Neonatal syringocystadenoma papilliferum: A case report

Abstract

BACKGROUND Syringocystadenoma papilliferum (SCAP) represents a rare, noncancerous adnexal tumor predominantly presenting at birth or in early childhood. CASE SUMMARY In this study, a 35-day-old girl was admitted to Kunming Children’s Hospital in October 2019 due to a lesion in the right frontotemporal region since birth. The surface of the lesion was bright red, granular, and papillary and easily bled upon touch, with about 1.5 cm × 4 cm in size. A subcutaneous mass was felt at the base of the lesion, with a size of about 3 cm × 5 cm. Dermatoscopy showed that the skin lesion was lobular and crumby. The lesion center was reddish or white, while the edges were white or yellowish band-like. There were polymorphic vascular structures and white radial streaks in the lesion, with some vascular clusters scattered. Pathological examination showed papilloma-like hyperplasia of the epidermis, with the epidermis partly sinking into the dermis to form several cystic depressions. Combining clinical and histopathological features, the child was diagnosed with SCAP. Follow-up is ongoing, and surgical resection will be performed. CONCLUSION This was a special clinical manifestation of SCAP, which complements the clinical manifestations of the disease and provides new insights for the diagnosis and differentiation of neonatal skin tumors.

Syringocystadenoma papilliferum presenting as an isolated scalp nodule

“…SCAP is a benign adnexal hamartoma showing apocrine or eccrine differentiation, with varied clinical and dermoscopic features and definitive histopathological findings 1. Half of the cases arise at birth or in early childhood and 15%–30% arise during puberty 2…”

Cytomorphological features of syringocystadenoma papilliferum mimicking pilomatricoma at a rare location and in an unusual age group: A cytological diagnostic challenge

“…Syringocystadenoma papilliferum (SCAP), also referred to as syringocystadenomatosus papilliferus, is a rare, benign cutaneous adnexal tumor, presenting most commonly at birth or during childhood and adolescence 1 . It usually presents as a solitary papular or a nodular lesion as a smooth hairless plaque in the head and neck region with a predilection for female gender 2 …”