“…1,11,[57][58][59][60] Muscle weakness may affect respiratory health both at birth and throughout life, and respiratory complications may present in either the acute or the chronic setting. 1,11,24,38,[60][61][62][63][64][65][66][67] Respiratory complications are varied, however, and do not necessarily correlate with skeletal muscle function. 1,11,[57][58][59][60] The factors influencing respiratory impairment include respiratory muscle weakness (especially diaphragm weakness), abnormal respiratory control of breathing, swallow and bulbar dysfunction, and failure to thrive resulting in restrictive lung disease, difficulty managing oral and respiratory secretions, and sleep disordered breathing.…”