discussionmentioning

confidence: 99%

“…Several hypotheses has been advanced to explain this type of bone formation (for an overview see Ragsdale et al. ; Wenaden et al. ; Rana et al.…”

Section: Discussionmentioning

confidence: 99%

“…This forms by slow apposition of layers of new bone (compact lamella) to cortex around an indolent lesion within the marrow space, in the cortex or in adjacent soft tissue (Ragsdale et al. ). It is described as a nonaggressive form primarily observed in slow and benign processes (Rana et al.…”

Section: Discussionmentioning

confidence: 99%

“…Most bone changes observed are circumscribed to disease‐related processes of circulatory, metabolic and mechanical stress origin (Ragsdale & Lehmer, ; Ragsdale et al. ). Bone tissue also has a limited number of ways to respond to internal or external assaults (Ragsdale & Lehmer, ), producing abnormalities of size, shape, density, bone formation and/or bone destruction (Ortner, , ).…”

Section: Introductionmentioning

confidence: 99%

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The macroscopic and histomorphological properties of periosteal rib lesions and its relation with disease duration: evidence from the Luis Lopes Skeletal Collection (Lisbon, Portugal)

Assis

Keenleyside

2019

Journal of Anatomy

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Periosteal new bone formation (PNBF) is a common finding in a large spectrum of diseases. In clinical practice, the morphology and location of periosteal lesions are frequently used to assist in the differential diagnosis of distinct bone conditions. Less commonly reported is the presence of PNBF on the ribs. This contrasts with the data retrieved from the study of skeletonized human remains that shows a high frequency of cases and a strong, albeit not specific, association between periosteal rib lesions and pulmonary conditions (e.g. tuberculosis). Despite that, an overall disagreement regarding the specificity and non‐specificity of periosteal reactions exists in the study of dry bone remains. The insufficient number of clinical models exploring the morphology and the pathophysiology of PNBF's and the lack of systematic studies of pathological samples with a known diagnosis are claimed as major reasons for the disagreements. This study aimed to describe and compare the macroscopic and the histomorphologic appearance of periosteal rib lesions and to discuss their usefulness as diagnostic indicators. To pursue this goal, an assemblage of 13 rib samples (males = 11, females = 2, mean age‐at‐death = 36.6 years old) was collected from the Luis Lopes Skeletal Collection (Museu Nacional de História Natural e da Ciência, Universidade de Lisboa, Portugal). The assemblage belongs to individuals who died from pulmonary‐TB (group 1), non‐TB pulmonary infections (group 2) and other conditions (group 3). Prior to sample preparation, the ribs were visually inspected and the PNBF described according to its thickness, the degree of cortical integration and the type of new bone formed (e.g. woven, lamellar or both). After sampling, each bone sample was prepared for histological analysis under plane and polarized light microscopy. Macroscopically, the results showed no differences in the new bone composition between cause‐of‐death groups. Only slight differences in the degree of cortical integration, which was most frequently classified as mild to high in the pulmonary‐TB group, were observed. Histologically, no distinguishing features were identified by pathological group. However, new bone microarchitectures were observed compatible with (1) acute, fast‐growing processes (e.g. spiculated reactions), (2) long‐standing processes with a rapid bone formation (e.g. appositional layering of bone) and/or (3) chronic, slow‐growing processes (e.g. layers of compact lamellae). To some extent, these distinct rates of disease progression resonate with the cause‐of‐death listed for some individuals. Despite the small sample size, the results of this investigation are in agreement with previous studies, according to which the macroscopic and histological appearance of periosteal formations are not specific for a particular pathological conditions. Nevertheless, the results support the conclusion that the morphology of periosteal lesions is a good biological indicator for inferring the rate of progression and duration of pathological...

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Inflammatory periosteal reaction on ribs associated with lower respiratory tract disease: A method for recording prevalence from sites with differing preservation

Davies-Barrett

Antoine

Roberts

2019

American J Phys Anthropol

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Objectives Inflammatory periosteal reaction (IPR) on the visceral surfaces of the ribs has been used in bioarchaeology as an indicator of lower respiratory tract disease. This article presents a detailed method for recording IPR on the ribs, even those in severely fragmented states, with the objectives of increasing the consistency of recording and producing true prevalence rates for skeletons so as to improve data comparability between future bioarchaeological studies of lower respiratory tract disease. Materials and methods The presence and prevalence of respiratory‐related IPR were recorded from three different Sudanese cemetery sites using a detailed method for identifying and recording IPR. Sites with variable preservation were chosen to test the applicability of the method. A flowchart to aid in identification of bony changes is presented. The method requires the recording of IPR on three separate sections of the rib (neck, angle, and shaft) and the allocation of ribs into rib cage regions of upper, upper‐middle, middle, lower‐middle, and lower. Results Results demonstrate differences in the distribution of IPR between sites and verify the method's applicability to archeological sites with various levels of skeletal preservation. Discussion While crude prevalence rates can indicate the number of individuals experiencing lower respiratory tract disease within a site, this method can provide information about the distribution of IPR within the rib cage. This should lead to new ways of distinguishing respiratory diseases within archeological populations. This method also allows for comparability between well‐preserved and lesser‐preserved sites by accommodating for rib fragmentation.

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Neoplasm or not? General principles of morphologic analysis of dry bone specimens

Cited by 54 publications

References 27 publications

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

The macroscopic and histomorphological properties of periosteal rib lesions and its relation with disease duration: evidence from the Luis Lopes Skeletal Collection (Lisbon, Portugal)

Inflammatory periosteal reaction on ribs associated with lower respiratory tract disease: A method for recording prevalence from sites with differing preservation

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