Neonatal osteofibrous dysplasia associated with pathological tibia fracture

Abstract

Osteofibrous dysplasia is a rare and benign disease that originates from the tibia or fibula. The symptoms of osteofibrous dysplasia include painless enlargement and bowing of the tibia and pain occurring in the presence of pathological fracture. Herein a male infant who was admitted with redness and swelling on the right leg and diagnosed as pathological tibia fracture due to left tibia osteofibrous dysplasia on the third day of life was presented. To our knowledge, this is the earliest presentation of osteofibrous dysplasia with a pathological fracture in a neonate. Therefore, it must be suspected in neonatal bone fractures.

A Turkish Female Twin Sister Patient with Fibular Aplasia, Congenital Tibia Pseudoarthrosis, Oligosyndactyly, and Negative WNT7A Gene Mutation

“…Similar to WNT7A gene result, the NF1 gene sequencing analysis of coding regions and exon-intron boundaries was normal. Osteofibrous dysplasia, which is another cause of congenital pseudoarthrosis, 14 was excluded because of the absence of any specific radiological sign; also in our patient, there is an absent fibula too. Another condition in the differential diagnosis of congenital pseudarthrosis is congenital anterolateral tibial bowing and polydactyly syndrome 15 ; however, in our case, there were no signs of this syndrome, so we exclude that disease.…”

Osteofibrous dysplasia: A rare case in 3-day-old female

“…In some cases, the lesion is noted incidentally on x-ray performed for other condition. The biomechanical fragility of dysplastic bone can cause a pathological fracture or progressive bone deformity, typically anterior or anterolateral tibial bowing [8] . In a study, Park et al reported pathological fracture in 12.5% of their patient population [14] .…”

“…In a study, Park et al reported pathological fracture in 12.5% of their patient population [14] . A rare complication can be pseudarthrosis resulting from the local destructive process [ 5 , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , 15 ]. X-ray is the first chief investigation to be performed.…”

Newborn with pathologic fracture of the tibia: osteofibrous dysplasia

“…Genellikie lezyonun kendiliginden gerileyebilecegi ve özellikle 15 ya § altmdaki çocukiarda "konservatif" tedavi ile izlenebilecegi bildirilmi §tir (4,7,8,12). Çogunlukla a §in büyüme ve patolojik kirik durumunda cerrahi tedavi önerilmektedir.…”

“…Çogunlukla a §in büyüme ve patolojik kirik durumunda cerrahi tedavi önerilmektedir. Bir ya §in altmdaki çocukiarda cerrahi tedavi önerilmemektedir (4,7,8,12). Subperiostal rezeksiyon yapilan hastalarm bir kisminda bölgesel nüks saptanmiçtir (1,8).…”