Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender-specific manner

Yamamoto, Yasutake; Cushing, Bruce S.; Kramer, Kristin M.; Epperson, Pamela; Hoffman, Gloria E.; Carter, C.S

doi:10.1016/j.neuroscience.2004.02.028

Cited by 141 publications

(141 citation statements)

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“…This programming phenomenon was first described in rats (Swaab and Boer, 1983;Boer, 1993;Boer et al, 1994) and named 'hormonal imprinting' by Csaba (1986). Reviewed in Bales and Perkeybile (2012), single doses of oxytocin given to newborn prairie vole pups have long-term sex-specific consequences on PVN oxytocin and on other systems such as V1aR and estrogen receptor alpha (Yamamoto et al, 2004(Yamamoto et al, , 2006Kramer et al, 2006;Bales et al, 2007a;Pournajafi-Nazarloo et al, 2007). For example, as adults, prairie voles treated with a single dose of oxytocin or an OXTR antagonist given intraperitoneally on postnatal day 1 had altered levels of V1aR in various brain regions in a sex-dependent manner (Bales et al, 2007a), although surprisingly, no treatment effects on OXTR or the dopamine D2 receptor were observed.…”

Section: Oxytocin and Vasopressin Impact Brain Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

153

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Section: Oxytocin and Vasopressin Impact Brain Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

153

146

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“…The dosage of OT was approximately 1 μg/g body weight and for OTA, 0.1 μg/g body weight. The dose of OT and OTA were used because there is extensive literature indicating that during the neonatal period these doses can effect a variety of physiological and behavioral responses in both rats and voles (Uvnäs-Moberg et al, 1998;Sohlström et al, 2002;Kramer et al, 2003;Withuhn et al, 2003;Bales et al, 2004;Cushing et al, 2005;Yamamoto et al, 2004), as well as affect neuronal activation in neonates . A lower dose of OTA was used because the antagonist binds OT receptors (OTR) more effectively than OT, with an affinity for OTR greater than 10 times that of the natural ligand (Barberis and Tribollet, 1996).…”

Section: Methodsmentioning

confidence: 99%

Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles

et al. 2007

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During neonatal development exogenous oxytocin increases ERα immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERα is associated with an increase in ERα mRNA expression and to determine if the effect is specific to ER subtype or if oxytocin also influences ERβ mRNA expression. On the day of birth female prairie vole pups were treated with oxytocin, an oxytocin antagonist, or saline. Brains were collected and RT-PCR was used to determine the effect of treatment on ER mRNA production in the hypothalamus, hippocampus, and cortex. Within 2 hours of treatment oxytocin significantly increased ERα mRNA expression in the hypothalamus and hippocampus, but not the cortex, while inhibiting the effects of endogenous oxytocin reduced the expression of ERα mRNA in the hippocampus. Neonatal treatment did not affect the expression of ERβ mRNA. The results demonstrate that the effects of oxytocin treatment are region and ER subtype specific and that during the neonatal period oxytocin can affect the expression of ERα by altering message production. The regional specific changes in ERα mRNA expression in females are consistent with studies examining the behavioral and physiological effects of neonatal manipulation of oxytocin in females.

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“…The dosage of OT was approximately 1 µg/g body weight and for OTA [d(CH 2 ) 5 , Tyr(Me)², Orn 8 ]-vasotocin, (Peninsula Laboratories, A Division of Bachem, Belmont, CA, USA) was approximately 0.1 µg/g body weight. These doses of OT and OTA were used because there is extensive literature indicating that during the neonatal period these doses can affect a variety of physiological and behavioral responses in both rats and voles [25,5,43], as well as affect neuronal activation in neonates [12]. Hearts were collected from half of the treated animals on D1, 2 hours following treatment, while the other half were collected on postnatal day 21 (D21).…”

Section: Treatmentmentioning

confidence: 99%

“…In addition, a single injection of OT or OTA on the day of birth produced a significant increase in OT immunoreactivity in the brain by postnatal day 21 [43]. Based on previous studies from our laboratory and others showing that neonatal exposure to exogenous OT can have long-term effects on the subsequent expression of adult behavior and physiology [6,7,31,36,41,43], we used postnatal day 1 (D1) and day 21 (D21) female and male rats in the current study. In an attempt to define the possible role of OTR, ANP, NOS and ERs during the early postnatal effects of OT on the heart, animals were treated with OT or OTA on the day of birth and the mRNAs expression for OTR, ANP, iNOS, eNOS, ERα and ERβ in postnatal day 1 (D1) and day 21 (D21) female and male rats were measured utilizing real time reverse transcription-polymerase chain reaction (RT-PCR).…”

Section: Introductionmentioning

confidence: 96%

“…In prairie voles, a single treatment on the day of birth with OT or OTA affected partner preference formation, aggression and reproductive competency in adults [6,31,4]. In addition, a single injection of OT or OTA on the day of birth produced a significant increase in OT immunoreactivity in the brain by postnatal day 21 [43]. Based on previous studies from our laboratory and others showing that neonatal exposure to exogenous OT can have long-term effects on the subsequent expression of adult behavior and physiology [6,7,31,36,41,43], we used postnatal day 1 (D1) and day 21 (D21) female and male rats in the current study.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart

et al. 2007

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Oxytocin (OT) has been implicated in reproductive functions, induction of maternal behavior as well as endocrine and neuroendocrine regulation of the cardiovascular system. Here we demonstrate that neonatal manipulation of OT can modulate the mRNAs expression for OT receptor (OTR), atrial natriuretic peptide (ANP), endothelial nitric oxide synthase (eNOS) and estrogen receptor alpha (ERα) in the heart. On the first day of postnatal life, female and male rats were randomly assigned to receive one of following treatments; (a) 50 µl i.p. injection of 7 µg OT, (b) 0.7 µg of OT antagonist (OTA), or (c) isotonic saline (SAL). Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERα and estrogen receptor beta (ERβ) were compared by age, treatment, and sex utilizing Real Time PCR. OT treatment significantly increased heart OTR, ANP and eNOS mRNAs expression on D1 in both males and females, ERα increased only in females. While there were significant changes in the relative expression of all types of mRNA between D1 and D21 there were no significant treatment effects observed in D21 animals. OTA treatment significantly decreased basal ANP and eNOS mRNAs expression on D1 in both sexes. The results indicate that during the early postnatal period OT can have an immediate effect on the expression OTR, ANP, eNOS, and ERα mRNAs and that these effects are mitigated by D21. Also with the exception of ERα mRNA, the effects are the same in both sexes.

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Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender-specific manner

Cited by 141 publications

References 44 publications

Developmental Perspectives on Oxytocin and Vasopressin

Developmental Perspectives on Oxytocin and Vasopressin

Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles

Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart

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