Neonatal Survival After Prolonged Preterm Premature Rupture of Membranes Before 24 Weeks of Gestation

Brumbaugh, Jane E.; Colaizy, Tarah T.; Nuangchamnong, Nina; O'Brien, Emily; Fleener, Diedre; Rijhsinghani, Asha; Klein, Jonathan M.

doi:10.1097/aog.0000000000000511

Cited by 33 publications

(24 citation statements)

References 27 publications

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“…Although the role of amniotic fluid as a predictor of mortality has recently been questioned [9,18], our data, including a larger number of women, and in line with previous reports [1,4,12,30,31], suggest that the presence of a lower LVP at admission is associated with a significantly higher rate of perinatal mortality.…”

Section: Discussionsupporting

confidence: 80%

“…Thus, Hadi et al [19] evaluated the role of the mean of amniotic fluid volume throughout pregnancy showing a higher neonatal survival to discharge in women with an adequate amniotic fluid volume until delivery. However, Brumbaugh et al [9] recently observed that neonatal survival to discharge in prolonged EPPROM was not related to the evolution of the LVP along time. They defined prolonged EPPROM as latency to delivery of ≥7 days.…”

mentioning

confidence: 99%

“…However, the definition of prolonged oligohydramnios remains unclear [2,4,9,10,15,16,18]. A precise definition of prolonged oligohydramnios would help obstetricians and parents in the decision-making process regarding the perinatal mortality.…”

mentioning

confidence: 99%

“…They defined prolonged EPPROM as latency to delivery of ≥7 days. According to Brumbaugh et al [9], the main determinant of neonatal survival to discharge was gestational age at delivery. Likewise, Hunter et al [18] analyzed the amount of amniotic fluid as a predictor of neonatal survival to discharge and found it did not predict neonatal survival.…”

mentioning

confidence: 99%

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Contribution of Amniotic Fluid along Gestation to the Prediction of Perinatal Mortality in Women with Early Preterm Premature Rupture of Membranes

et al. 2017

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Introduction: To evaluate the largest vertical pocket (LVP) of amniotic fluid as a time-dependent factor to predict perinatal mortality in women with early preterm premature rupture of membranes (EPPROM). Material and Methods: Observational cohort studyof singleton pregnancies with EPPROM <24 weeks. Termination of pregnancy (TOP) was considered if the LVP was <2 cm at 7 days. The maternal and neonatal characteristics of ongoing pregnancies were recorded. Prediction of perinatal mortality was estimated based on the influence of the LVP as a time-dependent factor after adjustment for maternal age, prior invasive procedure, and gestational age at EPPROM. Results: Of 104 women, 39 requested TOP. Neonatal survival to discharge was 40%, increasing to 74% if pregnancies achieved 24 weeks. LVP at admission <1 cm, latency to delivery, and gestational age at delivery were independent predictors of perinatal mortality. When evaluating the LVP at different time points of gestation, the highest perinatal mortality risk was established at 2 weeks (odds ratio 14.67, p < 0.001) after membrane rupture, being 5.75 (p = 0.05) the week after and 10.93 (p = 0.037) beyond 2 weeks of EPPROM. Discussion: When LVP measurement, gestational age at EPPROM, maternal age, and prior invasive procedure were considered, we found that the worst prognosis related to perinatal mortality was at 2 weeks after EPPROM.

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Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Contribution of Amniotic Fluid along Gestation to the Prediction of Perinatal Mortality in Women with Early Preterm Premature Rupture of Membranes

et al. 2017

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“…However, in some recent studies, survival rates can be as high as 70 to 90%. (1,(5)(6)(7) In addition to the increased risk of mortality, these neonates are also at risk of several morbidities including hypoxemic respiratory failure, sepsis, limb contractures, potential neonatal asphyxia due to cord compression or placental abruption in addition to the risks of (extreme) prematurity. Hypoxemic respiratory failure is attributable to pulmonary hypoplasia and arterial pulmonary hypertension.…”

Section: Introductionmentioning

confidence: 99%

Impact of gestational age at PPROM on the short-term outcome of children born after extreme and prolonged preterm prelabor rupture of membranes in an experienced care center

Hocq¹,

B²,

Bernard³

et al. 2017

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Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Eleje

Ezugwu

Ezebialu

et al. 2018

Intl J Gynecology & Obste

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Objective To compare AmnioQuick Duo+ versus the placental α‐microglobulin‐1 (PAMG‐1) test for diagnosis of prolonged premature rupture of membranes (PROM). Methods A multicenter prospective cohort study included women with suspected PROM at six tertiary institutions in southern Nigeria between January 1 and December 31, 2015. The inclusion criteria were features of PROM lasting at least 24 hours and a pregnancy duration of more than 24 weeks. AmnioQuick Duo+ (Biosynex, Strasbourg, France) and PAMG‐1 (AmniSure International, Boston, USA) tests were used to diagnose PROM, which was confirmed after delivery by any two of the following criteria: delivery within 48 hours to 7 days, chorioamnionitis, membranes perceptibly ruptured at delivery, and adverse perinatal outcomes considerably associated with prolonged PROM. Results Of 100 women assessed for eligibility, 99 were included. Sensitivity, specificity, and accuracy were, respectively, 97.3%, 100%, and 95.9% for AmnioQuick Duo+, and 93.2%, 100%, and 90.4% for PAMG‐1. The differences were not significant and the diagnostic discordant rate between the two tests was 3.1%. In equivocal cases (i.e., negative pooling test result), AmnioQuick Duo+ and PAMG‐1 performed equally (diagnostic accuracy, 100% vs 97.7%; P>0.99). Conclusion For diagnosis of PROM, AmnioQuick Duo+ was found to be non‐inferior and comparable in accuracy to the PAMG‐1 test, with a diagnostic discordance rate of 3.1%.

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Neonatal Survival After Prolonged Preterm Premature Rupture of Membranes Before 24 Weeks of Gestation

Abstract: With antenatal steroid exposure and aggressive pulmonary management, survival to discharge after prolonged preterm PROM was 90%. Pulmonary morbidities were common. Of note, the data were limited to women who remained pregnant 1 week or longer after rupture of membranes.

Cited by 33 publications

References 27 publications

Contribution of Amniotic Fluid along Gestation to the Prediction of Perinatal Mortality in Women with Early Preterm Premature Rupture of Membranes

Contribution of Amniotic Fluid along Gestation to the Prediction of Perinatal Mortality in Women with Early Preterm Premature Rupture of Membranes

Impact of gestational age at PPROM on the short-term outcome of children born after extreme and prolonged preterm prelabor rupture of membranes in an experienced care center

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

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