Neonatal SEP – Back to bedside with basic science

Vanhatalo, Sampsa; Lauronen, Leena

doi:10.1016/j.siny.2006.07.009

Cited by 66 publications

(52 citation statements)

References 65 publications

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“…Most previous preterm SEP studies have focused on the first cortical response as a predictor of sensorimotor outcome because it reflects the integrity of the somatosensory pathways from the periphery to the SI (21,22). In the current study, as in a previous MEG study (18), SI response was seen in every infant, thus having no predictive value in our study population consisting of ELGA infants with relatively mild neuroimaging abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

et al. 2013

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“…The best described feature in the development of SEPs in premature babies is the shortening of the first cortical response N1 (for review, see Vanhatalo and Lauronen, 2006), which corresponds to a unilateral fronto-occipital potential gradient created by a tangential dipole in the postcentral gyrus (Karniski, 1992). Developmental changes of later components were also described in premature babies; however, the underlying cortical events are difficult to infer because of the paucity of topographical SEP data, the lack of intracortical recordings, and the gyrification process that could modify the orientation of cortical currents.…”

Section: Discussionmentioning

confidence: 99%

Functional Development of Large-Scale Sensorimotor Cortical Networks in the Brain

Quairiaux

Mégevand

Kiss

et al. 2011

Journal of Neuroscience

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Large-scale neuronal networks integrating several cortical areas mediate the complex functions of the brain such as sensorimotor integration. Little is known about the functional development of these networks and the maturational processes by which distant networks become functionally connected. We addressed this question in the postnatal rat sensorimotor system. Using epicranial multielectrode grids that span most of the cortical surface and intracortical electrodes, we show that sensory evoked cortical responses continuously maturate throughout the first 3 weeks with the strongest developmental changes occurring in a very short time around postnatal day 13 (P13). Before P13, whisker stimulation evokes slow, initially surface-negative activity restricted mostly to the lateral parietal area of the contralateral hemisphere. In a narrow time window of ϳ48 h around P13, a new early, sharp surface-positive component emerges that coincides with subsequent propagation of activity to sensory and motor areas of both hemispheres. Our data show that this new component developing at the end of the second week corresponds principally to functional maturation of the supragranular cortical layers and appears to be crucial for the functional associations in the large-scale sensorimotor cortical network. It goes along with the onset of whisking behavior, as well as major synaptic and functional changes within the S1 cortex that are known to develop during this period.

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“…The waveform components of SERs have been studied in several in vivo and in vitro animal models (7). Current literature suggests that the slow component requires a concerted action of the subplate and cortex, and its presence reflects the maturational stage where thalamocortical fibers are just about to establish their afferent cortical connections.…”

Section: Discussionmentioning

confidence: 99%

“…In essence, the conventional SEP paradigms are just modifications from adult SEP recordings, which assume that cortical responses are rapid, constant in shape, and they do not show a notable fatigue to fast repeating stimuli. Because of the already known variability, time scales, and other characteristics of the sensory systems during early development, the current SEP parameters (stimulation frequency, filters, time windows, and averaging) are likely to effectively hamper if not preclude observation of the brain responses characteristic of human preterm brain (7).…”

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confidence: 99%

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

Vanhatalo

Jousmäki²,

Andersson

et al. 2009

Pediatr Res

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This study was set out to develop and describe a novel, simple, and safe method for routine bedside testing of somatosensory system in very early preterm infants. We recorded electroencephalogram (EEG) activity after tactile stimulation of hand (palm) and foot (sole) by a soft hairbrush stimulator in extremely low birth weight infants (n ϭ 10; GA, 24 -28, recording at conceptional age 30 -32 wk) and compared with the raw EEG responses to those seen by one-or two-channel brain monitors. In every subject, single tactile stimuli produced prominent (100 -350 V) somatosensory evoked responses (SERs) that were readily identified in the ongoing EEG signal. The maximal SER was in the contralateral hemisphere at around the corresponding somatosensory representation areas. Conventional EEG filtering did significantly reduce the SERs, but they could still be identified in the routine brain monitor setting widely available in NICUs. The method described here is directly applicable to assessment of integrity of somatosensory system in the early preterm period. It needs minimal training and requires an EEG system or a brain monitor device that is available in most units. Thus, the technique is likely to open a novel window to neurologic assessment of these babies. (Pediatr Res 66: 710-713, 2009)

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Neonatal SEP – Back to bedside with basic science

Cited by 66 publications

References 65 publications

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

Functional Development of Large-Scale Sensorimotor Cortical Networks in the Brain

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

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