Neonatal Meningitis

Riley, Harris D.

doi:10.1093/infdis/125.4.420

Cited by 21 publications

(10 citation statements)

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“…The most common diseases caused by ExPEC in humans include neonatal meningitis, UTIs, sepsis, pneumonia, and surgical site infections (Riley, 1972; Russo and Johnson, 2003; Kaper, 2005; Mellata, 2013). NMEC is the leading Gram-negative cause of neonatal meningitis cases (Kim, 2016), while UPEC strains are responsible for 75–90% of uncomplicated UTIs and are the leading cause of catheter-associated UTIs (Foxman, 2014; Becknell et al, 2015).…”

Section: Diseases In Animals and Humans Caused By Expecsmentioning

confidence: 99%

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections

Breland

Eberly

Hadjifrangiskou

2017

Front. Cell. Infect. Microbiol.

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Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds. The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis causing E. coli/meningitis associated E. coli (NMEC/MAEC), and uropathogenic E. coli (UPEC). Many reviews have described current knowledge on ExPEC infection strategies and virulence factors, especially for UPEC. However, surprisingly little has been reported on the regulatory modules that have been identified as critical in ExPEC pathogenesis. Two-component systems (TCSs) comprise the predominant method by which bacteria respond to changing environments and play significant roles in modulating bacterial fitness in diverse niches. Recent studies have highlighted the potential of manipulating signal transduction systems as a means to chemically re-wire bacterial pathogens, thereby reducing selective pressure and avoiding the emergence of antibiotic resistance. This review begins by providing a brief introduction to characterized infection strategies and common virulence factors among APEC, NMEC, and UPEC and continues with a comprehensive overview of two-component signal transduction networks that have been shown to influence ExPEC pathogenesis.

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Section: Diseases In Animals and Humans Caused By Expecsmentioning

confidence: 99%

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections

Breland

Eberly

Hadjifrangiskou

2017

Front. Cell. Infect. Microbiol.

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“…In the first month of life coliform bacteria are the most common cause of purulent meningitis (22). The treatment has been penicillin G or ampicillin in the combination with one of the aminoglucosides.…”

Section: Bacteriological Considerationsmentioning

confidence: 99%

“…The treatment of septicemia and bacterial meningitis of infants often gives discouraging results, especially when due to coliform bacteria in the neonatal period (22,10). In this age-group persistance of bacteria in the cerebrospinal fluid (CSF) for long periods of time during antibiotic therapy is not unusual (151.…”

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confidence: 99%

TREATMENT OF MENINGITIS and SEPTICEMIA IN INFANCY WITH A SULPHAMETHOXAZOLE/TRIMETHOPRIM COMBINATION

Sabel

Brandberg

1975

Acta Paediatrica

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Treatment of meningitis and septicemia in infancy with a sulphamethoxazole/trimethoprim combination. Acta Paediatr Scand, 64:25, 1975.-Ten infants, 8 days to 10 months old, with meningitis and/or septicemia were considered therapeutic failures after conventional antibiotic treatment (i.e. kanamycin, ampicillin and sulfonamides) and given sulphamethoxazole and trimetboprim parenterally. Nine patients recovered, 8 of them rapidly, and one after prolonged treatment for 34 days when kanamycin was added to the combination. One infant improved but later died of complications not related to the treatment. High concentrations in serum and cerebrospinal fluid were achieved with, a daily dose of 30-40 mg sulphamethoxazole and 68 mg trimethoprim per kg without signs of accumulation. No change in resistance of the bacteria isolated was seen.A hemolytic reaction, probably due to the propylene glycol in the solution, was seen in one case. Other possible side-effects in this age-group are discussed. The antibiotic combination used seems to be a good alternative in the therapy of bacterial meningitis of infants caused by gram-negative bacteria. However it should still not be given to icteric or very immature infants and probably not during the first week of life.

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“…The most frequent gram negative bacteria as the causative agent as re ported by some authors are E. coli and Sa' lmonella (Riley, 1972;Sabel and Brandberg, 1975). 5.…”

Section: Introductionmentioning

confidence: 99%

Experience with sulphamethoxazole (SMZ)/trimethoprim (TMP) combination in purulent meningitis not responding to conventional microbial therapy

Sumarmo

Mugiyo

Mandoyono

et al. 1981

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Neonatal Meningitis

Cited by 21 publications

References 0 publications

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections

TREATMENT OF MENINGITIS and SEPTICEMIA IN INFANCY WITH A SULPHAMETHOXAZOLE/TRIMETHOPRIM COMBINATION

Experience with sulphamethoxazole (SMZ)/trimethoprim (TMP) combination in purulent meningitis not responding to conventional microbial therapy

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