Neonatal Osteomyelitis

Kiechl‐Kohlendorfer, Ursula; Griesmaier, Elke

doi:10.5772/54320

Cited by 8 publications

(14 citation statements)

References 37 publications

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“…All 216 included patients received intravenous therapy at admission for median 21 days (IQR 15.5-28.5): other type osteomyelitis group received intravenous therapy with a median duration of 21 days IQR (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), neonatal-onset osteomyelitis group of 33 days (IQR 27-44), while the spondylodiscitis group for 25.5 days (IQR [19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Resultsmentioning

confidence: 99%

“…Empiric antibiotic therapy must include an antistaphylococcal molecule (nafcillin or oxacillin) associated with a second or third generation cephalosporin (cefotaxime, ceftriaxone, ceftazidime) or an aminoglycoside (gentamicin, amikacin, tobramycin) to allow broad coverage against the main pathogens involved. In the case of neonates at high risk for nosocomial pathogens (S. aureus MRSA or coagulase negative), nafcillin should be replaced by a glycopeptide (vancomycin, teicoplanin) [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Management of Acute Hematogenous Osteomyelitis, Neonatal Osteomyelitis and Spondylodiscitis in a Third Level Paediatric Center

et al. 2021

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Acute hematogenous osteomyelitis (AHOM) is a rare pathology in pediatric population. The aim of this study is to analyse the epidemiological data and the management, compared to European Society for Paediatric Infectious Disease (ESPID, European Society for Pediatric Infectious Diseases) guidelines 2017 of 216 children with AHOM, divided in three cohorts (neonatal-onset osteomyelitis, those with vertebral involvement and other types of osteomyelitis). We conducted a retrospective single center study, evaluating data from all the children (aged 0–18 years) consecutively admitted to the Meyer Children’s Hospital, during a period of ten years (1 January 2010–31 December 2019). Isolation of pathogen was possible in 65 patients and S. aureus was the most frequently involved (43/65 children). Magnetic Resonance Imaging (MRI, magnetic resonance imaging) was performed in 201/216 cases and was compatible with osteomyelitis in 185/201 of these children (92.03%). In the neonatal-onset osteomyelitis group the percentage of diagnostic ultrasound for osteomyelitis was 36.36% significantly higher than the other groups. The median duration of total antibiotic therapy was 37.5 days. In total, 186/199 children recovered without complications. The present study delineates three heterogeneous cohorts of patients. S. aureus is confirmed as the first pathogen for isolation in all three groups analysed. MRI represent a gold standard for diagnosis. Longer duration of antibiotics treatment was performed in neonatal and spondylodiscitis group, compared to the other types of osteomyelitis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology and Management of Acute Hematogenous Osteomyelitis, Neonatal Osteomyelitis and Spondylodiscitis in a Third Level Paediatric Center

et al. 2021

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“…They all had concomitant important delays of antibiotic introduction (six to 12 days) and surgery (six to 13 days). The comparison with other studies was limited, because the definitions of orthopaedic complications and duration of the follow‐up periods were heterogeneous .…”

Section: Discussionmentioning

confidence: 99%

“…Very few studies have focused on BJIs in newborn infants and young infants and most of those concerned nosocomial infections. Staphylococcus aureus was the most common pathogen in those studies, with rates ranging from 36 to 76% of the documented cases .…”

Section: Introductionmentioning

confidence: 98%