Neonatal Multisystem Inflammatory Syndrome secondary to SARS‐CoV‐2 infection

Diggikar, Shivashankar; Nanjegowda, Ranjith; Kumar, Ajay; Kumar, Vimal; Kulkarni, Sneha; Venkatagiri, Praveen

doi:10.1111/jpc.15696

Cited by 25 publications

(36 citation statements)

References 10 publications

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“…Demographic, clinical presentation, length of the hospital stay, and outcome of neonates with MIS-N[4,5,14,[16][17][18][19][20][21][22][23][24][25][26][27][28] …”

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confidence: 99%

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Shaiba

Hadid

et al. 2022

Neonatology

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Introduction: Multisystem inflammatory syndrome in neonates (MIS-N) related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increasingly been reported worldwide amid the spread of the SARS-CoV-2 pandemic. Methods: We searched PubMed, EMBASE, and CINAHL and preprint servers (BioRxiv.org and MedRxiv.org) using a specified strategy integrating Medical Subject Headings terms and keywords until October 20, 2021. Our aim was to systematically review demographic profiles, clinical features, laboratory parameters, complications, treatments, and outcomes of neonates with MIS-N. Studies were selected when fulfilling the inclusion criteria. Articles were included if they fulfilled the World Health Organization (WHO), Centers for Disease Control (CDC) definitions of MIS-C, or our proposed definition. Results: Sixteen reports of MIS-N including 47 neonates meeting MIS-N criteria were identified. Presentation included cardiovascular compromise (77%), respiratory involvement (55%), and fever in (36%). Eighty-three percent of patients received steroids, and 76% received immunoglobulin. Respiratory support was provided to 60% of patients and inotropes to 45% of patients. Five (11%) neonates died. Conclusion: The common presentation of MIS-N included cardiorespiratory compromise with the possibility of high mortality. Neonates with MIS-N related to SARS-CoV-2 may be at higher risk of adverse outcomes.

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“…Demographic, clinical presentation, length of the hospital stay, and outcome of neonates with MIS-N[4,5,14,[16][17][18][19][20][21][22][23][24][25][26][27][28] …”

mentioning

confidence: 99%

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Shaiba

Hadid

et al. 2022

Neonatology

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“…Multisystem inflammatory syndrome in neonates (MIS-N) associated with perinatal severe acute respiratory syndrome 2 (SARS-COV-2) exposure is increasingly being reported in recent times [1][2][3]. MIS-N presents with a variety of clinical presentations, requires a high index of suspicion, and is a diagnosis of exclusion.…”

Section: Neonatal Multisystem Inflammatory Syndrome (Mis-n) Presentin...mentioning

confidence: 99%

“…Bezoars have been known to occur in the form of undigested masses found in the stomach but Rapunzel syndrome involves the presence of a gastric trichobezoar with a long tail extending beyond the duodenum and till terminal ileum [1]. Around 100 cases have been described in the literature since then, with a mean age of presentation of 10.8 years [2,3].…”

Section: Rapunzel Syndrome: Diagnosed After Laparotomy In a Young Girlmentioning

confidence: 99%

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Neonatal Multisystem Inflammatory Syndrome (MIS-N) presenting as Necrotizing Enterocolitis and Cardiac Dysfunction

2022

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“…This condition has been reported anecdotally in the newborn population, presenting with fever and multi-site inflammation, especially myocarditis manifesting clinically or with raised biomarkers such as Troponin and ProB-type natriuretic peptide(proBNP) [9]. MIS-C in the paediatric population is now better described; however, the spectrum of possible manifestations in neonates presenting with MIS-N has only been reported in a small number of cases [5,[10][11][12][13][14][15][16]. Authors of this case series (KM and PK) were involved in formally collecting data for the national Indian registry of SARS-CoV2 in newborns, up to August 2020 which was presented at national neonatal conferences and subsequently published [17].…”

Section: Introductionmentioning

confidence: 99%

Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series

Aiyer

Goti³

et al. 2022

Eur J Pediatr

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Multisystem inflammatory syndrome in neonates (MIS-N) is hypothesised to be caused either following transplacental transfer of SARS-CoV2 antibodies or antibodies developed in the neonate after infection with SARS-CoV-2. In this paper, we aim to discuss the clinical manifestations, laboratory features, and management of neonates diagnosed with MIS-N. We collated information from five participating hospitals in western India. A cohort of newborn infants presenting with multi-system involvement, along with the presence of SARS-CoV2 antibodies, was identified. Current proposed international diagnostic criteria for MIS-N were used to group the cases into three categories of Most likely, Possible, and Unlikely MIS-N. A total of 20 cases were reported with a diagnosis of MIS-N, all having high titres of SARS CoV2 IgG antibodies and negative for SARS CoV2 antigens. Most likely MIS ( n = 5) cases presented with respiratory distress (4/5), hypotension and shock (4/5), and encephalopathy (2/5). Inflammatory markers like CRP (1/5), Procalcitonin (1/5), Ferritin (3/5), D-dimer (4/5), and LDH (2/5) were found to be elevated, and four of them had significantly high levels of proBNP. The majority of them (4/5) responded to immunomodulators, three neonates were discharged home, and two died. Possible MIS infants ( n = 9) presented with fever (7/9), respiratory distress (4/9), refusal to feed (6/9), lethargy (5/9), and tachycardia (3/9). ProBNP as a marker of cardiac dysfunction was noted to be elevated in four (4/9) infants, correlating with abnormal echocardiography findings in two. In the Unlikely MIS ( n = 6) category, three (3/6) infants presented with respiratory distress, one (1/6) with shock and cardiac dysfunction, and only one (1/6) with fever. All of them had elevated inflammatory markers. However, there were other potential diagnoses that could have been responsible for the clinical scenarios in these six cases. Conclusion : MIS-N requires a high index of suspicion and should be considered in a neonate presenting with two or more systems involvement, in the presence of SARS-CoV2 antibodies, along with elevated inflammatory markers, once other common neonatal conditions have been ruled out. What is Known: • Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) associated multisystem inflammatory syndrome in children (MIS-C) is widely reported in paediatric population, however only few reports of newborn affection. • MIS-C is known to cause by virus-induced post-infective antibody mediated immune dysregulation with severe multi-system affection. What is New: • MIS-N may present with varied clinical manifestations with multi-system involvement of variable severity with ...

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Neonatal Multisystem Inflammatory Syndrome secondary to SARS‐CoV‐2 infection

Cited by 25 publications

References 10 publications

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Neonatal Multisystem Inflammatory Syndrome (MIS-N) presenting as Necrotizing Enterocolitis and Cardiac Dysfunction

Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series

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