Neonatal secretion of gastrin and glucagon

Rogers, Ian Munro; Davidson, D C; Lawrence, Joyce; Ardill, Joy; Buchanan, K. D.

doi:10.1136/adc.49.10.796

Cited by 81 publications

(50 citation statements)

References 18 publications

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“…Our results do show that both arterial and venous gastrin levels are higher after spontaneous labour, which confirms our previous observation on the influence of oxytocin infusion on cord gastrin levels (Rogers et al, 1974).…”

Section: Discussionsupporting

confidence: 93%

Neonatal gastric hyperacidity: further analysis of oxytocin effect.

Davidson¹,

Rogers²,

Ardill³

et al. 1975

Archives of Disease in Childhood

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Section: Discussionsupporting

confidence: 93%

Neonatal gastric hyperacidity: further analysis of oxytocin effect.

Davidson¹,

Rogers²,

Ardill³

et al. 1975

Archives of Disease in Childhood

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“…Indeed one study showed that mean basal acid output was at its lowest on the tenth day of life, which is about the time when PYY levels are highest (22). Hypergastrinemia has been reported at this stage and is probably a physiologically important event because gastrin is trophic to the antral mucosa (22)(23)(24). High PYY levels may suppress the acid hypersecretion that would otherwise occur.…”

Section: Methodsmentioning

confidence: 99%

Elevated Plasma Peptide YY in Human Neonates and Infants

et al. 1986

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ABSTRACT. Plasma concentrations of peptide YY ( P W ) were measured in cord blood and at 6, 12, and 18 days of postnatal life in 24 healthy preterm neonates, from cord blood of eight full-term neonates, and from peripheral blood of 13 infants 9 months old. Concentrations were high in cord blood (73 f 9 pmol/liter versus adult fasting 10.4 f 1.3, p < 0.001) and rose postnatally in the premature infants to 399 f 48 pmol/liter at 6 days, 489 f 42 at 12 days, and fell to 414 f 43 at 18 days. Plasma PYY concentrations were much lower in infants 9 months old (32 f 3 pmol/liter), suggesting that the postnatal surge of plasma PYY is a feature of early adaptation to extrauterine life. Gel permeation chromatograms revealed that the major circulating form of PYY in the neonate eluted in a position identical to that of the pure 36 amino acid peptide. There was, however, evidence of two larger molecular forms that may be precursor molecules. Because P W is a peptide that exhibits potent effects on gastrointestinal secretion and motility in humans, these observations suggest that this candidate gut hormone may be important in the adaptation to enteral nutrition in the neonate. (Pediatr Res 20: 1225-1227 Abbreviation PYY, peptide tyrosine tyrosine or peptide W PYY is a recently discovered candidate gut hormone that has a broad spectrum of biological actions (1-5). PYY is produced by endocrine cells in the distal bowel, and plasma concentrations rise in response to the ingestion of food (3, 6, 7). Infusion studies in adult humans, at doses producing increments of plasma PYY concentrations within the physiological range, have revealed potent inhibitory effects on gastric secretion and emptying and also a delay of mouth-cecum transit (8,9). Recently we observed that circulating PYY concentrations in young healthy pigs were greater than those of adult humans and rats (6, 10). Although this difference may have been due to species it raised the possibility that PYY plays a particular role in the developing animal (7). The aim of the present study was to measure plasma PYY concentrations at birth and in early life to evaluate whether this peptide could be important in the adaptation of the human neonate to extrauterine life. PATIENTS AND METHODSHealthy infants born before 34 wk gestation entered the study, which was approved by the hospital ethics committee. Informed parental consent was also obtained; 24 infants were studied. The mothers of 15 of these (birth weight 1620 _+ 67 g, gestation 32 _+ 1 wk, mean _+ SE) wanted to establish lactation, and their infants were fed only with regular boluses of breast milk by nasogastric feeding tube. The nine infants of mothers not wishing to breastfeed (birth weight 1564 _+ 1 17 g, gestation 3 1 _+ 1 wk, mean _+ SE) were given regular boluses of an adapted milk formula (Nenatal, Nutricia International BV) in daily volumes as recommended by the manufacturer. Both groups of infants tolerated their feeds well and gained weight as expected. None developed diarrhea or any other complication, and ...

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“…Rogers et al (6) reported that oxytocin use during labor caused a lower cord gastrin level than when infants were spontaneously delivered. We could not confirm this observation.…”

Section: Euler and Walshmentioning

confidence: 99%

Human Newborn Hypergastrinemia: An Investigation of Prenatal and Perinatal Factors and Their Effects on Gastrin

1978

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SummaryBecause gastrin is a potent gastric acid stimulus and gastric acid secretion begins soon after birth, we measured umbilical cord serum gastrins. We also examined multiple factors present during the gestation, labor, delivery, and immediate postpartum period to see what effect, if any, these might have on the serum gastrins.Two groups were studied: 217 newborn infants and 802 adults without Zollinger-Ellison syndrome. The newborns' median serum gastrin was 100 pg/ml compared to the adult median of 39 pg/ml. The newborn mean was 135 pg/ml and the corresponding adult value was 40 pg/ml (P < 0.001). Twenty-nine newborns had gastrin determinations greater than 200 pg/ml; five were greater than 500 pg/ml. All adult values were less than 200 pg/ml.Thirty-five neonatal and maternal factors were analyzed to determine their effect on the gastrin levels found. No factor was found to have a significant effect except that Negro infants and maternal sickle cell trait were found to be associated with increased values. Nineteen maternal medications were also evaluated. None, including oxytocin and atropine, were found to have any effect.Serum gastrin levels continued to be elevated at hour 4 (x = 80 pg/ml) and hour 8 (x = 72 pg/ml) of life. The newborns secreted small amounts-of gastric acid in response to this stimulus (range = 0.010 to 0.022 mEq/kg/hr).

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Neonatal secretion of gastrin and glucagon

Cited by 81 publications

References 18 publications

Neonatal gastric hyperacidity: further analysis of oxytocin effect.

Neonatal gastric hyperacidity: further analysis of oxytocin effect.

Elevated Plasma Peptide YY in Human Neonates and Infants

Human Newborn Hypergastrinemia: An Investigation of Prenatal and Perinatal Factors and Their Effects on Gastrin

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