Neonatal outcomes of pregnant women diagnosed with SARS-CoV-2: an integrative review

Abstract

The present study analyzed the neonatal outcomes reported in pregnant women with COVID-19. An integrative review was carried out after formulating the guiding question. That done, the research strategy, selection of criteria and data extraction were carried out. The searches were performed in the databases "PubMed", "Web of Science", "LILACS" and "ScienceDirect" using the following search terms: 2019-nCoV, covid-19, SARS-CoV-2, pregnant, pregnancy, birth, fetal, neonatal, outcomes, complications and adverse. The studies involved 226 pregnant women diagnosed with COVID-19 and 174 healthy pregnant women. Among the 226 pregnant women with COVID-19, there was 01 intrauterine fetal death and 16 remained pregnant until the end of the respective studies. Thus, 209 pregnant women with COVID-19 evolved for childbirth, resulting in 212 live births. Of these, 127 (59.9%) were born by cesarean delivery, 38 (17.9%) were born at <37 weeks of gestational age [3 (1.4%) <28 weeks] and 16 (7.5) were born at weight <2500 g. Neonatal results included 8 (3.8%) with a positive SARS-CoV-2 test, 12 (5.7%) with fetal distress, neonatal asphyxia, vomiting or skin rashes, 2 (0.9%) with intravascular coagulation disseminated, 1 (0.5%) alteration of cardiac enzymes, 1 (0.5%) multiple organ failure and 1 (0.5%) neonatal death. Various complications have been identified in pregnant women with COVID-19, therefore, a greater care must be given to this population group due to a greater risk of neonatal complications.