Neonatal undernutrition and self-grooming development in the rat: Long-term effects

Salas, Manuel; Pulido, Susana; Torrero, Carmen; Escobar, Carolina

doi:10.1016/0031-9384(91)90547-2

Cited by 16 publications

(7 citation statements)

References 25 publications

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“…In this regard, projec tions from the visual cortex to the claustrum originating in the fourth layer and returning from the claustrum to the same cortical areas to layers IV and VI establishing a reciprocal modulator circuit, which may regulate senso ry influx to this zone [ 18], In undernourished rats the reduced dendritic arbor in the claus tral neurons may generate a deficient regula tory process that may be associated with inad equate locomotion [28,29] or with impaired visuospatial integration as observed in be 52 Escobar/Salas Neonatal Undemutrition and Claustrum Development havioral studies [30][31][32], This possibility is strengthened by data showing the high vulner ability of polysensory nervous structures to perinatal undernutrition in the thalamus [1,9], the amygdala [5], the hippocampus [3, 33,34], the cerebellar granular layer [35] and the intemeurons of the cerebral cortex [36], How ever, further morphological and behavioral studies will be needed in order to corroborate this proposal.…”

Section: Resultsmentioning

confidence: 99%

Dendritic Branching of Claustral Neurons in Neonatally Undernourished Rats

Escobar

Salas

1995

Neonatology

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Golgi-Cox-impregnated neurons of the claustrum were studied in control and undernourished Wistar strain rats at 12, 20, and 40 days of age. A reduced cross-sectional somatic area was observed in the 20-day-old undernourished rats and a significant reduction in the dendritic area was observed in the three ages studied. Dendritic arbor alteration was mainly observed in the number of high order and in the total number of dendritic branches of undernourished rats throughout the study. The data suggest vulnerability of the dendritic claustral growth process during the postnatal period to neonatal undernutrition. These alterations may be associated with telencephalic integrative impairments described in perinatal undernourished rats.

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Section: Resultsmentioning

confidence: 99%

Dendritic Branching of Claustral Neurons in Neonatally Undernourished Rats

Escobar

Salas

1995

Neonatology

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“…It might be assumed, therefore, that perinatal insults such as early sensory deprivation and undernutrition could interfere with the development of central modulatory mechanisms underlying sensory transmission. Indirect evidence of this is manifold: a significant increment in self-grooming and exploratory behavior [14,15], the dendritic arbor alterations in neurons of the thalamic reticular nucleus of the rat which are closely related to the control of visual afferent transmission [16,17], the prolonged attenuation of electrical potentials to repetitive auditory stimulation at different frequencies [18], and the increased duration of provoked mitral cell electrical responses elicited by tetanic stimulation [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of Neonatal Undernutrition and Binaural Ear Occlusion on Neuronal Development of the Superior Olivary Complex of Rats

et al. 1999

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Golgi-Cox-impregnated neurons of the superior olivary complex were investigated in control, binaural ear-occluded control, undernourished, and binaural ear-occluded undernourished Wistar rats of 12, 20, and 30 days of age. In neonatally undernourished and binaural ear-occluded animals, a significant reduction in the number of dendrites and dendritic intersections in the medial trapezoid body neurons was observed. Inconsistent effects upon the dendritic arbor lateral superior olivary cells were also detected. Control and undernourished rats with binaural ear occlusion exhibited a significant increase in the dendritic arbor measurements of lateral superior olivary neurons as compared with the cells of the medial trapezoid body. The cytoarchitectonic imbalance between the modulatory efferent control of these systems and the sensory auditory input to the cochlea may be important for the integration of complex auditory physiological phenomena.

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“…e food-deprived mothers showed a longer period of exploratory behaviour and needed a longer time to retrieve their pups as compared with the well-fed mothers (Massaro et al, 1974). As proved by delayed ear and eye opening (Salas et al, 1991) the sensorial system is particularly sensitive to perinatal undernutrition. e central nervous system of neonatal rats is considered to be immature in almost all aspects.…”

Section: Discussionmentioning

confidence: 96%

Effect of early nutritional experience on the feeding behaviour of adult female rats

Šefčíková¹,

Mózeš²

2002

Vet. Med. - Czech

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In the present paper the effect of postnatal undernutrition on feeding behaviour has been evaluated in mature female Wistar rats subjected to food restriction a) during the suckling period, i. e. up to day 15 (SR), b) during the weaning period from day 15 to 30 (WR), c) throughout 30 days post partum (SWR) and d) during adulthood, i. e. from day 60-75 of life (AR). In comparison with the ad libitum fed controls (C), the lactating mothers and the pups of the food-restricted groups were allowed free access to food for only two hours daily. In experimental groups this restriction was then changed to an ad libitum regime. On day 90 food intake was evaluated daily in five 20 min lasting sessions after 23 h of fasting in group-housed and single-housed rats exposed to their home as well as to their experimental environment. e significantly decreased body weight found on day 30 and 90 in females coming from litters of restrictedly fed mothers, as compared with those fed ad libitum, showed that these animals were considerably undernourished. Appetitive motivation increased in those groups of females that had been exposed to a restricted feeding regime during their infant period but remained unaffected in females restrictedly fed during their adult age. In comparison with the ad libitum fed controls and AR groups, significantly increased mean food intake was observed in all postnatally underfed groups (P < 0.001). e greatest inclination to hyperphagia and qualitative changes in feeding behaviour were observed in SWR females whose feeding regime was restricted for the longest time, i. e. during the suckling and the weaning period, as compared to groups with shorter food restriction. ese animals showed hyperphagia even in the new environment regardless whether the whole group or only one female was tested. Our results reveal a) a determinant influence of the feeding regime of the animals at early age (41%) while environmental and social factors represent only about 17% and 4%, respectively and that b) changes in feeding habits in adult female rats may significantly depend on the length of postnatal undernutrition.

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Neonatal undernutrition and self-grooming development in the rat: Long-term effects

Cited by 16 publications

References 25 publications

Dendritic Branching of Claustral Neurons in Neonatally Undernourished Rats

Dendritic Branching of Claustral Neurons in Neonatally Undernourished Rats

Effects of Neonatal Undernutrition and Binaural Ear Occlusion on Neuronal Development of the Superior Olivary Complex of Rats

Effect of early nutritional experience on the feeding behaviour of adult female rats

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