Neonatal outcome in preterm deliveries before 34-week gestation – the influence of the mechanism of labor onset

Pinto, Sara; Malheiro, Maria Filipa; Vaz, Ana; Rodrigues, Teresa; Montenegro, Nuno; Guimarães, Hercília

doi:10.1080/14767058.2018.1481038

Cited by 11 publications

(10 citation statements)

References 33 publications

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“…Few studies have examined the immediate postnatal impact of IPTBs vs SPTBs 19,20 ; however, their short followup periods limit our understanding of the more permanent, indelible effects of the different causes of preterm delivery in this patient population. Therefore, our present study has broadened its scope beyond the neonatal population to examine how type of preterm delivery affects 2-yearold children as well.…”

Section: Results In the Context What Is Knownmentioning

confidence: 99%

Childhood neurodevelopment after spontaneous versus indicated preterm birth

Nuss

Spiegelman

Turitz

et al. 2020

American Journal of Obstetrics & Gynecology MFM

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Section: Results In the Context What Is Knownmentioning

confidence: 99%

Childhood neurodevelopment after spontaneous versus indicated preterm birth

Nuss

Spiegelman

Turitz

et al. 2020

American Journal of Obstetrics & Gynecology MFM

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“…Internal consistency reliability for 36-47 months of age is excellent (r 11 = 0.94), whereas the overall test-retest (r 12 = 0.92) and inter-scorer (r 11 = 0.98) reliability coefficients are also exceptionally high (Folio and Fewell 2000). (Barnhart 2015), hypothyroidism (Andersen et al 2018, andLiu et al 2018), diabetes (Fraser et al 2012), chorioamnionitis (Yellowhair et al 2018), preterm premature rupture of the membranes (PPROM; Pinto et al 2018), placental abruption (Downes et al 2017) and placenta previa (Weiner et al 2016). Hence, for each participant we summed the identified complications, out of the nine relatively common antenatal risks, with the following sample distribution: 0 (15%), 1 (40.62%), 2 (27.50%), 3 (13.75%) and 4 (3.10%).…”

Section: Evaluation Of Pre-kindergarten Readiness Skillsmentioning

confidence: 99%

Cumulative Antenatal Risk and Kindergarten Readiness in Preterm-Born Preschoolers

Heitzer

Piercy

Peters

et al. 2019

Res Child Adolesc Psychopathol

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A suboptimal intrauterine environment is thought to increase the probability of deviation from the typical neurodevelopmental trajectory, potentially contributing to the etiology of learning disorders. Yet the cumulative influence of individual antenatal risk factors on emergent learning skills has not been sufficiently examined. We sought to determine whether antenatal complications, in aggregate, are a source of variability in preschoolers' kindergarten readiness, and whether specific classes of antenatal risk play a prominent role. We recruited 160 preschoolers (85 girls; ages 3-4 years), born ≤33 6 / 7 weeks' gestation, and reviewed their hospitalization records. Kindergarten readiness skills were assessed with standardized intellectual, oral-language, prewriting, and prenumeracy tasks. Cumulative antenatal risk was operationalized as the sum of complications identified out of nine common risks. These were also grouped into four classes in follow-up analyses: complications associated with intra-amniotic infection, placental insufficiency, endocrine dysfunction, and uteroplacental bleeding. Linear mixed model analyses, adjusting for sociodemographic and medical background characteristics (socioeconomic status, sex, gestational age, and sum of perinatal complications) revealed an inverse relationship between the sum of antenatal complications and performance in three domains: intelligence, language, and prenumeracy (p = 0.003, 0.002, 0.005, respectively). Each of the four classes of antenatal risk accounted for little variance, yet together they explained 10.5%, 9.8%, and 8.4% of the variance in the cognitive, literacy, and numeracy readiness domains, respectively. We conclude that an increase in the co-occurrence of antenatal complications is moderately linked to poorer kindergarten readiness skills even after statistical adjustment for perinatal risk.

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“…Approximately 30% of preterm births are preceded by preterm prelabor rupture of membranes (pPROM) [4][5][6][7][8][9][10][11][12], defined as the rupture of the chorioamniotic membranes before the onset of preterm labor (i.e. <37 weeks) [4,[6][7][8][9][10][11][12]; thus, this clinical condition is a major contributor to maternal and neonatal morbidity [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. pPROM is considered a great obstetrical syndrome [32][33][34][35][36] and has recently been subcategorized using microbiological techniques coupled with amniotic fluid concentrations of interleukin-6 (IL-6) [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Galaz

Romero

Slutsky

et al. 2020

Journal of Perinatal Medicine

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Background Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not been investigated. Methods Amniotic fluid samples were obtained from women with pPROM and a positive (n = 7) or negative (n = 10) microbiological culture. Flow cytometry was performed to evaluate the phenotype and number of amniotic fluid leukocytes. The correlation between amniotic fluid immune cells and an interleukin-6 (IL-6) concentration or a white blood cell (WBC) count in amniotic fluid was calculated. Results Women with pPROM and a positive amniotic fluid culture had (1) a greater number of total leukocytes in amniotic fluid, including neutrophils and monocytes/macrophages and (2) an increased number of total T cells in amniotic fluid, namely CD4+ T cells and CD8+ T cells, but not B cells. The numbers of neutrophils and monocytes/macrophages were positively correlated with IL-6 concentrations and WBC counts in amniotic fluid of women with pPROM. Conclusion Women with pPROM and a positive amniotic fluid culture exhibit a more severe cellular immune response than those with a negative culture, which is associated with well-known markers of intra-amniotic inflammation.

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Neonatal outcome in preterm deliveries before 34-week gestation – the influence of the mechanism of labor onset

Cited by 11 publications

References 33 publications

Childhood neurodevelopment after spontaneous versus indicated preterm birth

Childhood neurodevelopment after spontaneous versus indicated preterm birth

Cumulative Antenatal Risk and Kindergarten Readiness in Preterm-Born Preschoolers

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

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