“…According to Özalkaya et al TOS is much higher in cases of premature rupture of membranes and TAS is lower in cases of premature rupture of membranes and fetal inflammatory response syndrome. Also, they suggest that oxidative stress is responsible for the premature ageing of the fetal membranes of infants born before 34 weeks of gestation (57). This thesis is also supported by a number of studies carried out by Menon and Richardson (58) and Ilhan et al (59).…”
Section: Circulating Biomarkers and Oxidative Stress Evaluationmentioning
Pregnancy, labor and childbirth are accompanied by excessive oxidative aggression. The excessive formation of free radicals [reactive oxygen species (ROS), reactive nitrogen species (RNS), chlorine reactive species (CRS)] causes cellular oxidative damage, which can be scavenged by enzymatic or non-enzymatic antioxidants in normal healthy pregnancy, physiological labor and delivery without any complications. An imbalance between the pro-oxidant and antioxidant factors may lead to oxidative stress, which contributes to the development of many diseases. This oxidative aggression can be a precursor for pathologies in the pregnant woman including eclampsia, miscarriage, preterm labor, and intrauterine growth retardation; in the offspring it may lead to bronchopulmonary dysplasia/chronic lung disease, necrotizing enterocolitis, retinopathy of prematurity, and periventricular leukomalacia. This review summarizes the studies conducted to identify the mechanisms of oxidative stress and the effect of cell membrane oxidation, the mechanisms that are behind oxidative stress-related diseases, and also those studies which have demonstrated the effect of antioxidants in preventing diseases or diminishing the effects of oxidative stress in the body, in obstetrics and neonatology.
“…According to Özalkaya et al TOS is much higher in cases of premature rupture of membranes and TAS is lower in cases of premature rupture of membranes and fetal inflammatory response syndrome. Also, they suggest that oxidative stress is responsible for the premature ageing of the fetal membranes of infants born before 34 weeks of gestation (57). This thesis is also supported by a number of studies carried out by Menon and Richardson (58) and Ilhan et al (59).…”
Section: Circulating Biomarkers and Oxidative Stress Evaluationmentioning
Pregnancy, labor and childbirth are accompanied by excessive oxidative aggression. The excessive formation of free radicals [reactive oxygen species (ROS), reactive nitrogen species (RNS), chlorine reactive species (CRS)] causes cellular oxidative damage, which can be scavenged by enzymatic or non-enzymatic antioxidants in normal healthy pregnancy, physiological labor and delivery without any complications. An imbalance between the pro-oxidant and antioxidant factors may lead to oxidative stress, which contributes to the development of many diseases. This oxidative aggression can be a precursor for pathologies in the pregnant woman including eclampsia, miscarriage, preterm labor, and intrauterine growth retardation; in the offspring it may lead to bronchopulmonary dysplasia/chronic lung disease, necrotizing enterocolitis, retinopathy of prematurity, and periventricular leukomalacia. This review summarizes the studies conducted to identify the mechanisms of oxidative stress and the effect of cell membrane oxidation, the mechanisms that are behind oxidative stress-related diseases, and also those studies which have demonstrated the effect of antioxidants in preventing diseases or diminishing the effects of oxidative stress in the body, in obstetrics and neonatology.
“…The studies that reported a positive association between oxidative stress and/or development of diseases related to prematurity were 72.2% (n = 13); 27.7% (n = 5) showed no significant association. Positive correlations were found in IUGR; 8 , 13 , 25 NEC; 10 , 20 morbidity and mortality; 5 , 26 BPD, IVH; 10 FIRS; 21 early-onset neonatal sepsis; 22 RDS 12 and ROP. 27 CLD, 19 DNA damage, 4 IVH, 24 cardiac functions, 23 and endothelial dysfunction 9 were not associated with oxidative stress levels in included studies.…”
Section: Resultsmentioning
confidence: 92%
“…Synthesis of the articles, year of publication, type of study, sample, source of specimen, biomarkers, diseases evaluated, and the main outcomes are described in Table 1 . 3 , 4 , 5 , 8 , 9 , 10 , 12 , 13 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 Figure 1 Flowchart of the study selection process for the integrative review on oxidative stress in premature newborns. …”
Section: Resultsmentioning
confidence: 99%
“… Norishadkam et al, 2017 4 Iran Case-control study 50 NB 25 PTN 25 FT NB Cord blood MDA Catalase SOD TAC DNA damage There was no significant association between MDA, SOD, TAC, catalase, and early DNA damage in cord blood plasma for PTN. Ozalkaya et al, 2017 21 Turkey Prospective 51 PTN Cord blood TAC PON-1 TOS OSI FIRS RDS IVH BPD ROP Sepsis Higher levels of TOS were associated with NB with PPROM; Higher PON-1 was associated with higher risk of PPROM, FIRS or both. NB with PPROM and FIRS had higher incidence of RDS.…”
“…Furthermore, higher level of oxidative stress and lower level of anti-oxidant capacity markers were observed in women with PPROM with consequent histological chorioamnionitis as compared with PPROM but without chorioamnionitis. Özalkaya et al demonstrated that umbilical cord pro-oxidant TOS level was higher in preterm infants without fetal inflammatory response syndrome (FIRS) and with PPROM compared to those without FIRS and PPROM (67).…”
Section: A C C E P T E D Accepted Manuscriptmentioning
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