Neonatal thyroid screening in a mild iodine deficiency endemic area in Iran

Najafi, Mohammad; Khodaee, Gholam Hossein; Bahari, Mohammad; Sabahi, Masoumeh; Farsi, Mostafa Mazlom; Kiani, Fatomeh

doi:10.4103/0019-5359.39614

Cited by 15 publications

(11 citation statements)

References 12 publications

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“…The frequency of CH as well as transient hypothyroidism was relatively high in our study. Our data confirm the findings of previous studies regarding the high prevalence of hypothyroidism in Iran (15-18). For example, a meta-analysis study by Veisani et al (18) revealed that the overall incidence of CH in Iran is 2/1000 of live births.…”

Section: Discussionsupporting

confidence: 92%

Permanent and Transient Congenital Hypothyroidism in Hamadan West Province of Iran

Razavi

Mohammadi

2016

Int J Endocrinol Metab

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BackgroundPrimary congenital hypothyroidism (CH) is the most common treatable cause of mental retardation and can be classified into permanent and transient types. The purpose of this study was to determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Hamadan, West province of Iran.MethodsThe study population included all cases with primary congenital hypothyroidism, which were confirmed by thyroid function tests (TSH levels ≥ 10 mIU/L). All these patients had been followed up at the outpatient pediatric endocrine clinic of Besat hospital (Hamadan, Iran) for a period of time between May 2006 and March 2013. Biochemical findings at diagnosis and detailed medical records were collected. Patients were considered as permanent hypothyroidism if their TSH level was 10 (mIU/l) during 6 - 12 months of treatment. Also three years old patients with TSH level > 10 mU/L during one or three months after discontinuation of levothyroxine treatment were considered as permanent hypothyroidism.ResultsA total of 164 children (49.9% male and 50.6% female) diagnosed with CH completed the study. Female/male ratio was 1.02/1. The incidence of CH was about 1/1250 in Hamadan, West province of Iran. Of the 164 patients, 105 cases (64 %) were diagnosed as permanent CH and other 59 cases (36%) were proven to have transient hypothyroidism. Female to male ratio was 1.14 in patients suffering from permanent CH and 0.8 in patients with transient CH. The initial TSH level was found to be significantly higher in cases with permanent CH compared to the patients with transient CH (P = 0.001). Mean TSH level during the first year of treatment was higher in permanent CH cases compared to transient cases (P = 0.001). Children with transient CH had a lower TSH serum level during the three years of treatment (P = 0.000). A significant statistical difference was not found between the genders and permanent or transient CH (P = 0.352). Co-occurring congenital anomalies and birth order were significantly different between two groups (P = 0.028 and P = 0.024, respectively).ConclusionsOur regional follow-up data showed that about 40% of newborns with primary CH had transient thyroid dysfunction. Our results further clarify our previous research by providing evidences on the incidence rate of CH. The incidence rates of CH as well as transient type of CH in our region were higher than those reported by other studies which have been conducted in other regions of the world. The initial TSH level was the strongest predictor of treatment cessation. Given the high incidence of transient CH in our region, further studies are needed to confirm the etiology and to provide considerable insight into preventive and/or the treatment strategies.

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Section: Discussionsupporting

confidence: 92%

Permanent and Transient Congenital Hypothyroidism in Hamadan West Province of Iran

Razavi

Mohammadi

2016

Int J Endocrinol Metab

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“…The first screening for CH in in Markazi Province was performed in 2006. According to the national screening program, the prevalence of CH in Iran is higher than global statistics and different prevalence figures are reported in different provinces (5,6,9,10,11). …”

Section: Introductionmentioning

confidence: 95%

Epidemiology of Congenital Hypothyroidism in Markazi Province, Iran

Dorreh¹,

Chaijan²,

Javaheri³

et al. 2014

Jcrpe

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Objective: The aim of this study was to investigate the epidemiology of congenital hypothyroidism (CH) among newborns in Markazi Province, Iran.Methods: This cross-sectional study was conducted from 2006 to 2012. Blood samples were taken between 3 to 5 days after birth from the heel. Thyroid stimulating hormone (TSH) was tested using the enzyme-linked immunosorbent assay method and was employed as the screening test. Newborns with abnormal screening results (TSH >5 mIU/L) were re-examined. The data were analyzed using SPSS.Results: A total of 127 112 infants were screened. Of these, 51.2% were male and 48.8% were female. The coverage rate of the screening program was 100%. Of 6102 recalled subjects (re-call rate 4.8%), 414 cases with CH were detected, yielding a CH prevalence of 1:307 (female:male ratio 1:0.95). The prevalence of permanent and transient CH was 1:581 and 1:628, respectively.Conclusion: This study reveals that the prevalence of CH is higher compared to worldwide levels. Comprehensive and complementary studies for recognizing related risk factors should be a priority for health system research in this province.

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“…Since several screened cases were found as hypothyroidism thus, the cutoff point was diminished to 5 mU/l. On this protocol, the neonates with the primary dried blood TSH more than 5 mU/l were recalled for measurements of the serum TSH, T4, and T3 and clinical examinations (16). However, the protocol improved the newborn screening program but the recall rate was high (3.6%).…”

Section: Neonatal Screening Programmentioning

confidence: 99%