Neoplasia in Zoo Animals

Hubbard, Gene B.; Schmidt, R. E.; Fletcher, K. C.

doi:10.2307/20094627

Cited by 67 publications

(35 citation statements)

References 3 publications

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“…Evidence from captive, undomesticated animals, primarily in zoo populations, suggests that cancer may be responsible for about 1-5% of deaths [6][7][8][9]. But exposure to oncogenic agents and mortality from other causes likely differs between wild, captive and domestic populations.…”

Section: Introduction To Pervasiveness Of Cancer: Evolutionary Considmentioning

confidence: 99%

Infection and cancer in multicellular organisms

Ewald

2015

Phil. Trans. R. Soc. B

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Evolutionary considerations suggest that oncogenic infections should be pervasive among animal species. Infection-associated cancers are well documented in humans and domestic animals, less commonly reported in undomesticated captive animals, and rarely documented in nature. In this paper, we review the literature associating infectious agents with cancer to evaluate the reasons for this pattern. Non-malignant infectious neoplasms occur pervasively in multicellular life, but oncogenic progression to malignancy is often uncertain. Evidence from humans and domestic animals shows that non-malignant infectious neoplasms can develop into cancer, although generally with low frequency. Malignant neoplasms could be difficult to find in nature because of a low frequency of oncogenic transformation, short survival after malignancy and reduced survival prior to malignancy. Moreover, the evaluation of malignancy can be ambiguous in nature, because criteria for malignancy may be difficult to apply consistently across species. The information available in the literature therefore does not allow for a definitive assessment of the pervasiveness of infectious cancers in nature, but the presence of infectious neoplasias and knowledge about the progression of benign neoplasias to cancer is consistent with a widespread but largely undetected occurrence.

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Section: Introduction To Pervasiveness Of Cancer: Evolutionary Considmentioning

confidence: 99%

Infection and cancer in multicellular organisms

Ewald

2015

Phil. Trans. R. Soc. B

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“…Detailed studies on neoplasia in ophidian collections of zoological parks (Montali 1980;Griner 1983;Ramsay et al 1996;Catão-Dias and Nichols 1999;Sykes and Trupkiewicz 2006) demonstrated that the incidence of tumours in captive snakes is increasing and probably a result of longer life span due to improved husbandry and management (Ramsay et al 1996). Among ophidian species, frequently reported neoplasms include mesenchymal (Hubbard et al 1983), epithelial (Montali 1980;Ramsay et al 1996), and lymphoid/haematopoietic (Catão-Dias and Nichols 1999; Sykes and Trupkiewicz 2006). In snakes the liver has been found to be an organ frequently affected with neoplasms (Garner et al 2004;Sykes and Trupkiewicz 2006).…”

mentioning

confidence: 99%

Partial hepatectomy in a Plains garter snake (Thamnophis sirtalis radix) with biliary cystadenoma: case report

Knotek¹,

Grabensteiner²,

Knotková³

et al. 2012

Acta Vet. Brno

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A four-year-old, captive-bred, female Plains garter snake (Thamnophis sirtalis radix) was presented with a large midbody distension (5 cm × 3 cm × 3 cm) in the second third of the body length (total body length 123 cm). Contrast radiography technique excluded an envolvement of the oesophagus or stomach. Aspiration of 8 ml of acellular straw coloured fluid negative for presence of bacteria, fungi or parasites, reduced the swelling to a third of its original size. Surgical exploration revealed a pathologically changed central part of the liver with multiple different sized cysts. Histopathologically the diagnosis was defined as biliary cystadenoma. As the liver had a physiological appearance cranial and caudal to the central area, a partial hepatectomy was performed. The snake recovered well and started to feed spontaneously two days after surgery. During the check up two, four and seven months after hepatectomy, the snake was active and in a good condition. Hypoproteinaemia and altered activity of lactate dehydrogenase were present two months after surgery, azurophilia and hyperuricaemia were present in the blood sampled four months after hepatectomy. Except for azurophilia, the other values of the blood profile were within the expected range for a healthy snake seven months after surgery, indicating full recovery. This is the first detailed report of a successful central resection of a large pathologically changed part of the liver in snakes which was diagnosed as biliary cystadenoma.

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“…16 The most commonly reported ophidian neoplasms are mesenchymal, 7,8 epithelial, 7,16 and lymphoid/hematopoietic. 2,7 Most reported neoplasms among ophidian species are in aged colubrids, followed by crotalids, vipers, and boids.…”

mentioning

confidence: 99%

Endocardial Fibrosarcoma in a Reticulated Python (Python Reticularis)

2010

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Abstract. A female, reticulated python (Python reticularis) of unknown age was presented with a history of lethargy, weakness, and distended coelom. Physical examination revealed severe dystocia and stomatitis. The reticulated python was euthanized due to a poor clinical prognosis. Postmortem examination revealed marked distention of the reproductive tract with 26 eggs (10-12 cm in diameter), pericardial effusion, and a slightly firm, pale tan mass (3-4 cm in diameter) adhered to the endocardium at the base of aorta. Based on histopathologic and transmission electron microscopic findings, the diagnosis of endocardial fibrosarcoma was made.

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Neoplasia in Zoo Animals

Cited by 67 publications

References 3 publications

Infection and cancer in multicellular organisms

Infection and cancer in multicellular organisms

Partial hepatectomy in a Plains garter snake (Thamnophis sirtalis radix) with biliary cystadenoma: case report

Endocardial Fibrosarcoma in a Reticulated Python (Python Reticularis)

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