Neonatally Androgenized Females' Responsiveness to Estrogen and Progesterone

Gerall, Arnold A.; Kenney, Ann McM.

doi:10.1210/endo-87-3-560

Cited by 43 publications

(12 citation statements)

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“…This finding was unexpected because other workers have reported that neonatal TP treatment decreases adult sensitivity to OB as measured by the display of lordosis (Edwards & Thompson, 1970;Gerall & Kenney, 1970;Whalen, Luttge & Gorzalka, 1971). It is possible that the failure to replicate these previous findings with the present procedures was due to the fact that TP was given on day 4 of life which may have been too late.…”

Section: Resultsmentioning

confidence: 85%

Lordosis Behaviour in Male, Female and Androgenized Female Rats

Södersten¹

1976

Journal of Endocrinology

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Sex differences in the lordodis response of adult rats to ovarian hormones were studied in a series of experiments. Male rats were less sensitive to oestradiol benzoate (OB, a single injection of 10, 100 or 1000 mug/kg or seven daily injections of 2, 10, or 50mglkg)then were female rats. Oestradiol benzoate-primed (10 mglkg)female, but not male, rats showed dose-dependent responses to progesterone (0-4, 2-0 or 10-0 mg/kg/. male rats responded clearly to progesterone (2 mg/rat) only when primed with a high dose of OB (100 mug/rat). Display of the whole pattern of female sexual behaviour was induced in male rats by treatment with 100 mug OB and 2 mg progesterone. Female rats treated with 1 mg testosterone propionate (TP) on day 4 of life, ovariectomized as adults and tested under the same endocrine conditions as the rats described above, retained behavioural OB sensitivity but responded poorly to progesterone. Evidence is presented that ovarian secretions during development significantly modify the response of neonatally TP-treated and normal female rats to OB in adulthood.

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Section: Resultsmentioning

confidence: 85%

Lordosis Behaviour in Male, Female and Androgenized Female Rats

Södersten¹

1976

Journal of Endocrinology

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“…Our data, indicating that neonatal castration [263] as well as neonatal androgenization that postpones sexual maturation, as evidenced by delayed vaginal opening [264,265] , delays the onset of thymic involution [Leposavic et al, in preparation] may speak in favor of this hypothesis. However, it has been demonstrated that neither cellularity of main thymocyte subsets (followed from age 3 to 10 months) nor overall thymic cellularity (followed from age 3 to 18 months) significantly differed at any point examined between hypogonadal mice and their normal HPG/Bm-hpg/hpg (hpg) littermates [51] .…”

Section: Reassessment Of Sex Steroid Role In Thymus Agingmentioning

confidence: 77%

Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

Leposavić

Perišić

2008

Neuroimmunomodulation

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The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via α- and β-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered.

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“…It has subsequently been demonstrated that these masculinized rats have polyfollicular non-ovulatory ovaries devoid of corpora lutea and are permanently sterile (Gerall & Kenny, 1970;McDonald & Doughty, 1972). Behaviourally the androgenized female demonstrates enhanced male sexual behaviour (Baum, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…TP is only effective when administered during the first 10 days post-parturition, implying the existence of a specific androgen-sensitive period in the female pup for the development of organizational effects (Barraclough, 1961). The resultant androgenized female has an increased body weight (Swanson & Van Der Werff Ten Bosch, 1963;Tartellin et al 1975), polyfollicular non-ovulatory ovaries devoid of corpora lutea (Gerall & Kenny, 1970;J Physiol 563.1 McDonald & Doughty, 1972), enhanced male sexual behaviour (Baum, 1979) and a failure to display the lordosis response when sexually active (Harris & Levine, 1965). It has been proposed that the morphological changes in the ovaries of masculinized rats result from disrupted gonadotrophin regulation by the CNS (Pfeiffer, 1936;Barraclough, 1962).…”

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confidence: 99%

Postnatal masculinization alters the HPA axis phenotype in the adult female rat

Seale¹,

Wood²,

Atkinson³

et al. 2005

The Journal of Physiology

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The ability of postnatal testosterone propionate (TP) to masculinize both behaviour and gonadal cyclicity in the female rat is well documented. We have investigated whether postnatal androgen also has an organizational effect on another sexually dimorphic neuroendocrine system -the hypothalamo-pituitary-adrenal (HPA) axis. Female rats were exposed to a single injection of testosterone propionate (TP) or oil within 24 h of birth. As adults, rats were either ovariectomized and given 17β-oestradiol replacement (OVXE 2 ) or sham ovariectomized with cholesterol implants (SHOVX). An automated sampling system collected blood from unanaesthetized adult female rats every 10 min over a 24-h period, during a mild psychological stress (noise) and following an immunological lipopolysaccharide stress (LPS). Neonatal TP-treated SHOVX rats had a significant reduction in the number, height, frequency and amplitude of corticosterone pulses over the basal 24-h period, compared to both the neonatal oil-treated and TP-treated OVXE 2 animals. The corticosterone response to both noise and LPS was also significantly decreased for the TP-treated SHOVX females. Three hours post-LPS administration, TP females had significantly lower values of paraventricular nucleus (PVN) corticotrophin releasing hormone (CRH), arginine vasopressin (AVP) and anterior pituitary proopiomelanocortin (POMC) mRNAs and greater PVN glucocorticoid receptor (GR) mRNA expression compared to the oil-treated controls. E 2 replacement in adult TP rats normalized all the mRNA levels, except for PVN GR mRNA which did fall towards the levels of the oil-control animals. A single injection of TP within 24 h of birth disrupts the development of the characteristic female pattern of corticosterone secretion and the normal female HPA response to stress, resulting in a pattern similar to that seen in males. These effects can be reversed by E 2 treatment in the adult TP female rat.

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Neonatally Androgenized Females' Responsiveness to Estrogen and Progesterone

Cited by 43 publications

References 1 publication

Lordosis Behaviour in Male, Female and Androgenized Female Rats

Lordosis Behaviour in Male, Female and Androgenized Female Rats

Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

Postnatal masculinization alters the HPA axis phenotype in the adult female rat

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