Neonatal outcome of small for gestational age preterm infants

Nobile, Stefano; Marchionni, Paolo; Carnielli, Virgilio P.

doi:10.1007/s00431-017-2957-1

Cited by 48 publications

(55 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite similar GA, incidence, and severity of surfactant‐treated respiratory distress syndrome, infants with BPD had more persistent respiratory morbidity, and subsequently an increased need for respiratory support in the NICU. Although SGA is a known risk factor for BPD and other adverse clinical outcomes, we do not think that this was an important aspect in the present study, because there was no significant weight difference between the groups at discharge. To our knowledge there are few studies on the incidence of neonatal pneumonia in BPD.…”

Section: Discussionsupporting

confidence: 86%

“…In an updated publication by the same authors, children with BPD also higher rates of cognitive, educational and behavioral problems . Differences in reported ND outcomes may be due to a number of reasons such as the selected patient population, BPD definition and severity, incidence and severity of major comorbidities, treatment protocols, methods and time points of ND assessment, socioeconomic status, or the observation period . There are some ND follow‐up studies for BPD patients longer than 2 years for CA.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Reiterer

Scheuchenegger

Resch

et al. 2019

Pediatrics International

View full text Add to dashboard Cite

BackgroundBronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long‐term outcome.MethodsThis was a retrospective, single‐center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24+0–28+6 weeks) with BPD (n = 44), with a cohort of GA‐matched preterm infants without BPD (n = 44) with regard to neonatal morbidity, incidence of lower respiratory tract infection (LRTI), ND outcome and growth to 2 years' corrected age (CA) and preschool age.ResultsBronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028).ConclusionNeonatal respiratory morbidity was significantly higher in the BPD cohort, but long‐term ND outcome did not differ. Infants with BPD had poorer growth.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Reiterer

Scheuchenegger

Resch

et al. 2019

Pediatrics International

View full text Add to dashboard Cite

show abstract

“…Some studies suggested that also preterm infants without BPD, particularly those born small for gestational age, experience various degrees of lung impairment during their Neonatal Intensive Care Unit (NICU) stay and in later life . Some authors suggested a possible association between the severity of respiratory disease in the neonatal period and the degree of respiratory dysfunction in childhood .…”

Section: Introductionmentioning

confidence: 99%

Oxygen saturation/FIO2 ratio at 36 weeks’ PMA in 1005 preterm infants: Effect of gestational age and early respiratory disease patterns

Nobile¹,

Marchionni²,

Gidiucci³

et al. 2019

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Small for gestational age (SGA) may have a negative influence on BPD due to poor nutrition and growth in the uterine environment, for example, increased healthcare utilization in those with BPD and SGA compared with those without SGA, and development of BPD in those born SGA . It can also influence respiratory outcomes in adulthood; prenatal treatments reversing the later adverse effect of SGA are considered to be important .…”

Section: Introductionmentioning

confidence: 99%

“…3,7 Small for gestational age (SGA) may have a negative influence on BPD due to poor nutrition and growth in the uterine environment, for example, increased healthcare utilization in those with BPD and SGA compared with those without SGA, and development of BPD in those born SGA. [8][9][10][11][12][13][14] It can also influence respiratory outcomes in adulthood; prenatal treatments reversing the later adverse effect of SGA are considered to be important. 15 Moreover, the incidence of BPD was reported to increase up to 50% in very low birth weight infants, and the burden of SGA in low-and middle-income countries was reported to be quite high.…”

mentioning

confidence: 99%

Small for gestational age birth may increase airflow limitation in bronchopulmonary dysplasia

Kim

Eun

et al. 2019

Pediatric Pulmonology

View full text Add to dashboard Cite

Objectives To determine significant indices for assessing the pulmonary function of infants according to bronchopulmonary dysplasia (BPD) severity and to evaluate whether small for gestational age (SGA) could affect pulmonary function in BPD. Methods We evaluated 117 preterm infants who had undergone tidal breathing flow‐volume loop and multiple‐breath washout analyses within 7 months after birth. We categorized preterm infants according to BPD severity into mild/moderate BPD (n = 86), severe BPD (n = 21), and without BPD (n = 10) and the presence of SGA or appropriate gestational age (AGA) using the Fenton growth chart. We evaluated nine healthy term infants as controls. Results The tidal breathing ratio (time to peak expiratory flow/expiratory time [tPEF/tE]) was significantly lower in infants with severe BPD than in those with mild/moderate BPD. Lung clearance index (LCI) was not different based on BPD severity. In the correlation analysis after adjusting for gestational age and sex, tPEF/tE was correlated with the duration of mechanical ventilation (r = −0.347, P < .001) and the duration of oxygen supply (r = −0.248, P = .013) in infants with BPD. The proportion of “lower tPEF/tE,” defined as below the cut‐off value, was greater in SGA infants (P = .017), while no significant difference was seen in the percentage of “higher LCI,” defined as above the cut‐off value between SGA and AGA infants. Conclusions In infants with BPD, tPEF/tE could be a useful pulmonary index which shows lower values in severe BPD. The finding of SGA in infants with BPD could be associated with poor pulmonary function related to the tPEF/tE values.

show abstract

Neonatal outcome of small for gestational age preterm infants

Cited by 48 publications

References 45 publications

Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Oxygen saturation/FIO2 ratio at 36 weeks’ PMA in 1005 preterm infants: Effect of gestational age and early respiratory disease patterns

Small for gestational age birth may increase airflow limitation in bronchopulmonary dysplasia

Contact Info

Product

Resources

About