Neonatal Sepsis Due to Bacillus subtilis

Lampropoulos, Panagiotis; Gkentzi, Despoina; Tzifas, Sotiris; Dimitriou, Gabriel

doi:10.7759/cureus.17692

Cited by 7 publications

(6 citation statements)

References 8 publications

(8 reference statements)

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“…inaquosorum . It is commonly found in the environment and in the human gut and is generally considered non-hazardous to human health ( 6 ). Bacteremia can be difficult to distinguish from infection and contamination.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis Caused by Bacillus subtilis var. natto

et al. 2023

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A 67-year-old woman with a 2-day history of a fever, headache and disturbed consciousness was admitted to our hospital. Bacillus subtilis was isolated from both the cerebrospinal fluid and blood. She was cured by the administration of vancomycin. Next-generation sequencing identified the strain as B. subtilis var. natto, the same strain found in natto, which this patient ate daily. We suspected that some of the B. subtilis that caused the infection may have actually been B. subtilis var. natto.

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Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis Caused by Bacillus subtilis var. natto

et al. 2023

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“…Bacillus subtilis is a common cause of infections and is susceptible to several existing medicines (Fang et al 2014). Meningitis, neonatal sepsis, pneumonia, and wound infection by B. subtilis (Lampropoulos et al 2021;Tokano et al 2023). It occurs most frequently in patients with underlying diseases or immunocompromised (Kato et al 2022).…”

Section: Pseudomonas Aeruginosa Staphylococcus Aureus Andmentioning

confidence: 99%

Antibacterial activity of sea hare (Dolabella auricularia) egg string extracts against potentially pathogenic bacteria

LIGUEZ,

TABUGO

2024

Biodiversitas

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Abstract. Liguez CGO, Tabugo SR. 2023. Antibacterial activity of sea hare (Dolabella auricularia) egg string extracts against potentially pathogenic bacteria. Biodiversitas 24: 6675-6683. Pharmaceutical industries now recognize the vast variety of ocean organisms, each possessing distinct biological characteristics. Sea hares, for example, are marine organisms that use bioactive chemicals to defend against predators, including their eggs. To explore the potential antibacterial properties of sea hare species (Dolabella auricularia) found in Pujada Bay, Philippines, egg strings were collected and extracted using hexane and methanol solvents. The antibacterial activity of each fraction was then determined through Minimum Inhibitory Concentration (MIC) testing against four potentially pathogenic bacteria, two gram-positive strains (Staphylococcus aureus, Bacillus subtilis) and two gram-negative strains (Escherichia coli, Pseudomonas aeruginosa). The broth microdilution method was employed to assess the antibacterial activity of Dolabella auricularia egg strings. The results revealed the MIC values for the four bacterial strains. The hexane extracts of both extract 1 and extract 2 exhibited a MIC of 0. 23 and 0.33 mg/mL and a MIC of 0.52 and 0.125 mg/mL against P. aeruginosa, respectively. The methanolic extracts (1 and 2) displayed a MIC of 1.46 and 2.83 mg/mL against E. coli and an even more potent MIC of 1.33 and 0.79 mg/mL against P. aeruginosa. In the case of B. subtilis, the hexane extracts (1 and 2) had a MIC of 1.5 and 0.54 mg/mL, while the methanolic extracts (1 and 2) exhibited a MIC of 1.17 mg/mL and 0.83 mg/mL. Lastly, against S. aureus, hexane extracts (1 and 2) suppressed the growth with a MIC of 0.77 mg/mL and 0.25 mg/mL, respectively, while both methanolic extracts (1 and 2) demonstrated a MIC of 3.33 mg/mL. These findings showcase the promising antibacterial activity of Dolabella auricularia egg string extracts and highlight their potential for further investigation and development in the pharmaceutical field.

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“…Classification at the strain level is necessary since even species that are considered generally harmless can harbor strains with pathogenic potential. For example, although the majority of Bacillus subtilis strains exhibit minimal virulence, they can also be causative pathogens ( Lampropoulos et al, 2021 ). Since patients in hospitals are particularly vulnerable and many times immunocompromised, their safety must be considered before opting for novel sanitizing regimes.…”

Section: Addressing Gaps and Future Perspectives Of Microbial Cleaningmentioning

confidence: 99%

A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings

Fijan,

Kürti,

Rozman

et al. 2024

Front. Microbiol.

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The global rise in antimicrobial resistance (AMR) poses a significant public health threat, especially in healthcare settings, where controlling the spread of antimicrobial genes is crucial. While person-to-person transmission remains the primary route for healthcare-associated infections (HAIs), hospital surfaces serve as key reservoirs for antimicrobial-resistant microorganisms. Regular cleaning and disinfection of these surfaces are essential. Microbial-based products for sanitizing hospital surfaces have emerged as promising tools to combat HAIs and AMR. However, a review of 32 publications found inconsistencies and potential risks. A total of 15 publications included hospital-based trials, while the rest were either in vitro or in situ assays, reviews, book chapters, or commentaries. In most of the hospital-based studies, specific strains of applied microorganisms were not identified, and the term “probiotic” was inaccurately used. These products mainly featured spores from Bacillus and Priestia genera, which was mainly hypothesized to work through competitive exclusion. Most hospital-based studies have shown that the application of microbial-based products resulted in a significant reduction in pathogens on surfaces, thereby contributing to a decrease in the incidence of healthcare-associated infections (HAIs). Further research is however needed to understand the effectiveness, mechanisms of action, and safety of microbial-based sanitizing agents. Strain-level identification is crucial for safety assessments, yet many reviewed products lacked this information. Consequently, there is a need for rigorous safety evaluations within existing regulatory frameworks to ensure the efficacy and safety of microbial-based cleaning products in healthcare settings.

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Neonatal Sepsis Due to Bacillus subtilis

Cited by 7 publications

References 8 publications

Bacterial Meningitis Caused by <i>Bacillus subtilis</i> var. <i>natto</i>

Bacterial Meningitis Caused by <i>Bacillus subtilis</i> var. <i>natto</i>

Antibacterial activity of sea hare (Dolabella auricularia) egg string extracts against potentially pathogenic bacteria

A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings

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