Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

Tosun, Fâtma; Mıhoğlugil, Feyyaz; Beutler, John A.; Özkan, Esra Eroğlu; Miski, Mahmut

doi:10.3390/molecules25133040

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…The compound induced apoptosis in HeLa and SiHa cervical cancer cells by enhancing reactive oxygen species (ROS) generation while increasing the expression of cytochrome c and other apoptotic proteins. Palmatine and 6-methoxydihydroavicine isoquinoline alkaloids were isolated from Berberis cretica and Macleaya cordata , respectively [ 28 , 51 ]. Reports by Ma et al [ 28 ] and Zhang et al [ 27 ] suggest that 6-methoxydihydroavicine increased cellular ROS generation and interfered with mitochondria oxaloacetic acid metabolism during glycolysis in pancreatic and ovarian carcinoma cancer cells.…”

Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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Cancer is a neoplastic disease that remains a global challenge with a reported prevalence that is increasing annually. Though existing drugs can be applied as single or combined therapies for managing this pathology, their concomitant adverse effects in human applications have led to the need to continually screen natural products for effective and alternative anticancer bioactive principles. Alkaloids are chemical molecules that, due to their structural diversity, constitute a reserve for the discovery of lead compounds with interesting pharmacological activities. Several in vitro studies and a few in vivo findings have documented various cytotoxic and antiproliferative properties of alkaloids. This review describes chaetocochin J, neopapillarine, coclaurine, reflexin A, 3,10-dibromofascaplysin and neferine, which belong to different alkaloid classes with antineoplastic properties and have been identified recently from plants. Despite their low solubility and bioavailability, plant-derived alkaloids have viable prospects as sources of viable lead antitumor agents. This potential can be achieved if more research on these chemical compounds is directed toward investigating ways of improving their delivery in an active form close to target cells, preferably with no effect on neighboring normal tissues.

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Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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“…Renal cell cancer is the most invasive malignant tumor of the urinary system and accounts for 2-3% of malignant tumors in adults (Lee et al, 2021). Tosun et al (2020) found that osthole exerted selective cytotoxic activities in a renal cell cancer cell line (A498, UO31).…”

Section: Urinary Systemmentioning

confidence: 99%

Osthole: An up-to-date review of its anticancer potential and mechanisms of action

et al. 2022

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With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various cancer treatment options has been the focus of many domestic and international researchers, and significant progress has been made in the study of the anticancer effects of traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has become a new research hotspot. There have been many reports on its anticancer effects, and recent studies have elucidated that its underlying mechanism of action mainly involves inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting invasion and migration of cancer cells, inhibiting cancer angiogenesis, increasing sensitivity to chemotherapy drugs, and reversing multidrug resistance of cancer cells. This mini-review summarizes the research progress on the anticancer effects of osthole in recent years.

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“…It has many active biological properties, such as antioxidant, antiinflammatory, antiviral, antibacterial, antifungal and anticancer activities [256][257][258]. To-sun et al [123] found that neopapillarine decreased cell growth in A498 and UO31 RCC cell lines, although mechanisms were not specified.…”

Section: Neopapillarinementioning

confidence: 99%

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

Bajalia

Azzouz

Chism

et al. 2022

Cancers

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Renal cell carcinoma (RCC) is associated with about 90% of renal malignancies, and its incidence is increasing globally. Plant-derived compounds have gained significant attention in the scientific community for their preventative and therapeutic effects on cancer. To evaluate the anticancer potential of phytocompounds for RCC, we compiled a comprehensive and systematic review of the available literature. Our work was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. The literature search was performed using scholarly databases such as PubMed, Scopus, and ScienceDirect and keywords such as renal cell carcinoma, phytochemicals, cancer, tumor, proliferation, apoptosis, prevention, treatment, in vitro, in vivo, and clinical studies. Based on in vitro results, various phytochemicals, such as phenolics, terpenoids, alkaloids, and sulfur-containing compounds, suppressed cell viability, proliferation and growth, showed cytotoxic activity, inhibited invasion and migration, and enhanced the efficacy of chemotherapeutic drugs in RCC. In various animal tumor models, phytochemicals suppressed renal tumor growth, reduced tumor size, and hindered angiogenesis and metastasis. The relevant antineoplastic mechanisms involved upregulation of caspases, reduction in cyclin activity, induction of cell cycle arrest and apoptosis via modulation of a plethora of cell signaling pathways. Clinical studies demonstrated a reduced risk for the development of kidney cancer and enhancement of the efficacy of chemotherapeutic drugs. Both preclinical and clinical studies displayed significant promise of utilizing phytochemicals for the prevention and treatment of RCC. Further research, confirming the mechanisms and regulatory pathways, along with randomized controlled trials, are needed to establish the use of phytochemicals in clinical practice.

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Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

Cited by 7 publications

References 32 publications

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

Osthole: An up-to-date review of its anticancer potential and mechanisms of action

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

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