Neonatal paternal deprivation impairs social recognition and alters levels of oxytocin and estrogen receptor α mRNA expression in the MeA and NAcc, and serum oxytocin in mandarin voles

Cao, Yan; Wu, Ruiyong; Tai, Fadao; Zhang, Xia; Yu, Peng; An, Xiaolei; Qiao, Xufeng; Hao, Ping

doi:10.1016/j.yhbeh.2013.11.005

Cited by 69 publications

(71 citation statements)

References 85 publications

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“…Furthermore, in mandarin voles (Microtus mandarimus) paternal deprivation leading to impaired social recognition, was associated with a reduction in oxytocin receptors in the medial amygdala and nucleus accumbens 154 . Whether these modifications have a role in stress-related changes in social behaviors has been investigated.…”

Section: Oxytocin and Vasopressinmentioning

confidence: 99%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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Section: Oxytocin and Vasopressinmentioning

confidence: 99%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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“…In socially monogamous and biparental species, deprivation of paternal care can result in reduced social recognition (Cao et al, 2014), altered development of play behavior , impaired pair-bonding , and increased anxiety-like behavior (Jia et al, 2009). These behavioral impairments are associated with paternal deprivation-induced neurobiological changes, including sex-specific effects on dopamine receptor gene expression in the nucleus accumbens , reductions in oxytocin receptor and ER alpha (ERa) levels (Cao et al, 2014), altered development of neuroendocrine pathways involved in the response to stress (Seidel et al, 2011), and reduced neuronal complexity (Braun et al, 2013;Pinkernelle et al, 2009). In the biparental California mouse, paternal behavior has been shown to alter the development of neural systems involved in aggression, with implications for variation in paternal behavior in male offspring (Frazier et al, 2006;Gleason and Marler, 2013).…”

Section: Studies Of Paternal Influences On Offspring Development In Rmentioning

confidence: 99%

Early-Life Experience, Epigenetics, and the Developing Brain

Kundaković

Champagne

2014

Neuropsychopharmacol

251

182

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Development is a dynamic process that involves interplay between genes and the environment. In mammals, the quality of the postnatal environment is shaped by parent-offspring interactions that promote growth and survival and can lead to divergent developmental trajectories with implications for later-life neurobiological and behavioral characteristics. Emerging evidence suggests that epigenetic factors (ie, DNA methylation, posttranslational histone modifications, and small noncoding RNAs) may have a critical role in these parental care effects. Although this evidence is drawn primarily from rodent studies, there is increasing support for these effects in humans. Through these molecular mechanisms, variation in risk of psychopathology may emerge, particularly as a consequence of early-life neglect and abuse. Here we will highlight evidence of dynamic epigenetic changes in the developing brain in response to variation in the quality of postnatal parent-offspring interactions. The recruitment of epigenetic pathways for the biological embedding of early-life experience may also have transgenerational consequences and we will describe and contrast two routes through which this transmission can occur: experience dependent vs germline inheritance. Finally, we will speculate regarding the future directions of epigenetic research and how it can help us gain a better understanding of the developmental origins of psychiatric dysfunction.

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“…Such studies have identified several socio-behavioural deficits associated with paternal absence. For example, the absence of fathers in the natal nest of bi-parental rodents adversely influences maturation, partner-preference formation, alloparental behaviour, aggression and social recognition in adulthood [6][7][8][9][10][11][12]. However, in order to fully understand the influence of early life experiences on development, we must consider the impact of social environments beyond the natal nest.…”

Section: Introductionmentioning

confidence: 99%

Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles

et al. 2015

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Social environments experienced at different developmental stages profoundly shape adult behavioural and neural phenotypes, and may have important interactive effects. We asked if social experience before and after weaning influenced adult social cognition in male prairie voles. Animals were raised either with or without fathers and then either housed singly or in sibling pairs. Males that were socially deprived before (fatherless) and after (singly housed) weaning did not demonstrate social recognition or dissociate spatial from social information. We also examined oxytocin and vasopressin receptors (OTR and V1aR) in areas of the forebrain associated with social behaviour and memory. Pre-and post-wean experience differentially altered receptor expression in several structures. Of note, OTR in the lateral septum-an area in which oxytocin inhibits social recognition-was greatest in animals that did not clearly demonstrate social recognition. The combination of absentee fathers on V1aR in the retrosplenial cortex and single housing on OTR in the septohippocampal nucleus produced a unique phenotype previously found to be associated with poor reproductive success in nature. We demonstrate that interactive effects of early life experiences throughout development have tremendous influence over brain -behaviour phenotype and can buffer potentially negative outcomes due to social deprivation.

show abstract

Neonatal paternal deprivation impairs social recognition and alters levels of oxytocin and estrogen receptor α mRNA expression in the MeA and NAcc, and serum oxytocin in mandarin voles

Cited by 69 publications

References 85 publications

Stress and the social brain: behavioural effects and neurobiological mechanisms

Stress and the social brain: behavioural effects and neurobiological mechanisms

Early-Life Experience, Epigenetics, and the Developing Brain

Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles

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