Neonatal Osteomyelitis with Pathologic Fracture of Mandible Following MRSA Septicemia: Management and Three Year Follow Up

Joseph, Paul V.; Haridas, Ajay Kumar

doi:10.1007/s12663-011-0312-z

Cited by 4 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore of great importance to detect reliable biomarkers for early diagnosis of neonatal septicemia [6]. In the intensive care unit, neonatal septicemia, which is mainly caused by drug-resistant bacteria, is not only life-threatening, but may also lead to long-term sequelae [7]. C-reactive protein (CRP) is a sensitive indicator of inflammation in humans; it activates the complement system and promotes granulocyte and macrophage phagocytosis, which is the most commonly used test for diagnosis of neonatal sepsis.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of C-Reactive Protein Test for Neonatal Septicemia: A Diagnostic Meta-Analysis

Liu

Zhao

2019

Med Sci Monit

View full text Add to dashboard Cite

Background The aim of this study was to evaluate the diagnostic value of C-reactive protein (CRP) test in detecting neonatal septicemia. Material/Methods We searched the Cochrane Library, PubMed, Springer, MBASE, Elsevier Science Direct, and Medline databases up to March 2017. To collect relevant data on CRP testing in patients with neonatal septicemia, we performed a meta-analysis of positive likelihood ratio (LR), sensitivity, negative LR, specificity and diagnostic odds ratio (dOR) of CRP testing, using Stata 12.0 and Meta-DiSc 1.4 data analysis software. Results Ten studies including 1819 participants were considered in this study. We found that positive LR, sensitivity, negative LR, specificity, and dOR of the CRP test for neonatal septicemia were 5.63 (95% CI=2.86 to 11.09), 0.70 (95% CI=0.66 to 0.75), 0.36 (95% CI=0.21 to 0.60), 0.89 (95% CI=0.87 to 0.91), and 17.99 (95% CI=6.50 to 49.83), respectively. The AUC and Q* index of this meta-analysis were 0.90 and 0.83, respectively. Conclusions The area under the curve (AUC), negative LR, positive LR, Q* index, specificity, and dOR of the CRP test suggest that it is appropriate for detecting neonatal septicemia.

show abstract

Section: Introductionmentioning

confidence: 99%