Neonatal Thymectomy Increases the Incidence of Spontaneous and Methylcholanthrene-Enhanced Thyroiditis in Rats

Silverman, David A.; Rose, Noel R.

doi:10.1126/science.184.4133.162

Cited by 55 publications

(13 citation statements)

References 14 publications

(13 reference statements)

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“…These results added to the growing body of evidence that there was a regulatory population of T cells produced in the thymus that were capable of suppressing the adoptively transferred disease. Very similar results were found using the BUF rat and OS chicken models of thyroiditis (25,26). The nature and role of a suppressor population of thymic derived T cells had a long and somewhat troubled history and are still a topic of vigorous discussion (27).…”

Section: Non-h-2 Genessupporting

confidence: 81%

The genetics of autoimmune thyroiditis: The first decade

Rose

2011

Journal of Autoimmunity

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Most of our current understanding of the genetic predisposition to autoimmune disease can be traced to experiments performed in the decade from 1971 to 1981. Chella David was a key contributor to this research. Many of these early steps came from studies of experimental autoimmune thyroiditis. This model has been especially valuable because essentially the same disease can occur spontaneously in selected strains of animals or can be induced by deliberate immunization. From a genetic point of view, the disease has been investigated in three different species: mice, rats and chickens. The same antigen, thyroglobulin, initiates the disease in all three species. Among the main discoveries were the relationship of autoimmune disease to the major histocompatibility complex (MHC), the interplay of different subregions within the MHC in promoting or retarding development of disease, the differing roles of MHC class II and MHC I class genes in induction and effector phases, respectively, and the cumulative effect of non-MHC genes, each of which represents a small addition to overall susceptibility. Other experiments revealed that genetic differences in thyroglobulin allotypes influence susceptibility to thyroiditis. Thyroid glands differed in different strains in vulnerability to passive transfer of antibody. The first evidence of modulatory genes on the sex-related X chromosome emerged. All of these genetic findings were concurrently translated to the human disease, Hashimoto’s thyroiditis, where thyroglobulin is also the initiating antigen.

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Section: Non-h-2 Genessupporting

confidence: 81%

The genetics of autoimmune thyroiditis: The first decade

Rose

2011

Journal of Autoimmunity

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“…Speculative as they may be, deliberations on this issue need to take into account the role of T reg cells in EAT [reviewed in (77)], which are likely, as mentioned above, to recognize noniodinated Tg determinants intrathymically and in the periphery. T reg cells have been implicated in early studies of spontaneous development of thyroiditis in thymectomized rodents (78)(79)(80), and their suppressive function has been recently linked to the CD4 þ CD25 þ subset (81)(82)(83). Our group has shown that i.v.…”

Section: Tg-specific Abs As Regulators Of Tg Recognition By T Cellsmentioning

confidence: 98%

Recognition of Thyroglobulin by T Cells: The Role of Iodine

Carayanniotis

2007

Thyroid

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Among known autoantigens, thyroglobulin (Tg) is unique in its capacity to store iodine, an element provided in our daily diet. Evolutionary pressure has sculpted Tg into a large molecular scaffolding to allow organification of iodide and its incorporation into thyroid hormones. The increase in molecular size and the posttranslational modification by iodine had to exact immunological consequences. Over the last 15 years, numerous Tg peptides-targets of thyroiditogenic T cells-have been mapped, raising questions regarding the mechanisms that maintain or abrogate immune tolerance against this large autoantigen. This review summarizes the work in this area and discusses the role iodine may play in these processes.

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“…299 It has been suggested that iodine increases the auto-antigenic potency of thyroglobulin in this susceptible strain. 295 Immunization of rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant results in thyroiditis in Buffalo but not Lewis rats. 301 Studies of these animals have confirmed the key role of CD4 1 T cells in the induction and suppression of experimental autoimmune thyroiditis.…”

Section: Laboratory Animalsmentioning

confidence: 99%

Endocrine Glands

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

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Neonatal Thymectomy Increases the Incidence of Spontaneous and Methylcholanthrene-Enhanced Thyroiditis in Rats

Cited by 55 publications

References 14 publications

The genetics of autoimmune thyroiditis: The first decade

The genetics of autoimmune thyroiditis: The first decade

Recognition of Thyroglobulin by T Cells: The Role of Iodine

Endocrine Glands

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