2014
DOI: 10.4236/ojts.2014.42010
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Neonatal Marfan Syndrome: Improving the Bad Prognosis with a Strict Conservative Treatment with Carvedilol?

Abstract: We report about a successful heart failure therapy with carvedilol in two children with neonatal Marfan syndrome (nMFS). As shown in Case 1, double valve replacement in an infant with neonatal Marfan syndrome is feasible but its benefit on long term is uncertain. Excluding our patient, 3 infants with nMFS from the literature died early after cardiac surgery. Our second case is a unique patient who survives nMFS despite diaphragmatic herniae, dilated neonatal cisterna magna and severe atrioventricular valve ins… Show more

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Cited by 4 publications
(2 citation statements)
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“…In pediatric MFS patients, beta blockers are known to delay cardiac interventions. However, in infant MFS patients, the benefits of using beta blocker are not known 3 23 24) . Infants with MFS who have atrioventricular valve insufficiencies usually require digoxin and/or diuretics to prevent congestive heart failure; this was similar to the requirement in our patients.…”
Section: Discussionmentioning
confidence: 99%
“…In pediatric MFS patients, beta blockers are known to delay cardiac interventions. However, in infant MFS patients, the benefits of using beta blocker are not known 3 23 24) . Infants with MFS who have atrioventricular valve insufficiencies usually require digoxin and/or diuretics to prevent congestive heart failure; this was similar to the requirement in our patients.…”
Section: Discussionmentioning
confidence: 99%
“…We found a total of 20 cases that have been reported in 16 studies (Table ). 3,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Various surgical procedures such as mitral valvuloplasty (31%), MVR (26%), mitral annu- loplasty (11%), tricuspid annuloplasty (9%), tricuspid valvuloplasty (9%), tricuspid valve replacement (6%), valvesparing aortic root replacement (3%), Bentall procedure (3%), and repair of mitral chordae tendineae rupture (3%) were performed in these cases. In these cases, 11 (55%) patients were female, and the average age at surgery was 20 months (range, 1 month to 7 years).…”
Section: Case Reportmentioning
confidence: 99%