Neonatal thrombocytopenia and its relation to maternal disease

Abstract

Introduction: Platelets first appea r in the human fetus at five weeks post-concep tion, and increase in number during fetal life, reaching n ormal adult values by 22 weeks of gestation. Objectives: The aim of this work t o screen neonatal thrombocytopenia, its causes and its relation to maternal diseases. Patients and methods: This prospective study was carried out in the Neonatal Intensive Care Unit (NICU) at the Obstetrics and Gynec ology Department of MINIA University Hospital from the beginning of March 2017 till the June 2017. T his study was carried out on 150 neonates w o were admitted to the NICU and met the inclusion crit eria for enrollment into this study including 45 (30%)male neonates and 105(70%) female neonates ,th eir age ranged from (28 week-38 week) Who delivered to mothers which has maternal disease durin g pregnancy e.g (Diabetes , Pre mature rup ture of membrane , TORCH , preeclampsia, placental ab normalities). Results: The study included 150 newborn children, 102 (68%) of whom were premature infants and 48(32%) of them were term neonates & (70%)of them were females and(30%) of them were males& mode of delivery was cesarean section in(82.7%)and vaginal delivery was (17.3%). In our study there were significant increase in maternal diseases in preterm neonates when compared with full term with p.value (0.004, 0.0002, 0.001, 0.001,0.001) for each of them respectively ,while HTN diseases were common in full term neonates (p.0.004). There was significant correlation between birth weight and maternal illness that thrombocytopenia most common among ELBW. Conclusion: placental insuffici ency and perinatal asphyxia are relate d to early onset thrombocytopenia.