Neonatal septicemia

Das, Amitabha; Chatterjee, B. D.; Khatua, Soumen; Ghose, B.; Saha, Anil

doi:10.1007/bf02749537

Cited by 100 publications

(102 citation statements)

References 18 publications

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“…The culture positive rate was 54.1% which is comparable to culture positive rate of 43% observed by Chackoo et al, 59.8% by Khatua et al 1,16 This difference in positivity of blood culture is because blood culture positivity depends on many factors like specimen collection, blood volume and the number and timing of blood culture.…”

Section: Discussionsupporting

confidence: 53%

“…1,14,15 In present study, as per Table 1, lethargy was most common clinical feature in current study (76.1%) followed by refusal to feed (75.2%), respiratory distress (66.1%), hypothermia (38.5%), hyperthermia (28.4%), abdominal distension (11.9%), jaundice (10.1%), convulsions (10.1%), apnea (7.3%), irritability (3.7%), vomiting (2.8%), sclerema (1.8%) and diarrhea (1.8%). Kathua et al 16 reported refusal to feed as common clinical presentation (92%) followed by lethargy (74%), diarrhea (74%), abdominal distension (60.1%), hypothermia (46.8%), jaundice (38%), vomiting (30.4%), hyperthermia (24.8%), respiratory distress (24%), sclerema (17.4%), apnea (13%) and convulsions (10.8%). 16 Malik et al reported refusal to feed as the commonest clinical feature (77%) followed by hyperthermia (60%), lethargy (51%), hypothermia (46.6%), abdominal distension (35%) and respiratory distress (26%).…”

Section: Discussionmentioning

confidence: 99%

“…Kathua et al 16 reported refusal to feed as common clinical presentation (92%) followed by lethargy (74%), diarrhea (74%), abdominal distension (60.1%), hypothermia (46.8%), jaundice (38%), vomiting (30.4%), hyperthermia (24.8%), respiratory distress (24%), sclerema (17.4%), apnea (13%) and convulsions (10.8%). 16 Malik et al reported refusal to feed as the commonest clinical feature (77%) followed by hyperthermia (60%), lethargy (51%), hypothermia (46.6%), abdominal distension (35%) and respiratory distress (26%). 17 The differences in the percentage of different clinical features at the time of admission could be because of different population groups in various studies.…”

Section: Discussionmentioning

confidence: 99%

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Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

Khurana

Malik

Narang

et al. 2017

Int J Contemp Pediatr

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Background: Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms of infection in the first month of life. Neonatal sepsis refers to infection occuring within the neonatal period i.e. first 28 days of life for a term baby and up to 4 weeks beyond the expected date of delivery in a preterm baby. Neonatal sepsis is one of the major cause of neonatal morbidity and mortality.Methods: The present study is a prospective observational study conducted in the neonatal intensive care unit (NICU) of Sri Guru Ram Das Institute of Medical Sciences and Research (SGRDIMSAR), Sri Amritsar over a period of one year from January 2015 to January 2016. Aim of the study is to know the incidence of neonatal sepsis, to study bacteriology of neonatal septicemia and to evaluate the risk factors associated with mortality in neonatal sepsis in our hospital.Results: During the study period (January 2015 to January 2016), 727 neonates were admitted in NICU of SGRDIMSAR, Sri Amritsar. Out of them, 109 neonates were diagnosed as having septicemia. Incidence of neonatal sepsis in our hospital in this study is 149.9/1000 neonatal admissions. 59 (54.1%) neonates had positive blood culture. Out of 109 septic neonates, 50 died and 59 survived. Mortality observed in the present study is 45.9%.Conclusions: It is concluded from present study that the main factors associated with neonatal mortality are low birth weight, prematurity, positive blood culture, neutropenia and prolonged prothrombin time. Some of the risk factors like low birth weight and prematurity are preventable by proper antenatal check ups and measures can be taken for safe and hygienic delivery. Babies with risk factors should be monitored closely for early detection of sepsis and the neonates with sepsis having abnormal laboratory parameters should be subjected to appropriate therapeutic intervention in order to decrease the mortality.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

Khurana

Malik

Narang

et al. 2017

Int J Contemp Pediatr

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“…Khatua situated on the X chromosome. 19 Presence of one X chromosome in male infants thus confers less immunological protection compared to female counterpart.…”

Section: Sex Wise Distribution Of the Casesmentioning

confidence: 99%

Clinical and bacteriological study of neonatal septicaemia in a tertiary care hospital

Khante

Raut

2017

Int J Res Med Sci

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Background: Neonatal sepsis is a clinical syndrome of bacteraemia characterized by systemic signs and symptoms in the first month of life. It is the leading causes of neonatal mortality and morbidity. Early diagnosis and treatment with appropriate antibiotics is important to improve the prognosis of neonatal sepsis. Our objectives were to study the organisms causing neonatal septicaemia, associated risk factors, to correlate CRP with blood culture and to study mortality rate in neonatal septicaemia.Methods: The study of 2 years included clinically suspected cases of neonatal septicaemia admitted in NICU. 566 blood samples were collected, processed and isolates were identified. Maternal and neonatal risk factors were studied. CRP test was done by slide agglutination test.Results: Blood culture was positive in 205 (36.22%) cases. Among the culture positive cases, 128 (62.44%) were males and 77 (37.56%) females with male to female ratio of 1.66:1. Early onset sepsis was present in 137 (66.83%) and late onset sepsis in 68 (33.17%) cases. 107 (52.20%) were low birth weight babies. The most common neonatal risk factor was prematurity 75 (36.58%) and maternal risk factor was prolonged rupture of membrane 65 (31.71%). gram negative bacilli 144 (70.24%) were found to be common cause of sepsis than gram positive cocci 61 (29.76%), Klebsiella pneumoniae 54 (26.34%) being most common pathogen. Out of 566, CRP test was positive in 244 (43.10%) cases. Mortality rate was 23.41%.Conclusions: Neonatal septicaemia is a life-threatening emergency. The study of etiological profile and CRP test plays a significant role.

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17] However, many of these studies were hospital-based in large urban centers, with a high likelihood for inclusion of nosocomial infections and reflecting an urban population rather than the rural environment where the majority of neonatal deaths occur. Although group B Streptococcus has been a common cause of neonatal sepsis in industrialized countries, 18 its role in developing countries is less certain.…”

Section: Introductionmentioning

confidence: 99%

Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines)

et al. 2007

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Objective: To determine the bacterial etiology, clinical presentation and risk factors for outcome of serious community-acquired infections in young infants.Study Design: Infants younger than 60 days, admitted for severe pneumonia or suspected sepsis/meningitis were prospectively evaluated using complete blood count, blood culture, chest radiograph, cerebrospinal fluid (CSF) culture in suspected meningitis. w 2 or Fisher's exact test and stepwise logistic regression were used for analysis.Results: Thirty-four of 767 enrolled infants had a positive blood or CSF culture. Gram-negative bacteria were more frequent than Gram positive: overall (P ¼ 0.004), in those below 7 days of age (P ¼ 0.002) and among home deliveries (P ¼ 0.012). Case fatality rates were higher among infants below 1 week old (OR 4.14, P<0.001), those with dense (OR 2.92, P<0.001) or diffuse radiographic infiltrates (OR 2.79, P ¼ 0.003).Conclusions: Gram-negative enteric bacteria are the predominant causes of community-acquired infections in Filipino infants below 2 months old. Age below 7 days and radiographic pneumonia predicted death.

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Neonatal septicemia

Cited by 100 publications

References 18 publications

Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

Clinical and bacteriological study of neonatal septicaemia in a tertiary care hospital

Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines)

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