Neonatal Sepsis in A Tertiary Care Hospital: Evaluation of Causative Agents and Antimicrobial Susceptibilities

Nahar, Begum Sharifun; Afroza, Syeda; Roy, Sunirmol; Nahar, Nurun; Kundu, Tarok Nath

doi:10.3329/bjch.v37i1.15346

Cited by 9 publications

(12 citation statements)

References 7 publications

(2 reference statements)

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“…A lower isolation rate was also reported by Hiral et al 23 in Gujrat, India where they found 9.92% E.coli. Isolation rate of Klebsiella pneumoniae in the present study was 6.06%, which was comparable to some other studies 7,17,19,24 . A higher isolation rates was also observed in other studies 6,19,25 .…”

Section: Resultssupporting

confidence: 91%

“…Pseudomonas aeruginosa was isolated at the rate of 3.03% which was comparable to other studies 6,[24][25][26] . A higher isolation rates was also observed by others 7,22 . This extreme rate of variation may be due to geographical variations as well as variation in gestational age, birth weight, child health care facilities, maternal nutrition and maternal vaginal flora, perinatal care and hygienic conditions of mother.…”

Section: Resultssupporting

confidence: 85%

“…In this study, out of 116 blood samples, 33(28.4%) had yielded growth of both Gram positive and Gram negative bacteria which was nearly similar with the study of Shrestha et al 13 In this study Gram positive bacteria were more frequent isolates (60.6%) than the Gram negative bacteria (39.4%) which is consistent with the study of Shrestha et al 13 in Nepal where Gram positive bacterial isolates were 56.8% and Gram negative was 44.2%. In another study done by Nahar et al 7 in Bangladesh show the dominance of Gram negative bacteria was 78% in neonatal sepsis and Gram positive bacterial isolates was 22%.…”

Section: Discussionmentioning

confidence: 90%

“…In Bangladesh, a few studies have reported on causative agents of neonatal septicaemia and their antibiotic sensitivity pattern [6][7][8] . The spectrum of organisms that causes neonatal sepsis changes over times and varies from region to region.…”

mentioning

confidence: 99%

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Neonatal Septicemia: Isolation, Identification and Antibiotic Sensitivity Pattern of Bacteria in a Tertiary Hospital in Bangladesh

Afrin¹,

Siddique

Ahmed³

et al. 2017

Faridpur Med Coll J

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Abstract:A cross sectional descriptive study was done to find out the causative organisms and their antibiotic sensitivities in the Department of Microbiology in collaboration with the Department of Paediatrics, Rajshahi Medical College Hospital (RMCH), Rajshahi during the period of July 2014 to June 2015. A total of 116 blood samples were taken aseptically from patients who were suspected of neonatal septicemia. Blood was then inoculated in Brain heart infusion broth. Bacterial isolation, identification and antimicrobial susceptibility testing were done by standard microbiological methods. Among 116 cases, 33(28.4%) were found to be culture positive. The most commonly isolated causative agents of neonatal septicemia were Staphylococcus aureus 17(51.5%) followed by Escherichia coli 10(30.3%), Streptococcus pneumoniae 03(9.09%), Klebsiella pneumoniae 02(6.06%) and Pseudomonas aeruginosa 01(3.03%). In general, all the Gram positive and Gram negative isolates were highly sensitive to meropenem, amikacin, gentamicin and ciprofloxacin. Gram positive bacteria were found to be particularly sensitive to vancomycin. They were moderately sensitive to ceftazidime followed in amoxicillin but were totally resistant to ampicillin. This study revealed that Staphylococcus aureus and E.coli are predominant causative organisms in neonatal septicemia and these are highly sensitive to meropenem, amikacin, gentamicin and ciprofloxacin.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 85%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

See 2 more Smart Citations

Neonatal Septicemia: Isolation, Identification and Antibiotic Sensitivity Pattern of Bacteria in a Tertiary Hospital in Bangladesh

Afrin¹,

Siddique

Ahmed³

et al. 2017

Faridpur Med Coll J

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“…Findings from this study did not correspond to a study done in a Neonatal Intensive Care Unit (NICU) in Bangladesh, where they identified gram negative organisms (78%) to be the most common pathogen of neonatal sepsis. 19 However, in a similar study in Ghana in a tertiary hospital, gram positive organisms had a preponderance over gram negative organisms; similar to findings in this study except that their study had a larger sample size. 17 However, a similar study in a NICU in China, found that gram positive organisms were responsible for a greater proportion of early onset sepsis (83.3%) and late onset sepsis (70%) as compared to gram negative organisms 19 which corroborates the findings of this study.…”

Section: Discussionsupporting

confidence: 79%

Bacteriological Profile of Neonatal Sepsis in a Neonatal Intensive Care Unit of a Tertiary Care Hospital of Eastern Nepal

Yadav¹,

Giri²

2019

J Coll Med Sci-Nepal

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Background: Neonatal sepsis is a common and serious problem of neonates who are admitted for intensive care. It is a leading cause of neonatal morbidity and mortality worldwide. The objective of the study was to detect the common causative microorganisms of neonatal sepsis and their antibiotic susceptibility patterns in NICU of Nobel Medical College Teaching Hospital (NMCTH). Methods: This was a cross-sectional study conducted in a 17- bedded teaching and referral NICU of NMCTH from March to August, 2018. All neonates of clinical sepsis were enrolled in the study, blood cultures taken and were followed up till final outcome, which was discharge or death, irrespective of culture report. Descriptive statistics including percentages and frequencies was used.complications. Results: Among the 55 neonates with diagnosis of clinical sepsis, 13(23.6%) had shown bacteria in the culture. The predominant organisms were Staphylococcus aureus and Klebsiella pneumoniae and most of them were resistant to Ampicillin and Amikacin. Conclusions: The culture positivity rate among the neonates with clinical sepsis in the study was 23.6%. Pathogens isolated were resistant to the first line drugs for management of neonatal sepsis. Hence, the need for a review of first line drug for empirical treatment of neonatal sepsis.

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Cross Sectional Study on a Spectrum of Bacterial Pathogens under Actions of Infection Control in Different Clinical Specimens of ICU Patients of Sajer General Hospital in Saudi Arabia, and Their Antibiotic Sensitivity Pattern

Alenezi¹,

El-Tahtawi²,

Makhlouf³

2021

jemds

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BACKGROUND The intensive care unit (ICU) is a special department of the hospital and health care setting that provides intensive nursing care and care to patients with the most severe and life-threatening illnesses and injuries that require accurate, continuous monitoring and support from specialist, medication, and equipment in order to maintain normal bodily functions. Nosocomial infections are one of the leading causes of mortality in hospitalised patients especially the critically ill patients in the intensive care unit. The purpose of the present study was isolation, identification, and detection of the antibiotic sensitivity pattern of pathogenic bacteria isolated from different clinical specimens of ICU patients under the effect of infection control in Sajer General Hospital in Saudi Arabia. METHODS In this cross-sectional study conducted from January 2020 to April 2020, 200 clinical samples, 40 blood, 45 urine, 50 tracheal aspirate, 30 post-surgical Caesarean section wound swabs, 20 central venous catheters and 15 pus swabs were collected from patients hospitalised in ICUs of Sajer General Hospital. Antibiotic sensitivity testing was performed with the diffusion-disk method for several antibiotics. RESULTS The rate of nosocomial infection among ICU patients due to Gram-negative bacteria is significantly higher than that recorded by Gram-positive bacteria (78.75 %, 21.25 %, respectively). The majority of frequent bacteria isolated from all clinical specimens were Klebsielleae pneumoniae 20 (25 %) followed by Pseudomonas aeruginosa 18 (22.5 %), Acinetobacter baumannii 15 (18.75 %), Escherichia coli 10 (12.50 %), Staphylococcus aureus 9 (11.25 %), Streptococcus pyogenes 6 (7.50 %) and enterococcus spp. 2 (2.50 %). K. pneumoniae, P. aeruginosa and E. coli achieved high sensitivity to imipenem and meropenem (100 %). A. baumannii showed high sensitivity to meropenem (100 %) and imipenem (93.33 %). Staph. aureus, Streptococcus pyogenes and enterococcus species showed high sensitivity to vancomycin (100 %). CONCLUSIONS The nosocomial infection is a major cause of mortality and morbidity in hospitals. The role of nursing care in the prevention of nosocomial infection has proven vital due to the emergence and spreading of different pathogenic bacteria. Close interactions between health care providers can save many more lives. KEY WORDS Intensive Care Units, Antibiotics Sensitivity Pattern, Nursing Infection Control

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Neonatal Sepsis in A Tertiary Care Hospital: Evaluation of Causative Agents and Antimicrobial Susceptibilities

Cited by 9 publications

References 7 publications

Neonatal Septicemia: Isolation, Identification and Antibiotic Sensitivity Pattern of Bacteria in a Tertiary Hospital in Bangladesh

Neonatal Septicemia: Isolation, Identification and Antibiotic Sensitivity Pattern of Bacteria in a Tertiary Hospital in Bangladesh

Bacteriological Profile of Neonatal Sepsis in a Neonatal Intensive Care Unit of a Tertiary Care Hospital of Eastern Nepal

Cross Sectional Study on a Spectrum of Bacterial Pathogens under Actions of Infection Control in Different Clinical Specimens of ICU Patients of Sajer General Hospital in Saudi Arabia, and Their Antibiotic Sensitivity Pattern

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