Neonatal Sex Assignment in Disorders of Sex Development: A Philosophical Introspection

Raveenthiran, V

doi:10.21699/jns.v6i3.604

Cited by 14 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thoughtful respectful care is critical for the management of infants, children, adolescents, and their families to ensure positive and meaningful quality of life. Goals for individuals with DSDs include psychosocial well-being, sexual satisfaction, and fertility options [73].…”

Section: Discussionmentioning

confidence: 99%

Disorders of sex development

Witchel

2018

Best Practice & Research Clinical Obstetrics & Gynaecol

133

View full text Add to dashboard Cite

Normal sex development depends on the precise spatio-temporal sequence and coordination of mutually antagonistic activating and repressing factors. These factors regulate the commitment of the unipotential gonad into the binary pathways governing normal sex development. Typically, the presence of the SRY gene on the Y chromosome triggers the cascade of molecular events that lead to male sex development. Disorders of sex development comprise a heterogeneous group of congenital conditions associated with atypical development of internal and external genitalia. These disorders are generally attributed to deviations from the typical progression of sex development. Disorders of sex development can be classified into several categories including chromosomal, gonadal, and anatomic abnormalities. Genetic tools such as microarray analyses and next-generation sequencing techniques have identified novel genetic variants among patients with disorders of sexual development. Most importantly, patient management needs to be individualized, especially for decisions related to sex of rearing, surgical interventions, hormone treatment, and potential for fertility preservation.

show abstract

Section: Discussionmentioning

confidence: 99%

Disorders of sex development

Witchel

2018

Best Practice & Research Clinical Obstetrics & Gynaecol

133

View full text Add to dashboard Cite

show abstract

“…Genitalia thus is granted “the power of synecdochic representation” with respect to sex, sexuality, and gender (Karkazis, 2008). However, there are many more “biological markers” of sex than the genital attributions used to determine SAB (Raveenthiran, 2017). Sex dimorphism relates to numerous factors: external genitalia, internal genitalia, hormone composition, and chromosomal composition, and does not necessarily align with all of these other facets of sex dimorphism.…”

Section: The Entanglement Of Gender With Other Social Effects On Lang...mentioning

confidence: 99%

Perceiving gender while perceiving language: Integrating psycholinguistics and gender theory

Tripp

Munson

2021

WIRES Cognitive Science

View full text Add to dashboard Cite

There is a substantial body of literature showing that men and women speak differently and that these differences are endemic to the speech signal. However, the psycholinguistic mechanisms underlying the integration of social category perception and language are still poorly understood. Speaker attributes such as emotional state, age, sex, and race have often been treated in the literature as dissociable, but perceptual systems for social categories demonstrably rely on interdependent cognitive processes. We introduce a diversity science framework for evaluating the existing literature on gender and speech perception, arguing that differences in beliefs about gender may be defined as differences in beliefs about differences. Treating individual, group, and societal level contrasts in ideological patterns as phenomenologically distinctive, we enumerate six ideological arenas which define claims about gender and examine the literature for treatment of these issues. We argue that both participants and investigators predictably show evidence of differences in ideological attitudes toward the normative definition of persons. The influence of social knowledge on linguistic perception therefore occurs in the context of predictable variation in both attention and inattention to people and the distinguishing features which mark them salient as kinds. We link experiences of visibility, invisibility, and hypervisibility with ideological variation regarding the significance of physiological, linguistic, and social features, concluding that gender ideologies are implicated both in linguistic processing and in social judgments of value between groups. We conclude with a summary of the key gaps in the current literature and recommendations for best practices studies that may use in future investigations of socially meaningful variation in speech perception. This article is categorized under: Linguistics > Language in Mind and Brain Psychology > Language Linguistics > Language Acquisition Psychology > Perception and Psychophysics

show abstract

“…Konvencionalni tretman osoba sa KAH obuhvata medikamentoznu supstituciju hormona kao i hirurške metode rekonstrukcije genitalija. Iako se pretpostavlja da će ovakve intervencije u ranom periodu dovesti do poboljšanja psihosocijalnog blagostanja osobe i boljeg kvaliteta života, postoje studije koje pokazuju da ovakve metode potencijalno uzrokuju emocionalne probleme kod ovakvih pacijenata [9,10]. Iako postoje jasni dokazi o izloženosti ovih pacijenata raznim psihijatrijskim stanjima, psihološka podrška često ne ulazi u rutinski tretman.…”

Section: Uvodunclassified

Congenital adrenal hyperplasia associated with mental disorders: A case report

Grujičić¹,

Maslak²,

Stupar³

et al. 2020

Psihijatrija danas

View full text Add to dashboard Cite

Introduction: Congenital adrenal hyperplasia (CAH) is an inherited autosomal recessive disorder characterized by a defect in the synthesis of steroid hormones of the adrenal cortex. This defect results in elevated serum androgen levels. Androgens have been shown to have a significant effect on the developing brain during prenatal and postnatal period, which can lead to impaired neurocognitive functioning and contribute to the development of psychiatric disorders. The aim: In this paper, we will present a patient with CAH who developed serious psychiatric problems during adolescence. The aim of this case report is to discuss a possible connection between these two conditions and to consider possible diagnostic and therapeutic interventions. Case report: The patient was diagnosed with the classic form of CAH at birth. After months of corticosteroid substitution therapy, the patient was surgically treated at 7 months of age with vaginoplasty and clitoroplasty. The patient developed serious psychiatric problems from the depressive-anxiety spectrum in the early adolescent period, followed by impaired impulse control and aggression. This report illustrates the diagnostic and therapeutic interventions conducted at the Clinical Department for Children and Adolescents of the Institute of Mental Health. Conclusion: Given the abundant evidence on the impact of CAH on cognitive ability and psychosocial functioning, it is necessary to develop and implement complementary multidisciplinary diagnostic and therapeutic interventions in these patients. Such interventions would aim to prevent the onset of psychiatric comorbidities and consequently improve the quality of life and functionality of these patients.

show abstract

Neonatal Sex Assignment in Disorders of Sex Development: A Philosophical Introspection

Cited by 14 publications

References 57 publications

Disorders of sex development

Disorders of sex development

Perceiving gender while perceiving language: Integrating psycholinguistics and gender theory

Congenital adrenal hyperplasia associated with mental disorders: A case report

Contact Info

Product

Resources

About