Neonatal zygomycosis with gastric perforation

Mathur, N. B.; Gupta, Amit

doi:10.1007/s13312-013-0176-z

Cited by 6 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that the immature vascular bed may participate in the development of NGP, as supported by the association of NGP with necrotizing enterocolitis or NSAID administration ( 6 , 61 ). Finally, neonates, particularly preterm ones, may present increased susceptibility to infectious complications, both bacterial and fungal, that have been associated with the development of gastric perforation ( 9 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature

et al. 2018

View full text Add to dashboard Cite

IntroductionNeonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors.Materials and methodsRetrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy. All articles referring to NGP published between 2005 and 2017 were retrieved. Variables considered: prematurity (<37 weeks gestation), birth weight (BW), Apgar score, prenatal complications, age at diagnosis, bag ventilation, pathogenetic events, site of perforation, treatment of perforation, sepsis, and outcome. Mann–Whitney or Fisher’s test were used as appropriate. Results are median (range) or prevalence.ResultsBetween 2009 and 2016 we treated 8 consecutive patients for NGP and 199 further cases were retrieved from the systematic review (total of 207 patients). Overall survival was 73%. Most frequently reported pathogenesis: iatrogenic (20 patients), hypoxic/ischemic or infection stress (13 patients), duodenal/jejunal obstruction (11 patients), drugs (11 patients), esophageal atresia (10 patients). 60% patients had only primary repair of the perforation as gastric surgery. Sepsis developed in 56 patients (34%).ConclusionAlthough the pathogenesis of NGP is pleomorphic, prematurity and low BWs are frequent in these patients. Reviewing our experience and the available literature, none of the variables considered, but sepsis was associated with mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Other risk factors previously reported include NEC, septicemia, lactobezoar, and zygomycosis. [24][25][26] Patient 7 had a lactobezoar, while patient 9 had NEC involving the stomach, duodenum, and proximal jejunum.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Gastric Perforation: 14-Year Experience from a Tertiary Neonatal Intensive Care Unit

Sakaria

Zaveri

2021

Am J Perinatol

View full text Add to dashboard Cite

Objective Neonatal gastric perforations (NGPs) are rare and account for 7 to 12% of all gastrointestinal perforations in the neonatal period. The etiology and prognostic factors associated with NGP remain unclear. The aim of this study is to review the cases of NGP in our neonatal intensive care unit (NICU) in the past 14 years and describe the risk factors, clinical presentation, and outcomes associated with it. Study Design A retrospective chart review of neonates with gastric perforation admitted to the NICU between June 2006 and December 2020 was performed. Data regarding their antenatal and neonatal characteristics, laboratory and radiological results, intra-operative findings, hospital course, and outcomes were recorded. Results We identified 350 patients with gastrointestinal perforation at our center during the study period of which 14 (4%; nine males and five females) patients were diagnosed with NGP during surgery. A total of 71% neonates were born preterm (range: 24–39 weeks, median: 34 weeks). Two neonates (14%) were SGA. Only one neonate received cardiopulmonary resuscitation at birth. In all neonates, except two, perforation occurred within the first 10 days of life (median: 4 days, range: 1–22 days). In total, 79% infants received feeds prior to perforation. Ten neonates had a feeding tube, and one neonate had a gastrostomy tube placed prior to perforation. Abdominal distension and pneumoperitoneum were present in all neonates. Majority of the babies had metabolic acidosis (64%) and elevated C-reactive protein (79%). Most (86%) neonates received surgical intervention within 12 hours. Overall survival in our study was 93%. Conclusion NGP is a rare entity seen mostly in preterm infants within the first 10 days of life. Clinical presentation is similar to perforation anywhere along the gastrointestinal tract and definite diagnosis requires exploratory laparotomy. With prompt recognition and surgical intervention, the overall mortality related to neonatal gastric perforation is low. Key Points

show abstract

“…As Mucorale belongs to class Zygomycetes (under phylum Zygomycota), mucormycosis is also referred to, somewhat incorrectly, as zygomycosis. [2,3,4] They are ubiquitous saprophytic moulds that can cause invasive infection in immunocompromised individuals. Preterm neonates with immature immune system are more vulnerable for GIMN.…”

mentioning

confidence: 99%

Gastrointestinal Mucormycosis Mimicking Necrotizing Enterocolitis of Newborn

Raveenthiran

2013

J Neonatal Surg

View full text Add to dashboard Cite

show abstract

Neonatal zygomycosis with gastric perforation

Abstract: Zygomycosis is a rare infection in neonates. The clinical presentation is non-specific and diagnosis most often is made at autopsy. Surgical debridement performed early improves survival. We report a case of neonatal zygomycosis with gastric perforation.

Cited by 6 publications

References 6 publications

Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature

Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature

Neonatal Gastric Perforation: 14-Year Experience from a Tertiary Neonatal Intensive Care Unit

Gastrointestinal Mucormycosis Mimicking Necrotizing Enterocolitis of Newborn

Contact Info

Product

Resources

About