Neonatal Morbidity and 1-Year Survival of Extremely Preterm Infants

Stensvold, Hans Jørgen; Klingenberg, Claus; Støen, Ragnhild; Moster, Dag; Brække, Kristin; Guthe, Hans Jørgen Timm; Astrup, Henriette; Rettedal, Siren; Grønn, Morten; Rønnestad, Arild

doi:10.1542/peds.2016-1821

Cited by 107 publications

(87 citation statements)

References 29 publications

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“…Our survival data compare favorably with the international literature, with higher 1-year survival rates than many European and North American centers. 50,51 Because gestational age in New Zealand is almost invariably confirmed by using early-firsttrimester ultrasound scanning, high survival rates are unlikely to reflect an inappropriate attribution of a more mature gestational age. Among the survivors, although there is clearly a gestational age effect that persists at least until adolescence, the magnitude of the difference diminishes with age.…”

Section: Discussionmentioning

confidence: 99%

Gestational Age, Health, and Educational Outcomes in Adolescents

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Gestational Age, Health, and Educational Outcomes in Adolescents

et al. 2018

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“…Improved neonatal care has resulted in increased survival of extremely preterm infants. However, the rate of severe morbidities remains high and it is inversely related to gestational age (GA) at birth . In the first week of life, extremely preterm infants are subjected to frequent diagnostic blood sampling and in critically ill infants, blood loss due to blood sampling is considered the primary cause of anaemia .…”

Section: Introductionmentioning

confidence: 99%

Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia

et al. 2019

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Aim Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling‐related blood loss and adult blood transfusions administered during postnatal days 1‐14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation. Methods The medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated. Results Blood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1‐14 (median 40.4 mL/kg, interquartile range 23.9‐53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume (rS = 0.870, P < .001). Sampling‐related blood loss on postnatal days 1‐7, adjusted for gestational age at birth and birth weight standard deviation score, was associated with the development of bronchopulmonary dysplasia (BPD) (odds ratio by a 10‐unit increase 2.4, 95% confidence interval 1.1‐5.4) (P = .03). No associations were found between blood sampling and intraventricular haemorrhage or necrotising enterocolitis in the full statistical model. The largest proportion of sampling‐related blood was used for blood gas analyses (48.7%). Conclusion Diagnostic blood sampling led to major endogenous blood loss replaced with adult blood components and was associated with the development of BPD.

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“…Selv ved svangerskapslengde ned mot grensen for biologisk mulighet for overlevelse i uke 22 var overlevelsen for alle fødte 33 % og for barn født i uke 23 var overlevelsen 43 % i perioden 2012 -2015 (Fjalstad et al, 2016), bruken av blodtrykkshevende medikamenter i behandling av intensivkrevende pasienter (Burns et al, 2016), endringer i ernaeringspraksis og bruk av insulin til å behandle høyt blodsukker hos ekstremt premature barn (Stensvold et al, 2015) er beskrevet. Nylig er en publikasjon som beskriver ett års overlevelse og komplikasjoner knyttet til behandling av ekstremt for tidlig fødte barn i Norge akseptert av det amerikanske tidsskriftet Pediatrics (Stensvold et al, 2017).…”

Section: Nyfødtmedisin I Norge Anno 2016unclassified