Neonatal thrombocytopenia: causes and management

Roberts, Irene; Murray, Neil A

doi:10.1136/fn.88.5.f359

Cited by 174 publications

(178 citation statements)

References 75 publications

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“…17 Burrows and colleagues found that in hypertensive mothers, preterm birth was the major risk factor for neonatal thrombocytopenia. Term infants exposed to maternal hypertension had the same incidence of thrombocytopenia as the control population.…”

Section: Discussionmentioning

confidence: 99%

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

et al. 2008

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“…IUGR and pre-eclampsia are known to be associated with thrombocytopenia. 8,9 The etiology of thrombocytopenia with both of these conditions may be related to placental insufficiency and/or fetal hypoxia. 9 Our data confirm these known associations showing a decrease in platelet number in IUGR infants and those infants born to mothers with pre-eclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 The etiology of thrombocytopenia with both of these conditions may be related to placental insufficiency and/or fetal hypoxia. 9 Our data confirm these known associations showing a decrease in platelet number in IUGR infants and those infants born to mothers with pre-eclampsia. The reductions in platelet mass with IUGR and pre-eclampsia were due to lower platelet counts, because the MPV was not decreased with either condition.…”

Section: Discussionmentioning

confidence: 99%

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Mackley

Christensen

et al. 2011

J Perinatol

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“…1 The overall prevalence of thrombocytopenia in neonates ranges from 1 to 5% and is reported to be much higher in neonates admitted to neonatal intensive care units, ranging from 22 to 35%. 1 It is more common among extremely low birth weight neonates, preterm or sick neonates in NICUs. In contrast, only 2% of the normal neonates are thrombocytopenic at birth with Severe thrombocytopenia (platelet count < 50,000/L) occurring in less than 3/1000 term infants.…”

Section: Introductionmentioning

confidence: 99%

Study of risk factors of neonatal thrombocytopenia

Tirupathi

Swarnkar

Vagha

2016

Int J Contemp Pediatr

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Background: Neonatal thrombocytopenia (platelet count < 1.5 lac/µl) is the commonest haematological abnormality encountered in neonatal intensive care unit (NICU). Thrombocytopenia if not detected can result in devastating complications. Determining the risk factors of thrombocytopenia enables us to prevent the inevitable and irreversible complications. The present study highlights the pattern, severity and risk factors of neonatal thrombocytopenia in our hospital.Methods: Prospective observational study was conducted on 200 neonates with thrombocytopenia admitted in NICU of our hospital. Maternal and neonatal risk factors were recorded. Neonates were grouped based on the severity of thrombocytopenia. The risk factors were compared with severity of thrombocytopenia.Results: 200 neonates with thrombocytopenia were divided into three groups based on severity of thrombocytopenia. 81% of babies had moderate to severe thrombocytopenia. The most common maternal predisposing factors were pregnancy induced hypertension (PIH), premature rupture of membranes (PROM) and anemia.62.5% babies were low birth weight babies and they had severe thrombocytopenia. 56% babies had late onset neonatal thrombocytopenia and 44% had early onset thrombocytopenia. The most common neonatal risk factors were sepsis in 48.5% babies and birth asphyxia in 20% babies.Conclusions: The severity of neonatal thrombocytopenia in our NICU was moderate to severe type. PIH, PROM and anemia were the commonest maternal risk factors. Preterm and low birth weight babies had severe thrombocytopenia. Sepsis and birth asphyxia were the commonest neonatal risk factors. Birth asphyxia was associated with early onset neonatal thrombocytopenia and sepsis was associated with late onset thrombocytopenia. Severe thrombocytopenia can be used as a prognostic indicator in sick neonates.

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Neonatal thrombocytopenia: causes and management

Cited by 174 publications

References 75 publications

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Study of risk factors of neonatal thrombocytopenia

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