Neonatal sepsis in very low birthweight infants at the university hospital of the West Indies

Trotman, H; Bell, Y.

doi:10.1590/s0043-31442006000300007

Cited by 19 publications

(29 citation statements)

References 17 publications

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“…The most common pathogen identified in our study was Klebsiella pneumoniae (6/13) which is similar to that reported by others. [3][4][5] However, group B streptococci and E. coli, which are common pathogens, causing early neonatal sepsis in the western countries were not seen in this study. Other organisms isolated were coagulase negative Staphylococcus (3/13), Pseudomonas spp (2/13), Micrococci spp (1/13) and A fecalis (1/13).…”

Section: Dear Editormentioning

confidence: 72%

“…Significant risk factors for EONS identified in this study by uni-variate analysis were pre-term and low birth weight babies, gravida less than or equal to two, maternal fever and PROM for more than 16 hours while multivariate analysis showed only pre-term delivery and PROM for more than16 hours to be significant risk factors which is similar to the observations of other investigators. [1,5] An interesting observation was that out of five mothers who had fever at the time of delivery, four had babies with a positive blood culture. Likewise, out of eight babies who had a positive CRP, six had a positive blood culture.…”

Section: Dear Editormentioning

confidence: 99%

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Etiology and risk factors for early onset neonatal sepsis

Ananthakrishnan¹,

Gunasekaran²

2009

Indian J Med Microbiol

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The microbiological pattern of early onset neonatal sepsis (EONS) is different from late onset sepsis and is associated with several peri-natal risk factors. In view of the high mortality associated with this condition septic screening is carried out and empirical treatment with antibiotics started in the presence of two or more of these risk factors, resulting in a large number of babies receiving unnecessary antibiotics.[1] In order to identify these risk factors and the infective organisms so that empirical treatment with antibiotics could be more focused in our hospital, (a private sector teaching hospital providing level III care) a small case control study was carried out.The study group comprised of 32 consecutive babies with clinical features of sepsis and less than seven days of age and 60 randomly selected well babies discharged without any clinical evidence of sepsis during the same period formed the controls. Blood culture was sent for all babies and C reactive protein for 25 babies suspected to have sepsis. Other relevant investigations were done as needed.The incidence of EONS in the study period was 34/1000. A positive blood culture was obtained in 13 babies with sepsis (40.6%) which is similar to that reported by Kaushik and Rao [2][3] but lower than that observed by Tallur.[4] C reactive protein was positive (more than 8mg/dl) in 32% (8/25). The most common pathogen identified in our study was Klebsiella pneumoniae (6/13) which is similar to that reported by others.[3-5] However, group B streptococci and E. coli, which are common pathogens, causing early neonatal sepsis in the western countries were not seen in this study. Other organisms isolated were coagulase negative Staphylococcus (3/13), Pseudomonas spp (2/13), Micrococci spp (1/13) and A fecalis (1/13). The parameters considered for analysis of risk factors were antenatal care, birth order, birth weight, gestational age, gender, maternal fever, premature rupture of membranes (PROM), mode of delivery, birth asphyxia and meconium-stained liquor. Significant risk factors for EONS identified in this study by uni-variate analysis were pre-term and low birth weight babies, gravida less than or equal to two, maternal fever and PROM for more than 16 hours while multivariate analysis showed only pre-term delivery and PROM for more than16 hours to be significant risk factors which is similar to the observations of other investigators. [1,5] An interesting observation was that out of five mothers who had fever at the time of delivery, four had babies with a positive blood culture. Likewise, out of eight babies who had a positive CRP, six had a positive blood culture. However, this association between maternal fever, positive CRP and positive blood cultures is not statistically significant and needs a larger study to substantiate the observation.In conclusion, significant peri-natal risk factors for EONS, identified in this study, were prematurity and rupture of membranes more than 16 hours and the most common infective organism was Klebsiella pneumo...

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Section: Dear Editormentioning

confidence: 72%

Section: Dear Editormentioning

confidence: 99%

Etiology and risk factors for early onset neonatal sepsis

Ananthakrishnan¹,

Gunasekaran²

2009

Indian J Med Microbiol

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“…Escherichia coli can cause infections of a variety of extraintestinal sites such as the urinary tract, meninges, and bloodstream (3,5,8,(10)(11)(12)21). Diagnosis of most extraintestinal E. coli (ExPEC) infections requires bacterial culture, requiring 1 to 2 days of incubation, and subsequent confirmatory testing (6,17).…”

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confidence: 99%

Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Common Strains of Escherichia coli

et al. 2008

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“…So, 71.05% of VLBW neonate survived after management in this hospital. The survival rate of VLBW infants worldwide ranges between 43% in developing countries such as Jamaica 19 to more than 90% in developed countries, such as 21 .…”

Section: Discussionmentioning

confidence: 99%

“…There are many reports of factors affecting early survival of VLBW infants. The survival rate of VLBW infants worldwide ranges between 43% in developing countries such as Jamaica 14 to more than 90% in developed countries, such as the Netherlands 15 , in India it is 63% 16 .…”

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confidence: 99%

Outcome of Very Low Birth Weight Neonates in a Tertiary Level Hospital Outside Capital of Bangladesh: A Study in Faridpur Medical College Hospital

Hasan¹,

Biswas²,

Saha³

et al. 2016

Faridpur Med Coll J

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Abstract:Very low birth weight (VLBW) is an important cause of infant mortality and still a challenge for achieving Millennium Development Goal (MDG) in Bangladesh. Our study was to see the risk factors and its outcome of VLBW neonates in a tertiary level Faridpur Medical College Hospital (FMCH), outside capital Dhaka. This prospective cross sectional study was conducted in neonatal Unit of pediatric department in FMCH. All neonates who were admitted here had been selected and we find out the very low birth weight neonates for our study purpose. All anthropometric measurements were taken by us in our department. We took all the informations about neonates within our study period of six months (November 2013 to April 2014) through a prescribed protocol. Total 1126 neonates admitted within our study period of 6 months. Among 1126 neonates 76 of them were VLBW. Among 76 VLBW neonates 38 (50%) were male and 38 (50%) were female, but 22 of them were expired, which was 28.94% of total VLBW neonates. Most expired on month of March which was 38.46%. Among expired VLBW neonates 10 (45.45%) of them were male and 12 (54.55%) of them were female. Total 48 (63.15%) mothers of VLBW neonates delivered at hospital of them Caesarean section occurs in 40 (52.63%) mothers of VLBW neonates and normal vaginal delivery (NVD) occurs in 36 cases (47.37%). Home delivery occurs in mothers of 28 VLBW neonates. Among them 15 (53.57%) were done by traditional birth attendance (TBA), 8 (28.57%) by local dai and 5 (17.86%) by relatives of the family of VLBW neonates. We found mothers of 41 (53.95%) VLBW neonates had premature rupture of membrane (PROM), 8 (10.53%) had eclampsia, 4 (5.26%) had leaking membrane and 4 (5.26%) had history of accident. Maternal age of VLBW neonates are more common between 18 to 24 years of age that was 53.95% (41 in number) but 27 mothers (35.52%) were below 18 years of age . We found in our study that the survival rate of VLBW neonates in our institute is not like developed countries but it is better than many developing countries around the world.

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Neonatal sepsis in very low birthweight infants at the university hospital of the West Indies

Cited by 19 publications

References 17 publications

Etiology and risk factors for early onset neonatal sepsis

Etiology and risk factors for early onset neonatal sepsis

Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Common Strains of Escherichia coli

Outcome of Very Low Birth Weight Neonates in a Tertiary Level Hospital Outside Capital of Bangladesh: A Study in Faridpur Medical College Hospital

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