Neonatal Sepsis-Like Syndrome with Human Parechovirus Type 4

Abstract

A 24-day-old boy was admitted to our hospital with fever. Three days after admission, his condition worsened, and he presented with reticular cyanosis. He was diagnosed with sepsis-like syndrome. Human parechovirus type 4 was detected in serum and stool samples by reverse transcription polymerase chain reaction and sequencing. His condition improved after intravenous gamma-globulin treatment. There are few reports of sepsis-like syndrome caused by human parechovirus type 4, and its clinical features and treatment have not been established, but immunoglobulin therapy may be effective in severe cases.