Neonatal respiratory dysfunction and neuropsychological performance at the preschool age: A study of very preterm infants with bronchopulmonary dysplasia.

Newman, Julie Bapp; DeBastos, Angela Gustafson; Batton, Daniel G.; Raz, Sarah

doi:10.1037/a0023895

Cited by 21 publications

(18 citation statements)

References 48 publications

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“…1–3,6,7,39 Although BPD may play an important role in the long-term outcomes of preterm infants, our findings show that increased IsoPs between days 14 and 28 are associated with both worse respiratory disease at term equivalent age and with worse neurodevelopmental scores in the first year. OS, therefore, may be a common antecedent to both outcomes instead of early respiratory status directly affecting neurodevelopmental outcomes.…”

Section: Discussionmentioning

confidence: 58%

Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants

Matthews¹,

Aschner

Stark

et al. 2016

J Perinatol

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OBJECTIVE This study examined the association between increased early oxidative stress, measured by F2-isoprostanes (IsoPs), and respiratory morbidity at term equivalent age and neurological impairment at 12 months of corrected age (CA). STUDY DESIGN Plasma samples were collected from 136 premature infants on days 14 and 28 after birth. All participants were infants born at ≤28 weeks of gestational age enrolled into the Prematurity and Respiratory Outcomes Program (PROP) study. Respiratory morbidity was determined at 40 weeks of postmenstrual age (PMA) by the Respiratory Severity Index (RSI), a composite measure of oxygen and pressure support. Neurodevelopmental assessment was performed using the Developmental Assessment of Young Children (DAYC) at 12 months of CA. Multivariable logistic regression models estimated associations between IsoP change, RSI and DAYC scores. Mediation analysis was performed to determine the relationship between IsoPs and later outcomes. RESULTS Developmental data were available for 121 patients (90% of enrolled) at 12 months. For each 50-unit increase in IsoPs, regression modeling predicted decreases in cognitive, communication and motor scores of − 1.9, − 1.2 and − 2.4 points, respectively (P<0.001). IsoP increase was also associated with increased RSI at 40 weeks of PMA (odds ratio = 1.23; P = 0.01). RSI mediated 25% of the IsoP effect on DAYC motor scores (P = 0.02) and had no significant impact on cognitive or communication scores. CONCLUSIONS In the first month after birth, increases in plasma IsoPs identify preterm infants at risk for respiratory morbidity at term equivalent age and worse developmental outcomes at 12 months of CA. Poor neurodevelopment is largely independent of respiratory morbidity.

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Section: Discussionmentioning

confidence: 58%

Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants

Matthews¹,

Aschner

Stark

et al. 2016

J Perinatol

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“…Nonoxygen-dependent children with BPD have been reported to catch up developmentally at 2 years of age, whereas those initially discharged home on oxygen have been reported to catch up by 4 years of age, 114 but infants who required mechanical ventilation at 36 weeks PMA were 6 times more likely to have quadriparesis compared with infants who required only supplemental oxygen at 36 weeks PMA. 115 Close neurodevelopmental follow-up can provide parents with reassurance and education on appropriate developmental milestone attainment, specific to the child’s chronologic age and degree of prematurity.…”

Section: Transitional and Postdischarge Care Of Infants With Sbpdmentioning

confidence: 99%

Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

Abman

Collaco

Shepherd

et al. 2017

The Journal of Pediatrics

329

345

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“…These risk factors include intra-uterine growth restriction, 15,16 severe infections, [17][18][19] and bronchopulmonary dysplasia. [20][21][22] Intra-uterine growth restriction Intra-uterine growth restriction has long been identified as a risk factor for a wide variety of developmental problems in term and preterm children. 23 In particular, children born very preterm with intra-uterine growth restriction are at increased risk, not only for motor problems but also for behavioural and cognitive impairments.…”

Section: Specific Risk Factors For Impaired Fine Motor Skills At Schomentioning

confidence: 99%

“…20 It has been reported that impaired fine motor skills are related to the severity of bronchopulmonary dysplasia, reflected in the duration of oxygen treatment. 21 Treatment with systemic corticosteroids of children with bronchopulmonary dysplasia, in particular dexamethasone, is another risk factor for development of severe motor disorders such as CP. 25 Recently, data have been presented on a case-control study of preterm children with bronchopulmonary dysplasia who had been treated with dexamethasone.…”

Section: Bronchopulmonary Dysplasia and Dexamethasone Treatmentmentioning

confidence: 99%

Development of fine motor skills in preterm infants

Bos

Braeckel

Hitzert

et al. 2013

Develop Med Child Neuro

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ASQAges and Stage Questionnaire BOTMP Bruininks-Oseretsky Test of Motor Proficiency MABC Movement Assessment Battery for ChildrenFine motor skills are related to functioning in daily life and at school. We reviewed the status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. We searched the past 15 years in PubMed, using ['motor skills' or 'fine motor function' and 'preterm infant'] as the search string. Impaired gross and fine motor skills are among the most frequently occurring problems encountered by preterm children who do not develop cerebral palsy. The prevalence is around 40% for mild to moderate impairment and 20% for moderate impairment. Fine motor skill scores on the Movement Assessment Battery for Children are about 0.62 of a standard deviation lower compared with term children. Risk factors for fine motor impairments include moderately preterm birth (odds ratio [OR] 2.0) and, among very preterm children (<32wk gestation), intra-uterine growth restriction (ORs 2-3), inflammatory conditions (late-onset sepsis and necrotizing enterocolitis, ORs 3-5), and dexamethasone therapy for bronchopulmonary dysplasia (OR 2.7).A better understanding of factors that play a role in the development of and recovery from brain injury could guide future intervention attempts aimed at improving fine motor skills of preterm children.Survival rates of preterm infants have improved during recent decades, and this tendency is continuing. During the same period, the prevalence of major impairments has remained relatively constant or even decreased, 1 but the prevalence of milder dysfunctions is high, 2,3 with a tendency to increase. 4,5 This mainly appears to be the result of the increased survival of very preterm infants (gestational age <32wk), although more sensitive testing may also play a role. 5 Cognitive, behavioural, and mild motor problems without major motor deficits are by now the most dominant neurodevelopmental sequelae in children born preterm, with prevalences reported up to 50 to 70%.5 These 'high prevalence, low severity' impairments often do not occur in isolation and may considerably hamper the children's functional abilities in daily life. 6,7 Among the most frequently occurring problems encountered by preterm children who do not develop cerebral palsy (CP), are impaired gross and fine motor skills.2,4 Because particularly fine motor skills are related to adequate functioning in daily life and at school, our aim was to review the current status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. To this end, we searched PubMed for relevant articles.Impairments in fine motor skills may hamper various aspects of daily functioning such as getting dressed, lacing shoes, eating, and writing. In preterm children without CP, it has been shown that poor fine motor skills affect the learning of w...

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Neonatal respiratory dysfunction and neuropsychological performance at the preschool age: A study of very preterm infants with bronchopulmonary dysplasia.

Abstract: A significant, yet circumscribed, association was demonstrated between neonatal hypoxic risk, in the VP infant, and neuropsychological outcome assessed in the preschool years.

Cited by 21 publications

References 48 publications

Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants

Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants

Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

Development of fine motor skills in preterm infants

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