Neonatal urinary uric acid/ceratinine ratio as an additional marker of perinatal asphyxia

Bader, David A.; Gozal, David; Weinger-Abend, Marta; Berger, Anna; Lanir, Amos

doi:10.1007/bf02276720

Cited by 32 publications

(22 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another study by Bader et al [13] showed that UA/Cr was higher in the asphyxiated group when compared to controls. (2,06+1.12, vs. 0.64+0.48; P<0.001) which is also similar to our study.…”

Section: Discussionmentioning

confidence: 93%

Study of Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Correlation with Different Stages of Hypoxic Ischemic Encephalopathy

Choudhary¹,

Palsania²,

Berwal³

et al. 2017

J Preg Child Health

View full text Add to dashboard Cite

Background: Birth asphyxia is one of the leading causes of neonatal mortality in India. Hypoxic-ischemic encephalopathy (HIE) is the neurological manifestation of systemic hypoxia in new-born. 20-25% of asphyxiated babies who exhibit severe HIE, die during the new-born period. The most commonly used diagnostic and prognostic index to evaluate asphyxia in neonates is APGAR score but alone it is not useful to ferret out neurological outcome. Now-a-days uses of biomarkers enable the clinicians to screen infants for brain injury. We conducted this study to evaluate the role of UUA (urinary uric acid)/Cr (creatinine), which is an early biomarker, in diagnosing and predicting the outcome in perinatal asphyxia.

show abstract

“…Another study by Bader et al [13] showed that UA/Cr was higher in the asphyxiated group when compared to controls. (2,06+1.12, vs. 0.64+0.48; P<0.001) which is also similar to our study.…”

Section: Discussionmentioning

confidence: 93%

Study of Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Correlation with Different Stages of Hypoxic Ischemic Encephalopathy

Choudhary¹,

Palsania²,

Berwal³

et al. 2017

J Preg Child Health

View full text Add to dashboard Cite

show abstract

“…Results correlate with present study. 12 In study by Chen et al found that urinary UA/CR ratio was higher in the asphyxiated group compared to controls. This result supports present study.…”

mentioning

confidence: 94%

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

Sreekrishna

Eregowda

Sharma

2018

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Every hour, 104 children die as a result of asphyxia. In India; between 250,000 to 350,000 infants die each year secondary to birth asphyxia and mostly within the first three days of life. The present study was performed to determine the Urinary Uric Acid to Creatinine Ratio in perinatal asphyxia and its correlation between APGAR score and urinary uric acid to creatinine ratio in perinatal asphyxia.Methods: A randomized case control hospital-based study was conducted on 50 asphyxiated and 50 normal newborn. Urinary uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between the concentrations of uric acid to creatinine was estimated and comparison done between cases and controls.Results: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.Conclusions: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.

show abstract

“…(6,12) These positive results may help the clinicians to identify the etiology of convulsions without history of asphyxia.…”

Section: Discussionmentioning

confidence: 95%

“…(6) Despite the increasing understanding of the mechanisms leading to and resulting from perinatal asphyxia early determination of brain damage following hypoxic ischemic events still remains one of the hardest problems in neonatal care. (1) Their clinical manifestation, their individual potentials to respond to the asphyxia insult to recover vary among the newborns.…”

Section: Discussionmentioning

confidence: 99%

“…(3,5) The diagnosis and evaluation of perinatal asphyxia is problematic and objective means of assessing the severity are lacking. (6) There are no specific criteria to identify the neonate with asphyxia who are at a greater risk for encephalopathy and therefore most likely to be benefitted from newer intervention. (7) On followup there are no standard guidelines to determine which babies suffered an asphyxia insult during birth.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Study on Anti-Dyslipidemic Activities (Lipid Profile) of Extracts of Gloriosasuperba, Valerian Wallichi and Odenlandiacorymbosa

Awasthi¹

2017

JMSCR

View full text Add to dashboard Cite

Neonatal urinary uric acid/ceratinine ratio as an additional marker of perinatal asphyxia

Abstract: Infants with perinatal asphyxia have a significantly higher urinary UA/Cr ratio. This may be used as an indicator of the severity of perinatal asphyxia.

Cited by 32 publications

References 12 publications

Study of Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Correlation with Different Stages of Hypoxic Ischemic Encephalopathy

Study of Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Correlation with Different Stages of Hypoxic Ischemic Encephalopathy

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

A Study on Anti-Dyslipidemic Activities (Lipid Profile) of Extracts of Gloriosasuperba, Valerian Wallichi and Odenlandiacorymbosa

Contact Info

Product

Resources

About