Neonatal NR3C1 Methylation and Social-Emotional Development at 6 and 18 Months of Age

Folger, Alonzo T.; Ding, Lili; Ji, Hong; Yolton, Kimberly; Ammerman, Robert T.; Ginkel, Judith B. Van; Bowers, Katherine

doi:10.3389/fnbeh.2019.00014

Cited by 21 publications

(12 citation statements)

References 58 publications

(86 reference statements)

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“…The tools have high internal consistency and acceptable sensitivity and specificity. 4 5 ASQ and ASQ-SE were validated for Turkish children earlier. 6 7 8 9…”

Section: Methodsmentioning

confidence: 99%

“…These questionnaires are well-validated, parent-completed screening tools that contain items to assess child capability of communication, gross motor, fine motor, personal-social problems, problem-solving skills, and emotional improvement by age groups. 4,5 There are different questions and tasks that are suitable for each age group from 4 months to 6 years. The questionnaires can be completed by the parents appropriately in a short time.…”

Section: Asq and Asq-sementioning

confidence: 99%

“…The tools have high internal consistency and acceptable sensitivity and specificity. 4,5 ASQ and ASQ-SE were validated for Turkish children earlier. [6][7][8][9] Patient and Sociodemographic Variables Children's data were recorded including birth weight, prematurity, presence of neonatal intensive care unit (NICU) stay, maternal age, percentile of current weight, educational status of parents, and socioeconomic status.…”

Section: Asq and Asq-sementioning

confidence: 99%

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Hypospadias and the Use of the Ages and Stages Questionnaire to Evaluate Neurodevelopmental Status of Boys with Hypospadias

et al. 2021

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Introduction Placental insufficiency is one of the reasons for the reduction of hormone production. Thus, if one of the suspected causes of hypospadias is placental insufficiency, then the neurodevelopmental status of boys with hypospadias may be impaired. The aim of this study was to evaluate the neurodevelopmental status of boys with hypospadias and guide the parents of those who need support to related departments for early intervention. Materials and Methods Boys were divided into two groups, those with hypospadias (group H) and healthy children undergoing traditional circumcision (group C). The parents of the boys completed the Ages and Stages Questionnaire (ASQ) and ASQ–Social Emotional (SE), both of which are screening instruments for the early identification of developmental and social–emotional problems, respectively. Results Seventy-eight boys had hypospadias and 59 were admitted for traditional circumcision. The group H had statistically significant more impaired scores than group C in communication, gross motor, and personal–social skill sections. The multivariate logistic regression analysis revealed that hypospadias was the independent predictive factor for communication and personal–social skills. Conclusion Hypospadias and neurologic impairment may share common etiologic factors. Accordingly, physicians should keep in mind that if a boy presents with hypospadias, the possibility of having neurologic impairment is higher than normal population and early intervention has crucial importance. Every boy with hypospadias should be evaluated for neurodevelopmental status.

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“…The tools have high internal consistency and acceptable sensitivity and specificity. 4 5 ASQ and ASQ-SE were validated for Turkish children earlier. 6 7 8 9…”

Section: Methodsmentioning

confidence: 99%

Section: Asq and Asq-sementioning

confidence: 99%

Section: Asq and Asq-sementioning

confidence: 99%

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Hypospadias and the Use of the Ages and Stages Questionnaire to Evaluate Neurodevelopmental Status of Boys with Hypospadias

et al. 2021

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“…Additionally, they noted an extreme focus on the 1F exon and emphasized the need for widening the examined sequence, in order to include all non-protein-coding first exons of the NR3C1 in the analysis [ 30 ]. Taken together, while several experimental and human studies relate maternal objective hardship as well as maternal distress in pregnancy to methylation changes of NR3C1 , there is some evidence of an association of such methylation changes with offspring psychosocial stress reactivity (e.g., [ 32 , 40 ]) and behavior (e.g., [ 41 ]) and hardly any evidence for the role of methylation changes of NR3C1 in the association between maternal distress in pregnancy and offspring behavior [ 35 ] (for a review, see Cao Lei et al [ 4 ]; Berretta et al [ 37 ]; Sosnowski et al [ 42 ]).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children’s Behavioral Measures

Cao-Lei

Heuvel

Huse

et al. 2021

Cells

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Epigenetic changes are associated with altered behavior and neuropsychiatric disorders and they modify the trajectory of aging. Maternal anxiety during pregnancy is a common environmental challenge for the fetus, causing changes in DNA methylation. Here, we determined the mediating role of DNA methylation and the moderating role of offspring sex on the association between maternal anxiety and children’s behavioral measures. In 83 mother–child dyads, maternal anxiety was assessed in each trimester of pregnancy when the child was four years of age. Children’s behavioral measures and children’s buccal DNA methylation levels (NR3C1, IGF2/H19 ICR, and LINE1) were examined. Higher maternal anxiety during the third trimester was associated with more methylation levels of the NR3C1. Moderating effects of sex on the association between maternal anxiety and methylation were found for IGF2/H19 and LINE1 CpGs. Mediation analysis showed that methylation of NR3C1 could buffer the effects of maternal anxiety on children’s behavioral measures, but this effect did not remain significant after controlling for covariates. In conclusion, our data support an association between maternal anxiety during pregnancy and DNA methylation. The results also underscore the importance of sex differences and timing effects. However, DNA methylation as underlying mechanism of the effect of maternal anxiety during pregnancy on offspring’s behavioral measures was not supported.

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“…To associate maternal and early adversity to infant DNAm, prior studies have employed both epigenome-wide and candidate gene approaches, with a focus on genes involved in the neuroendocrine response and neurodevelopment (2,8,9). Evidence also suggests that differences in DNAm at certain genes is associated with development and behavior (10). However, prior studies have focused primarily on individuallevel, rather than community-level adversity and the association with infant DNAm.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Maternal Community Deprivation and Infant DNA Methylation of the SLC6A4 Gene

DeLano

Folger

Ding

et al. 2020

Front. Public Health

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Introduction: Poverty is negatively associated with health and developmental outcomes. DNA methylation (DNAm) has been proposed as a mechanism that underlies the association between adversity experienced by mothers in poverty and health and developmental outcomes in their offspring. Previous studies have identified associations between individual-level measures of stress and adversity experienced by a mother during pregnancy and infant DNAm. We hypothesized that independent of individual stresses, a mother's community-level deprivation while she is pregnant may also be associated with DNAm among the genes of her offspring that are related to stress response and/or development.Methods: Pregnant mothers (N = 53) completed assessments that measured stress, adversity, and mental health. To evaluate community-level deprivation, mothers' addresses were linked to census-level socioeconomic measures including a composite index of deprivation that combines multiple community-level indicators such as income and highest level of education received. Infant buccal cells were collected at about age 4 weeks to measure DNAm of candidate genes including NR3C1, SCG5, and SLC6A4, which are associated with the stress response and or social and emotional development. Multivariable models were employed to evaluate the association between maternal community deprivation and infant DNAm of candidate genes.Results: No significant associations were identified between maternal community-level deprivation and the methylation of NR3C1 or SCG5, however, maternal community-level deprivation was significantly associated with higher mean methylation across 8 CpG sites in SLC6A4.Conclusion: This study identified an association between community-level measures of deprivation experienced by a mother during pregnancy and DNAm in their offspring. These findings may have implications for understanding how the community context can impact early biology and potential function in the next generation.

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Neonatal NR3C1 Methylation and Social-Emotional Development at 6 and 18 Months of Age

Cited by 21 publications

References 58 publications

Hypospadias and the Use of the Ages and Stages Questionnaire to Evaluate Neurodevelopmental Status of Boys with Hypospadias

Hypospadias and the Use of the Ages and Stages Questionnaire to Evaluate Neurodevelopmental Status of Boys with Hypospadias

Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children’s Behavioral Measures

Associations Between Maternal Community Deprivation and Infant DNA Methylation of the SLC6A4 Gene

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