Neonatal orbital abscess

Al-Salem, Khalil; Alsarayra, Fawaz A; Somkawar, Areej R

doi:10.4103/0301-4738.116447

Cited by 10 publications

(11 citation statements)

References 13 publications

(17 reference statements)

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“…Al-Salem et al ., recently highlighted eyelid retraction as a sign of neonatal orbital abscess and its subsequent spontaneous resolution following successful treatment as was seen in our case. [ 12 ] The eyelid retraction became apparent in our case on sixth day post-operatively after decrease in lid edema subsequent to treatment response. There was spontaneous subsidence of lid retraction in our case too.…”

Section: Discussionmentioning

confidence: 63%

Neonatal orbital abscess

Gogri¹,

Misra²,

Misra³

et al. 2015

Oman J Ophthalmol

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Orbital abscess generally occurs in older children but it can rarely affect infants and neonates too. We report a case of community acquired methicillin resistant staphylococcus aureus (CA-MRSA) neonatal orbital abscess in a 12-day-old term female neonate with no significant past medical history or risk factor for developing the infection. The case highlights the importance of consideration of CA-MRSA as a causative agent of neonatal orbital cellulitis even in a neonate without any obvious predisposing condition. Prompt initiation of appropriate medical therapy against MRSA and surgical drainage of the abscess prevents life threatening complications of orbital cellulitis which more often tend to be fatal in neonates.

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Section: Discussionmentioning

confidence: 63%

Neonatal orbital abscess

Gogri¹,

Misra²,

Misra³

et al. 2015

Oman J Ophthalmol

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“…Интоксикация, как правило, проявляется признаками сонливости, апатии, иногда беспокойством, отказом от еды. У большинства пациентов наблюдалась фебрильная лихорадка, хотя описаны два случая нормотермии [4]. Местно определяются нарастающий отек и гиперемия век, проптоз, экзофтальм, хемоз конъюнктивы, ограничение движений глаз, боль.…”

Section: клинический случай ретробульбарного абсцесса у новорожденногunclassified

“…В описанных в литературе случаях стартовыми антибиотиками были преимущественно препараты бета-лактамного ряда с последующей заменой их на ванкомицин или комбинации цефалоспоринов с ванкомицином или гентамицином, а также монотерапия линезолидом [4]. В большинстве случаев проводилось хирургическое дренирование, иногда дренирование происходило самопроизвольно.…”

Section: клинический случай ретробульбарного абсцесса у новорожденногunclassified

“…Неонатальный орбитальный абсцесс -заболевание очень редкое и является серьезной угрозой для жизни ребенка из-за чрезвычайно быстрого развития критических ослож-нений в виде менингита, сепсиса и отсроченных осложнений, связанных с локальным поражением глаза [2,3]. В настоящее время в литературе описано около 20 случаев неонатального орбитального абсцесса [1,4]. Основными источниками распространения воспаления являются периорбитальные структуры, так как тканевые барьеры у новорожденных не сформированы окончательно по сравнению с детьми старшего возраста и взрослыми [5].…”

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Клінічний Випадок Ретробульбарного Абсцесу У Новонародженої Дитини

Бадогина¹,

Obolonskaya²,

Dereza³

et al. 2021

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“…It was recently suggested to be the major cause of late-onset sepsis in very-low birth weight infants admitted to neonatal intensive care units in the USA and UK [5][6][7]. Data from 2005 to 2018 suggested that up to 4.4% of very-low birth weight infants in China developed S. aureus bacteremia or meningitis and osteomyelitis, with an overall mortality of 19% to 30.5% [8][9][10][11][12]. Moreover, a recent meta-analysis showed that the risk of S. aureus colonization and infection in infants was 24.2 times higher than that in adults, indicating that infants were at high risk for S. aureus colonization [10,13].…”

Section: Introductionmentioning

confidence: 99%

Thymol Disrupts Cell Homeostasis and Inhibits the Growth of Staphylococcus aureus

Huang

Pan

et al. 2022

Contrast Media & Molecular Imaging

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Staphylococcus aureus (S. aureus) is a typical kind of symbiotic bacteria, which can cause human pneumonia, food poisoning, and other health problems. Nowadays, the corresponding prevention and treatment have been a hot issue of general concern in related research areas. However, the mechanism of action against S. aureus is not well understood. In order to tackle such problem, we used broth microdilution to discuss the antibacterial effect of 5-methyl-2-isopropylphenol and determine inhibitory concentration. In addition, membrane potential and lipid peroxidation levels were also measured under experimental conditions. The experimental results suggested that 300 μg/mL thymol might cause cell membrane damage and decrease of NADPH concentration and increase of NADP+ and lipid peroxidation level. In such condition, thymol has the potential to result in membrane rupture and disruption of cellular homeostasis. Furthermore, we also found that NOX2 is involved in maintaining the balance of NADPH/NADP+ in cells. Finally, our work confirms that NOX2 is a potential downstream target for thymol in the cell. Such target can provide specific guidance and recommendations for its application in antifungal activity. Meanwhile, our study also provides a new inspiration for the molecular mechanism of thymol’s bacteriostatic action.

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Neonatal orbital abscess

Cited by 10 publications

References 13 publications

Neonatal orbital abscess

Neonatal orbital abscess

Клінічний Випадок Ретробульбарного Абсцесу У Новонародженої Дитини

Thymol Disrupts Cell Homeostasis and Inhibits the Growth of Staphylococcus aureus

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