Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer

Kato, Osamu; Kawasaki, Nami; Bodri, Daniel; Kuroda, Tomoko; Kawachiya, Satoshi; Kato, Keiichi; Takehara, Y.

doi:10.1016/j.ejogrb.2011.12.005

Cited by 99 publications

(57 citation statements)

References 31 publications

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“…The stimulation of the endometrium by Tamoxifen [8] compared to Clomiphene might explain the high implantation rate found in this study. This preliminary study supports previous findings by Kato et al [4,5], reporting the same high pregnancy rate in fresh cycles using low stimulation. Adding the frozen thaw data will undoubtedly increase the success rates.…”

Section: Resultssupporting

confidence: 82%

“…The wide spread use of single embryo transfer makes is unnecessary to harvest more than a few eggs in an IVF cycle [4]. It has been demonstrated that the health of off-springs from mild stimulation is comparable to conventional IVF [5]. The potential negative effect of Clomiphene on the endometrium might be overcome by transferring the embryos in later cycles using vitrification of the embryos [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low Ovarian Stimulation Using Tamoxifen/FSH Compared to Conventional IVF: A Cohort Comparative Study in Conventional IVF Treatments

Lindenberg¹

2012

Reprod Syst Sex Disord

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Section: Resultssupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Low Ovarian Stimulation Using Tamoxifen/FSH Compared to Conventional IVF: A Cohort Comparative Study in Conventional IVF Treatments

Lindenberg¹

2012

Reprod Syst Sex Disord

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“…In fact, others have presented evidence suggestive of impaired endometrial receptivity after ovarian stimulation for IVF in a prospective randomized trial comparing fresh and frozen-thawed blastocyst transfer in normal responders [36]. This information combined with reported very high survival rates following vitrification/warming [37,38], may provide an alternative to the routine IVF approach [39]. Notwithstanding the introduction or not of these potential practice changes, more data are needed to determine optimal endometrial preparation in artificial cycles resulting in adequate E 2 levels and E2/P4 ratios for achievement of highest receptivity and implantation.…”

Section: Discussionmentioning

confidence: 86%

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Bocca

Real

Lynch

et al. 2015

J Assist Reprod Genet

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Purpose To investigate the impact of late follicular phase serum estradiol (E 2 ) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement. Methods Retrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E 2 and progesterone (P4) supplemented cycles (n=208 cycles). Main outcome measures: implantation and pregnancy rates according to late follicular phase serum E 2 levels and early secretory phase E 2 /P4 ratios. Results Logistic regression performed for embryo implantation and for pregnancy outcome in relation to E 2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E 2 /P4 ratio. Conclusions Neither late follicular phase serum E 2 nor the early E 2 /P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.

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“…Most published reports looking at the neonatal outcomes after transfer of vitrified embryos have used blastocyst-stage embryos (Takahashi et al, 2005;Mukaida et al, 2009;Wikland et al, 2010). Reported data on children born after transfer of Day 3 vitrified embryos are relatively rare (Rama Raju et al, 2009;Kato et al, 2012;Shi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Obstetric and neonatal outcomes after transfer of vitrified early cleavage embryos

Liu

Teng

et al. 2013

Human Reproduction

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what is known already: Vitrification has been successfully used for cryopreserving human oocytes and blastocyst-stage embryos. Most published studies looking at the neonatal outcomes after transfer of vitrified embryos refer to blastocyst-stage embryos. Information on children born after transfer of Day 3 vitrified embryos is relatively rare. study design, size, duration: A retrospective, single-centre study of children born after Day 3 embryo transfer from fresh, slow frozen or vitrified embryos during the period January 2006 to May 2011 was conducted. Each patient contributed only one cycle per group. Children born were followed-up at 7-30 days after delivery. Outcome measures include obstetric and neonatal outcomes, which were evaluated by medical records and questionnaires sent to parents. main results and the role of chance: Frequencies of hypertensive disorder, gestational diabetes, placenta previa and abruptio placenta were similar in all groups. Five hundred and forty five, 986 and 1914 singleton babies were born from vitrified, slow freezing and fresh transfers, and the median gestational ages were 38.7, 38.7 and 38.7 weeks, respectively. Preterm birth (32 -37 weeks) occurred in 7.5, 9.2 and 7.8% of the vitrified, slow freeze and fresh groups, respectively. The median birthweight from vitrified embryos (3455.3 g) was higher than that from slow freezing (3352.3 g) and fresh (3355.8 g) transfers (P , 0.0001 for both). The rate of perinatal mortality was 0.4% for all transfer groups. Three hundred and eighty two, 734 and 1322 twin babies were born from vitrified, slow freezing and fresh transfers, respectively. There were no differences among groups in mean gestational age and in the rate of preterm birth. The median birthweight for babies born from vitrified embryos (2587.4 g) was higher than that from the slow freezing (2538.8 g) or fresh (2494.4 g) transfer groups (vitrified versus fresh: P ¼ 0.0015; vitrified versus slow freeze: P ¼ 0.049). The rate of low birthweight (1500-2500 g) from vitrified (30.4%) was lower than that from fresh (36.2%) transfer (P ¼ 0.034).limitations, reasons for caution: The main limitation of this study is that the obstetric and neonatal data were obtained by questionnaires sent to the parents without checking medical records. This is, especially, problematic for reporting on congenital malformations, so birth defects were excluded from the data.wider implications of the findings: Transfer of vitrified and warmed Day 3 embryos does not seem to have an adverse effect on neonatal outcome. Children born following the transfer of vitrified embryos seem to have a higher birthweight when compared with those of fresh or slow frozen embryos. study funding/competing interest(s): This study received no outside funding and none of the authors has any conflict of interest.

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Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer

Cited by 99 publications

References 31 publications

Low Ovarian Stimulation Using Tamoxifen/FSH Compared to Conventional IVF: A Cohort Comparative Study in Conventional IVF Treatments

Low Ovarian Stimulation Using Tamoxifen/FSH Compared to Conventional IVF: A Cohort Comparative Study in Conventional IVF Treatments

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Obstetric and neonatal outcomes after transfer of vitrified early cleavage embryos

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