Neonatal thrombocytopenia associated with maternal pregnancy induced hypertension

Bhat, Y. Ramesh; Cherian, Carol Sara

doi:10.1007/s12098-008-0110-x

Cited by 22 publications

(6 citation statements)

References 9 publications

(11 reference statements)

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“…Pritchard et al have shown that in neonates of mothers with preE, the incidence of neonatal thrombocytopenia varies widely from 9.2 to 36%. 8 16 In another study, the incidence of thrombocytopenia associated with this disorder has been estimated at 1 per 100 live births, and it is more likely to occur in preterm and low-birth-weight infants. 13 Furthermore, several studies have also shown a prevalence of thrombocytopenia in 1 to 5% of all newborns born to mothers with preE; however, the prevalence varies depending upon the population studied.…”

Section: Incidence and Prevalence Of Neonatal Thrombocytopeniamentioning

confidence: 99%

“…Backes et al have demonstrated that preE affects the fetus and newborn in several ways. 7 8 These effects include an increased risk of fetal demise or stillbirth; increased neonatal mortality and morbidity; IUGR; premature birth; hematological abnormalities, such as thrombocytopenia, polycythemia, and neutropenia; necrotizing enterocolitis (NEC); bronchopulmonary dysplasia; adverse neurodevelopmental outcomes and fetal origin of adult disease states. 7 8 The purpose of this article is to review neonatal thrombocytopenia as a consequence of preE, its pathogenesis, and management.…”

Section: Consequences Of Preeclampsia In the Newbornmentioning

confidence: 99%

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Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia

Kalagiri

Choudhury

Carder

et al. 2015

AJP Rep

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Introduction Preeclampsia (preE) is pregnancy-induced hypertension affecting a significant proportion of pregnant women worldwide and can cause detrimental effects in the mother and newborn. Some of the effects in the newborn include neonatal thrombocytopenia. Pertaining specifically to neonatal thrombocytopenia, several questions remain unanswered. Discussion According to the current literature, neonatal thrombocytopenia due to maternal preE is highly prevalent in the general population and the incidence is reported to be around 30% worldwide. This review gives an insight into the syndrome and summarizes the possible pathological mechanisms, the diagnostic approach, complications, and therapeutic interventions of neonatal thrombocytopenia. It also identifies the involvement of other cell lines, apart from platelets in the newborns. Furthermore, we suggest a future prospective study to investigate the pathogenesis of preE and plan a study involving animal models to come up with a possible therapeutic intervention to prevent preE and its various consequences in neonates.

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Section: Incidence and Prevalence Of Neonatal Thrombocytopeniamentioning

confidence: 99%

Section: Consequences Of Preeclampsia In the Newbornmentioning

confidence: 99%

Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia

Kalagiri

Choudhury

Carder

et al. 2015

AJP Rep

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“…The risk of thrombocytopenia is significantly increased in neonates with body weight <1500 g than those with body weight >1500 g 23,28 . Our findings corroborate this finding.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Zhou

et al. 2023

Preprint

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Background Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension would likewise impact the incidence of early-onset neonatal thrombocytopenia. Therefore, we conducted a retrospective study to validate our hypothesis. Methods In this study, we included 538 neonates, comprising 318 and 220 neonates born to healthy mothers and those with pregnancy-induced hypertension (PIH), respectively. The minimum platelet count within 72 hours of birth was recorded for these neonates. The incidence of early-onset thrombocytopenia in neonates in relation to maternal gestational hypertension, preeclampsia, and health status was evaluated. The differences between the three groups were analyzed using the chi-square test. Logistic regression analysis was conducted to assess the relationship between maternal gestational hypertension or preeclampsia and the risk of early-onset neonatal thrombocytopenia. Results The incidence of early-onset thrombocytopenia in neonates born to mothers with preeclampsia was significantly higher than in those born to mothers with gestational hypertension or healthy mothers. Significant differences were observed between the three groups (30.0% vs. 13.3% vs. 7.9%, P < 0.001). Maternal gestational hypertension (OR=2.55, 95% CI 1.10–5.91, P < 0.05) and preeclampsia (OR=2.41, 95% CI 1.18–4.93, P <0.05) increased the risk of early-onset neonatal thrombocytopenia when compared to healthy mothers. Conclusions Our findings suggest that maternal gestational hypertension increases the occurrence of early-onset neonatal thrombocytopenia. Therefore, we recommend conducting platelet count screening in the early stages for newborns of mothers with gestational hypertension.

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“…Thrombocytopenia was also higher in the study group, but not statistically significantly (42.9% vs. 40.3%). Different incidences of thrombocytopenia have been reported, up to as much as 36% by Bhat et al [24].…”

Section: Discussionmentioning

confidence: 99%

Neonatal outcomes of preterm infants born to preeclamptic mothers

Duramaz¹,

Bilgin²,

Salihoğlu³

et al. 2017

Marmara Medical Journal

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IntroductionHypertensive diseases are one of the most frequent medical complications in pregnancy, and the main reasons of maternal, fetal, and neonatal morbidity and mortality [1]. Preeclampsia is a systemic disease of pregnancy with hypertension, proteinuria, and edema, which affects the fetus because of utero-placental deficiency, that leads to growth retardation [2]. Preeclampsia is reported in approximately 2-8% of pregnancies. The incidence may vary according to race, region, and country [3]. The etiology of preeclampsia is still uncertain. Diabetes mellitus, kidney disease, obesity, ABSTRACTObjectives: Preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality. The aim of this study was to determine neonatal outcomes of premature infants born to preeclamptic mothers.Patients and Methods: Preterm infants ≤36 gestational age who were born to preeclamptic mothers and normotensive mothers were included in this study. Infant's data including demographic characteristics, neonatal morbidities and mortalities were evaluated retrospectively.Results: Hundred and forty infants born to preeclamptic mothers (study group) and 144 infants born to normotensive mothers (control group) were included. No statistical difference was found between mean gestational age, birth weight, Apgar scores at 1 and 5 minutes, and in terms of sex ratio. Cesarean delivery, small gestational age and neutropenia rates were found significantly higher in the study group. Other neonatal morbidities such as necrotising enterocolitis and sepsis were also found higher in the study group but it was not statistically significant. Hospitalization and mortality rates were similar in both groups.Conclusions: Preeclampsia was associated with increased cesarean delivery, small gestational age and neutropenia. There were no significant differences between other morbidities and mortality of two groups. We think that prematurity is the main risk factor of morbidity and mortality regardless of concomitant.

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Neonatal thrombocytopenia associated with maternal pregnancy induced hypertension

Abstract: Premature and low birth weight neonates born to mothers with pregnancy induced hypertension would require scrutiny for thrombocytopenia during early neonatal period.

Cited by 22 publications

References 9 publications

Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia

Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Neonatal outcomes of preterm infants born to preeclamptic mothers

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