Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019

Fathi, Afshin; Barak, Manouchehr; Damandan, Mahshid; Amani, Firouz; Moradpour, Rouhallah; Khalilova, Irada; Valizadeh, Mehdi

doi:10.55705/cmbr.2021.138793.1000

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…An association of VDR gene polymorphisms with T1DM was shown in the Chinese Hans (22), Taiwan (23), Saudi Arabia (24), Korea (25), and Spain (26). Recent reviews and metaanalyses have explored the link between hereditary distinction in vitamin D genes and diabetes (27)(28)(29). Given the disparities in findings between population/ethnic groups, we investigated the incidence of two VDR gene variants in Iraqi Kurds in Erbil and their association with T1DM patients.…”

Section: Resultsmentioning

confidence: 99%

VDR Gene Polymorphisms in Kurdish Population and Its Relation to T1DM in Erbil-Iraq

Othman

2022

Cell Mol Biol (Noisy-le-grand)

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This research assessed the relationship among type 1 diabetes VDR gene polymorphisms (ApaI and TaqI) in the Kurdish population in Erbil-Iraq. Forty individuals with type 1 diabetes and thirty healthy people were recruited from the Kurdish population in Erbil, Iraq. Genomic DNA was taken from blood, being genotyped for SNP (single nucleotide polymorphisms). The distribution of VDR polymorphisms in two restriction fragment length polymorphism sites, TaqI and ApaI, was investigated in patients and controlled by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) utilizing ApaI and TaqI restriction enzymes. Using SPSS software (V15.0), the genotype dispersal and allelic incidences in patients and controls were compared. VDR polymorphism genotype dispersal and allele incidences vary dramatically among patients and controls. The results confirmed that the genotype GT in SNP ApaI was a risk factor among type 1 diabetes mellitus patients' combination that imparted the strongest susceptibility to T1DM (P=0.00023). Still, the SNP TaqI showed no relevance between cases and controls (P=0.35). Our findings indicate that VDR gene polymorphisms in the combination of genotypes are related to an increased risk of T1DM in the Kurdish community and warrant further investigation as a possible genetic risk marker for T1DM. More research is needed to corroborate this finding, particularly the VDR gene, which was studied for the first time in the Kurdish population.

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Section: Resultsmentioning

confidence: 99%

VDR Gene Polymorphisms in Kurdish Population and Its Relation to T1DM in Erbil-Iraq

Othman

2022

Cell Mol Biol (Noisy-le-grand)

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Section: Introductionmentioning

confidence: 99%

“…In populations with high prevalence rates, early detection of enzyme deficiency by neonatal screening is required to take appropriate measures [9][10][11]. Based on the screening and related prevalence, a few countries have established screening programs to prevent severe jaundice in children [9,11]. However, the epidemiology-including prevalence or incidence of the disease, distribution by gender, and risk factors of the disease-may be helpful in developing country-specific screening and diagnostic guidelines.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in Arab Countries: Insights from a Systematic Review

Alangari,

El-Metwally,

Alanazi

et al. 2023

JCM

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common metabolic disorder affecting more than 400 million individuals worldwide. Being an X-linked disorder, the disease is more common among males than females. Various Arab countries estimated the prevalence of G6PD deficiency; however, findings from different countries have not been synthesized collectively. Hence, a systematic review was undertaken to synthesize the findings on the epidemiology of G6PD deficiency in all Arab countries. We performed an electronic systematic literature search based on the eligibility criteria using databases, including MEDLINE, Embase, and CINHAL. The studies included in the review were primary and original research studies assessing the prevalence or incidence, risk factors, or determinants of G6PD deficiency, and published in the English language in a peer-reviewed scientific journal between 2000 and 2022. The systematic review was carried out with the help of an updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. After the screening, 23 full texts were finalized for data extraction. The prevalence of G6PD deficiency ranged from 2 to 31% with a greater burden among high-risk populations like neonates with sickle cell anemia. The determinants included males, family history, consanguineous marriages, and geographic regions, which were all risk factors, except for body weight, which was a protective factor. The prevalence of G6PD deficiency varies across Arab countries, with a higher prevalence in males than females. Different regions of Arab countries need to revisit their screening and diagnostic guidelines to detect G6PD deficiency promptly and prevent unnecessary morbidity and mortality among their communities.

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“…Sweeteners are compounds that have sweetening properties and are divided into two categories of natural and artificial sweeteners [1]. In recent years, the development of natural sweeteners has greatly increased, especially natural sweeteners containing sucrose that is not absorbed in the digestive system and is not caloric, and are suitable for diabetes and obese people [2][3][4]. One of these promising natural sweeteners is steviol glycosides (SGs).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes

Mirzaei

Shakoory-Moghadam

2022

Cell. Mol. Biomed. Rep.

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Different groups of enzymes and regulatory elements are involved in the synthesis of Ribodioside A, which is one of the most important sweetening compounds in stevia. The UGT family (UDPglycosyltransferase) is a group of regulatory genes that are very effective in converting steviol glycoside to Ribodioside A. Bioinformatics analyses on this gene family, which included the UGT74G1, UGT76G1, and UGT85C2 genes, showed that the protein encoded by these genes had a UDPGT protected protein domain. Also, the study of the secondary structure of these proteins showed that the total corrosion of these proteins is mainly from alpha-helix and random screws or loops that are connected with linear strands. Also, the study of the secondary structure of these proteins showed that the total corrosion of these proteins is mainly from alpha-helix and random screws or loops that are connected with linear strands. The results of studying the three-dimensional structure of the studied proteins confirmed the previous findings of high genomic similarity between these proteins. The results of the ProtScale program showed that the abundance of amino acids with negative hydropathicity in the sequence of these proteins is high, which is effective in creating plant resistance to drought stress. Finally, the codon preference trend of these proteins was investigated using the sequence manipulation suite database. This information can be used for other research, including the transfer of these proteins.

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Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019

Cited by 7 publications

References 17 publications

VDR Gene Polymorphisms in Kurdish Population and Its Relation to T1DM in Erbil-Iraq

VDR Gene Polymorphisms in Kurdish Population and Its Relation to T1DM in Erbil-Iraq

Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in Arab Countries: Insights from a Systematic Review

Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes

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