Neonatal Vaccination with Plasmid DNA Encoding Cyn d 1 Effectively Prevents Allergic Responses in Mice

Abstract

This study shows the prophylactic effects of DNA vaccine encoding Bermuda grass pollen allergen Cyn d 1 on specific IgE responses in neonatal mice.

Editorial: The Pathophysiology of Sinonasal Conditions and Novel Therapeutic Options

“…The current issue of the American Journal of Rhinology and Allergy is notable for articles investigating the pathogenesis of allergic rhinitis (AR). A provocative study by Huang and colleagues 12 addressed the issue of prevention of allergen sensitization. They used the knowledge that recombinant DNA plasmids encoding allergens may activate Th1 and dampen Th2 responses by injecting recombinant plasmid Cyn d 1 in neonatal BAL/c mice.…”

“…A provocative study by Huang and colleagues 12 addressed the issue of prevention of allergen sensitization. They used the knowledge that recombinant DNA plasmids encoding allergens may activate Th1 and dampen Th2 responses by injecting recombinant plasmid Cyn d 1 in neonatal BAL/c mice.…”