Neonatal Meningitis Caused by Ureaplasma Urealyticum

Garland, Suzanne M.; Murton, Laurence J.

doi:10.1097/00006454-198709000-00019

Cited by 50 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although not as common as reports of M. hominis isolations from cerebrospinal fluid (CSF), there have been several case reports and prospective studies published since the1980s proving that Ureaplasma spp. are also causes of meningitis in preterm and full-term neonates (91,115,199,207,256,257,268,305,320,323). In addition to meningitis, both genital mycoplasmas have been detected in a brain abscess in a neonate (228) and ureaplasmas have been isolated directly from brain tissue of preterm twins who died soon after birth (206).…”

Section: Infections Of the Central Nervous Systemmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

View full text Add to dashboard Cite

SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

show abstract

Section: Infections Of the Central Nervous Systemmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

View full text Add to dashboard Cite

show abstract

“…Prospective studies from six different centers (16,91,113,154,159,161) now indicate a significant association between U. urealyticum in the lower respiratory tract and development of chronic lung disease (CLD) in low-birthweight infants. While the occurrence of clinically significant hydrocephalus and meningitis is variable in ureaplasmal CNS infections, it is clear that in some cases it is causal (42,147,149). Available evidence indicates that U. urealyticuminduced CNS and respiratory diseases are uncommon in full-term infants (13,67,68,74,132,147,149).…”

Section: Introductionmentioning

confidence: 99%

Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns

et al. 1993

View full text Add to dashboard Cite

Ureaplasma urealyticum, a common commensal of the urogenital tract of sexually mature humans, is gaining recognition as an important opportunistic pathogen during pregnancy. While its etiologic significance in many aspects of adverse pregnancy remains controversial, recent evidence indicates that U. urealyticum in the absence of other organisms is a cause of chorioamnionitis. Furthermore, ureaplasmal infection of the chorioamnion is significantly associated with premature spontaneous labor and delivery. In at least some cases, it appears to be causal. Present evidence indicates that U. urealyticum is a cause of septicemia, meningitis, and pneumonia in newborn infants, particularly those born prematurely. There is strong but not definitive evidence that ureaplasmal infection of the lower respiratory tract can lead to development of chronic lung disease in very low-birth-weight infants. Although risk factors for colonization of the lower genitourinary tract have been identified, little information is available concerning risk factors for intrauterine infection and host immune responses to invasive infection. Recent establishment of animal models of respiratory and central nervous system diseases should provide an opportunity to evaluate risk factors, pathogenic mechanisms, and operative immune mechanisms. However, the most critical need is additional information concerning indications for diagnosis and treatment as well as efficacy of treatment.

show abstract

“…Reife Neugeborene sind zu 10% [17] bis 45% [18] mit U. urealyticum besiedelt, wobei in diesen Studien der Erreger am häufigsten im Vaginalsekret neugeborener Mädchen gefunden wurde, jedoch auch im Nasopharynxbereich [18]. Nur ein kleiner Teil der Neugeborenen entwickelt eine pulmonale oder septische Infektion [7,13,14,19]. Da in unserer Studie der Erregernachweis aus dem Tubussekret erfolgte, und somit eine Besiedelung der tiefen Atemwege widerspiegelt, sind diese Daten mit den oben zitierten Arbeiten nicht vergleichbar.…”

Section: Diskussionunclassified

“…U. urealyticum kann die unteren Atemwege kleiner Frühge-borener besiedeln und eine Pneumonie verursachen [7] und in weiterer Folge sogar eine mögliche Ursache für eine bronchopulmonale Dysplasie sein [3,[8][9][10][11][12]. Aber auch Krankheitsbilder wie Meningitis oder Sepsis werden durch diesen Erreger hervorgerufen [13][14][15][16]. In seltenen Fällen erkranken auch reife Neugeborene an einer Pneumonie [5,17,18].…”

Section: Introductionunclassified

Ureaplasmapneumonien und Nachweis von <i>Ureaplasma urealyticum</i> im Tubussekret bei Früh- und Neugeborenen

Zotter

Urlesberger

Reiterer

et al. 1999

Gynäkol Geburtshilfliche Rundsch

View full text Add to dashboard Cite

Bei wie vielen Frühgeborenen ≤1250 g und bei wie vielen Neugeborenen >1250 g mit klinischer Symptomatik Ureaplasma urealyticum im Tubussekret nachweisbar war und bei wie vielen eine Pneumonie auftrat. Methodik: Die Patienten wurden in zwei Gruppen unterteilt (Gruppe 1: Geburtsgewicht ≤1250 g, n = 25; Gruppe 2: Geburtsgewicht >1250 g, n = 45) und diese wiederum in zwei Subgruppen (Subgruppe a: U. urealyticum im Tubussekret ohne Pneumonie; Subgruppe b: U. urealyticum im Tubussekret mit Pneumonie). Ergebnisse: Bei 9 Patienten der Gruppe 1 (36%) konnte U. urealyticum nachgewiesen werden, und 5 dieser Patienten (20%) hatten eine Pneumonie (Gruppe 1b). Frühgeborene mit einer Ureaplasmapneumonie hatten im Vergleich zu jenen mit einer blossen Ureaplasmabesiedelung signifikant höhere Beatmungsparameter, eine längere Beatmungsdauer und einen grösseren Sauerstoffbedarf. Bei 6 Patienten der Gruppe 2 (13%) konnte U. urealyticum nachgewiesen werden, und 2 von ihnen (4,4%) hatten eine Pneumonie. Schlussfolgerungen: Bei neonatalen Pneumonien bei sehr kleinen Frühgeborenen, aber auch bei reifen Neugeborenen, sollte stets U. urealyticum in die Differentialdiagnose miteinbezogen werden.

show abstract

Neonatal Meningitis Caused by Ureaplasma Urealyticum

Cited by 50 publications

References 0 publications

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns

Ureaplasmapneumonien und Nachweis von <i>Ureaplasma urealyticum</i> im Tubussekret bei Früh- und Neugeborenen

Contact Info

Product

Resources

About