Neonate With Late Onset Streptococcus Bovis Meningitis: Case Report and Review of the Literature

A Longitudinal Case Series Description of Meningitis Due to Streptococcus gallolyticus subsp. pasteurianus in Infants

“…Initial laboratory values included a complete blood count (CBC), with a white blood cell (WBC) count of 6,570/mm 3 , with 37% neutrophils, 33% lymphocytes, 23% monocytes, and 3% eosinophils, a hemoglobin level of 17 g/dl, and a platelet count of 382,000/mm 3 . Cerebrospinal fluid (CSF) revealed a glucose level of 35 mg/dl, a protein level of 60 mg/dl, a red blood cell (RBC) count of 23/mm 3 , and a WBC count of 13/mm 3 . CSF Gram staining exhibited no organisms and rare WBCs.…”

“…S. bovis has not been studied as extensively in children, and studies in which the organism has been identified to the subspecies level in children are rare. Sporadic case reports, including those by Cheung et (3,8,10). Recently, Floret et al described a cluster of five infections due to S. gallolyticus subsp.…”

Late-onset Streptococcus pasteurianus sepsis in a preterm baby in a neonatal intensive care unit

“…In large case series, it has been demonstrated that group D streptococci are the responsible agent only in 5-6% of the cases and most of these cases arise from enterococci (3)(4)(5)(6). There is a small number of case presentations where S.bovis which is one of Group D streptococci is the agent of neonatal sepsis and/or meningitis.…”

“…There is a small number of case presentations where S.bovis which is one of Group D streptococci is the agent of neonatal sepsis and/or meningitis. However, the real incidence may be higher than known, because S. bovis was erroneously defined as enterococcus or S. viridans in previous years (1,5). In addition, multiple taxonomic transformation of S. bovis has caused to uncertainity and confusion.…”

“…The number of publications where the causative agent was reported to be S. bovis type II/2 or S. pasteurianus was seven and the total number of cases was 14 (one publication included five cases, one publication included four cases and the other publications included single cases) (1,5,(7)(8)(9)(10)(11). When these cases were examined, it was noted that term and preterm babies were affected equally, early and late infection rates were similar, but early infection was observed in term babies and late infection was observed in preterm babies, no risk factor was present for early and late sepsis, meningitis accompanied 64% of the cases and meningitis was mostly observed in the patients in whom early infection was developed and was manifested with clinical findings similar to group B sterptococci and E. coli infections.…”