Neonatal skin barrier

Stamatas, Georgios N.

doi:10.1111/bjd.14946

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…Diffuse reflectance spectroscopy (DRS) has been used for a number of biomedical applications including epithelial tissue characterization, brain study, breast cancer detection and surgical margin assessment, skin pigmentation research etc. [20][21][22][23][24][25][26][27][28] DRS has been preferred technique for its application in blood perfusion and tissue oxygenation studies within ultraviolet-visible wavelength range and researchers have extended these spectroscopic measurements range up to NIR (400-1600 nm) to include absorption from lipid and water chromophores. [29,30] It has been reported that extended NIR wavelength region measurement renders a better discrimination between benign and tumor sites as well as accurate estimation of chromophores present in the tissue.…”

Section: Introductionmentioning

confidence: 99%

Quantitative in vivo detection of adipose tissue browning using diffuse reflectance spectroscopy in near‐infrared II window

Dev

Dinish

Chakraborty

et al. 2018

Journal of Biophotonics

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White adipose tissue (WAT) and brown adipose tissue (BAT) biologically function in an opposite way in energy metabolism. BAT induces energy consumption by heat production while WAT mainly stores energy in the form of triglycerides. Recent progress in the conversion of WAT cells to "beige" or "brown-like" adipocytes in animals, having functional similarity to BAT, spurred a great interest in developing the next-generation therapeutics in the field of metabolic disorders. Though magnetic resonance imaging and positron emission tomography could detect classical BAT and WAT in animals and humans, it is of a great challenge in detecting the "browning" process in vivo. Here, to the best of our knowledge, for the first time, we present a simple, cost-effective, label-free fiber optic-based diffuse reflectance spectroscopy measurement in the near infrared II window (~1050-1400 nm) for the quantitative detection of browning in a mouse model in vivo. We could successfully quantify the browning of WAT in a mouse model by estimating the lipid fraction, which serves as an endogenous marker. Lipid fraction exhibited a gradual decrease from WAT to BAT with beige exhibiting an intermediate value. in vivo browning process was also confirmed with standard molecular and biochemical assays.

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